Searching for up to 100 curated homologs for GFF25 FitnessBrowser__WCS417:GFF25 (530 a.a.)
Found high-coverage hits (≥70%) to 72 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
7v74A Thermostabilized human prestin in complex with sulfate
31% identity, 95% coverage of query (215 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
30% identity, 95% coverage of query (211 bits)
Build an alignment for GFF25 and 2 homologs with ≥ 30% identity
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7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
27% identity, 93% coverage of query (192 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 93% coverage of query (192 bits)
TC 2.A.53.1.12 / Q0P7I2 Symbiotic sulfate transporter-1, SST1 of 645 aas from Lotus japonicus
28% identity, 94% coverage of query (191 bits)
SUT11_ARATH / Q9SAY1 Sulfate transporter 1.1; AST101; High-affinity sulfate transporter 1; Hst1At from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.7 / Q9SAY1 High affinity sulfate transporter, Sultr1.1 regulated differently from Sultr1.2 (2.A.53.1.6) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
27% identity, 95% coverage of query (190 bits)
bst3.1 / CAE46442.1 sulphate transporter from Brassica napus (see paper)
26% identity, 94% coverage of query (184 bits)
SHST2 / CAA57711.1 high affinity sulphate transporter from Stylosanthes hamata (see paper)
26% identity, 94% coverage of query (184 bits)
SUT21_ARATH / O04722 Sulfate transporter 2.1; AST68 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
31% identity, 73% coverage of query (184 bits)
ST1 / CAA65291.1 high affinity sulphate transporter from Hordeum vulgare (see paper)
27% identity, 97% coverage of query (182 bits)
SUT33_ARATH / Q9SXS2 Probable sulfate transporter 3.3; AST91 from Arabidopsis thaliana (Mouse-ear cress)
26% identity, 96% coverage of query (181 bits)
S2611_CAVPO / G3C7W6 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Cavia porcellus (Guinea pig) (see paper)
TC 2.A.53.1.9 / G3C7W6 Slc26a11 Cl-/oxalate or sulfate (but not bicarbonate) exchanger from Cavia porcellus (see paper)
30% identity, 97% coverage of query (180 bits)
TC 2.A.53.1.3 / P53391 The molybdate (high affinity)/Sulfate (lower affinity) transporter, ShsT1 from Stylosanthes hamata (see paper)
SHST1 / CAA57710.1 high affinity sulphate transporter from Stylosanthes hamata (see paper)
26% identity, 94% coverage of query (179 bits)
SUT22_ARATH / P92946 Sulfate transporter 2.2; AST56; AtH14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
31% identity, 72% coverage of query (179 bits)
SUT13_ARATH / Q9FEP7 Sulfate transporter 1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 96% coverage of query (179 bits)
SULT2_CHLRE / A8J6J0 Proton/sulfate cotransporter 2 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 2 papers)
TC 2.A.53.1.8 / A8J6J0 The proton:sulfate symporter, SulP from Chlamydomonas reinhardtii (see paper)
26% identity, 95% coverage of query (176 bits)
S2611_MOUSE / Q80ZD3 Sodium-independent sulfate anion transporter; Kidney brain anion transporter; KBAT; Solute carrier family 26 member 11 from Mus musculus (Mouse) (see 5 papers)
28% identity, 98% coverage of query (169 bits)
SUT12_ARATH / Q9MAX3 Sulfate transporter 1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.6 / Q9MAX3 The sulfate transporter, Sultr1.2 with C-terminal STAS domain that is required both for activity and biogenesis/stability (Shibagaki and Grossman, 2006). It physically interacts with 0-acetylserine (thiol)lyase (cysteine synthetase) via its STAS domain. This interaction stimulates the activity of from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
SULTR1;2 / RF|NP_849899.1 sulfate transporter 1.2 from Arabidopsis thaliana (see paper)
27% identity, 96% coverage of query (169 bits)
DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
32% identity, 89% coverage of query (167 bits)
TC 2.A.53.1.4 / P53393 Low-affinity sulfate:H+ symporter, Sut3 from Stylosanthes hamata (see paper)
27% identity, 96% coverage of query (166 bits)
S26A5_DANRE / Q7T2C4 Prestin; Solute carrier family 26 member 5 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
26% identity, 85% coverage of query (155 bits)
TC 2.A.53.2.8 / Q8K142 The mouse Slc26a6 anion exchanger (same substrate specificity as its human orthologue (2.A.53.2.7)), but Cl- and HSO4- are transported rapidly. Moreover, although Cl-/HCO3- and Cl-/OH- exchange reactions are electroneutral, Cl-:oxalate exchange is electrogenic (Chernova et al., 2005). Also catalyzes Cl-:formate exchange (see paper)
Slc26a6 / RF|NP_599252.2 solute carrier family 26, member 6 from Mus musculus
29% identity, 78% coverage of query (154 bits)
S26A6_MOUSE / Q8CIW6 Solute carrier family 26 member 6; Anion exchange transporter; Chloride-formate exchanger; Pendrin-L1; Pendrin-like protein 1; Putative anion transporter-1; Pat-1 from Mus musculus (Mouse) (see 22 papers)
29% identity, 78% coverage of query (154 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
30% identity, 78% coverage of query (153 bits)
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
29% identity, 93% coverage of query (151 bits)
S2611_HUMAN / Q86WA9 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Homo sapiens (Human) (see 3 papers)
28% identity, 98% coverage of query (150 bits)
TC 2.A.53.2.12 / G3C7W4 Slc26a6 Cl-/oxalate, sulfate or bicarbonate exchanger from Cavia porcellus (see paper)
29% identity, 92% coverage of query (149 bits)
S26A6_HUMAN / Q9BXS9 Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 from Homo sapiens (Human) (see 7 papers)
TC 2.A.53.2.7 / Q9BXS9 The human Slc26a6 anion exchanger (transports sulfate, formate, oxalate, chloride and bicarbonate in antiport with any one of these anions) (Jiang et al., 2002). However, Cl- and HSO4- are transported slowly; Cl-/HCO3-, Cl-/OH- and Cl-:oxalate exchange reactions are electroneutral (Chernova et al., 2005). (The oxalate nephrolithiasis gene; Clark et al., 2008). Catalyzes 1Cl-/2HCO3- antiport from Homo sapiens (Human) (see 4 papers)
28% identity, 85% coverage of query (149 bits)
S26A5_CHICK / A0FKN5 Prestin; Solute carrier family 26 member 5 from Gallus gallus (Chicken) (see 5 papers)
TC 2.A.53.2.9 / A0FKN5 The electrogenic divalent anion: chloride exchanger (1:1 stoichiometry) (transports sulfate, chloride, and oxalate) from Gallus gallus (Chicken) (see paper)
27% identity, 80% coverage of query (145 bits)
S26A5_MOUSE / Q99NH7 Prestin; Solute carrier family 26 member 5 from Mus musculus (Mouse) (see 5 papers)
24% identity, 98% coverage of query (142 bits)
S26A5_MERUN / Q9JKQ2 Prestin; Solute carrier family 26 member 5 from Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) (see 4 papers)
25% identity, 95% coverage of query (142 bits)
TC 2.A.53.2.5 / Q99NH7 Prestin, the outer hair cell voltage-sensitive motor protein (voltage sensitivity depends on intracellular Cl- and HCO3- which may bind to prestin). Prestin transports anions including formate and oxalate; transport and voltage-sensing capabilities are independent functions of the same protein (Bai et al., 2009). Prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility from Mus musculus (Mouse) (see paper)
Slc26a5 / GB|AAG59999.2 prestin from Mus musculus
24% identity, 98% coverage of query (141 bits)
S26A5_RAT / Q9EPH0 Prestin; Solute carrier family 26 member 5 from Rattus norvegicus (Rat) (see 11 papers)
24% identity, 98% coverage of query (140 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
24% identity, 98% coverage of query (140 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
28% identity, 75% coverage of query (140 bits)
Q9URY8 Probable sulfate permease C869.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
27% identity, 79% coverage of query (140 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
24% identity, 98% coverage of query (138 bits)
S26A5_HUMAN / P58743 Prestin; Solute carrier family 26 member 5 from Homo sapiens (Human) (see 2 papers)
TC 2.A.53.2.19 / P58743 Prestin (Solute carrier family 26 member 5) from Homo sapiens (see 3 papers)
24% identity, 98% coverage of query (138 bits)
8sgwC / A0A8D0Z6H8 Pendrin in complex with chloride
24% identity, 95% coverage of query (136 bits)
8sieC Pendrin in complex with bicarbonate
24% identity, 95% coverage of query (136 bits)
8shcC Pendrin in complex with niflumic acid
24% identity, 95% coverage of query (136 bits)
7xulA Human slc26a3 in complex with tenidap
28% identity, 79% coverage of query (134 bits)
7xujA Human slc26a3 in complex with uk5099
28% identity, 79% coverage of query (133 bits)
7xuhA / P40879 Down-regulated in adenoma in complex with tqr1122
27% identity, 79% coverage of query (132 bits)
S26A3_HUMAN / P40879 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Homo sapiens (Human) (see 16 papers)
TC 2.A.53.2.18 / P40879 Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) from Homo sapiens (see 12 papers)
27% identity, 79% coverage of query (130 bits)
TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
25% identity, 94% coverage of query (128 bits)
TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
26% identity, 92% coverage of query (127 bits)
S26A2_RAT / O70531 Sulfate transporter; Diastrophic dysplasia protein homolog; Solute carrier family 26 member 2 from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 79% coverage of query (127 bits)
sutA / AAF14540.1 SutA from Penicillium chrysogenum (see paper)
27% identity, 79% coverage of query (125 bits)
S26A2_MOUSE / Q62273 Sulfate transporter; Diastrophic dysplasia protein homolog; ST-OB; Solute carrier family 26 member 2 from Mus musculus (Mouse) (see 4 papers)
27% identity, 78% coverage of query (125 bits)
S26A4_RAT / Q9R154 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Rattus norvegicus (Rat) (see 4 papers)
25% identity, 74% coverage of query (125 bits)
S26A4_MOUSE / Q9R155 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.53.2.4 / Q9R155 Pendrin (Pendred) syndrome (hereditary deafness) anion transporter (Na+-independent). Anions transported: iodide (thyroid gland; apical membrane of follicular epithelium); bicarbonate (kidney; apical membrane of intercalated cells of the cortical collecting duct), chloride, formate, etc. Pendrin probably catalyzes uniport and anion/anion antiport (SLC26A4). It also regulates Na+ absorption by the epithelial Na+ channel (Wall and Pech, 2008). CFTR controls the rate of liquid secretion while pendrin mediates transcellular HCO3- from Mus musculus (Mouse) (see paper)
24% identity, 74% coverage of query (124 bits)
sB sulfate permease from Emericella nidulans (see 3 papers)
26% identity, 79% coverage of query (124 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
25% identity, 92% coverage of query (122 bits)
S26A4_HUMAN / O43511 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Homo sapiens (Human) (see 34 papers)
TC 2.A.53.2.17 / O43511 Pendrin (Sodium-independent chloride/iodide/bicarbonate transporter) (Solute carrier family 26 member 4, Slc26a4) from Homo sapiens (see 30 papers)
26% identity, 74% coverage of query (120 bits)
BICA_SYNP2 / Q14SY0 Bicarbonate transporter BicA from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
26% identity, 77% coverage of query (120 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
25% identity, 96% coverage of query (119 bits)
S26A2_BOVIN / Q9BEG8 Sulfate transporter; Solute carrier family 26 member 2 from Bos taurus (Bovine) (see paper)
26% identity, 79% coverage of query (118 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
24% identity, 95% coverage of query (118 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
27% identity, 77% coverage of query (117 bits)
S26A2_HUMAN / P50443 Sulfate transporter; Diastrophic dysplasia protein; Solute carrier family 26 member 2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.53.2.1 / P50443 Sulfate/anion transporter (diastrophic dysplasia protein) (SLC26A2). It catalyzes electroneutral SO4-, OH- from Homo sapiens (Human) (see 12 papers)
26% identity, 78% coverage of query (115 bits)
TC 2.A.53.1.2 / P23622 Sulfate permease II from Neurospora crassa (see 4 papers)
24% identity, 76% coverage of query (115 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
25% identity, 78% coverage of query (105 bits)
6ki1B / Q55415 The transmembrane domain of a cyanobacterium bicarbonate transporter bica (see paper)
27% identity, 72% coverage of query (105 bits)
S26A1_HUMAN / Q9H2B4 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.53.2.16 / Q9H2B4 Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger. Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003). The mouse and rat orthologues have the same specificities and functions. Loss in mice is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013). When homozygous, they can cause severe nephrocalcinosis from Homo sapiens (see 5 papers)
27% identity, 85% coverage of query (104 bits)
S26A7_MOUSE / Q8R2Z3 Anion exchange transporter; Solute carrier family 26 member 7 from Mus musculus (Mouse) (see 9 papers)
22% identity, 88% coverage of query (101 bits)
S26A7_HUMAN / Q8TE54 Anion exchange transporter; Solute carrier family 26 member 7 from Homo sapiens (Human) (see 11 papers)
TC 2.A.53.2.6 / Q8TE54 Basolateral kidney cortical collecting duct and parietal cell chloride/sulfate/oxalate permease or channel, SLC26A7 [substrate preference: NO3- >> Cl- = Br- = I- > SO42- = Glucarate-] (minimal OH- and HCO3- transport; regulated by cytoplasmic pH) (see 7 papers)
SLC26A7 / RF|NP_439897.1 anion exchange transporter from Homo sapiens (see paper)
22% identity, 88% coverage of query (94.4 bits)
TC 2.A.53.3.8 / Q8F8H7 SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter from Leptospira interrogans (see paper)
22% identity, 97% coverage of query (94.0 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
27% identity, 79% coverage of query (91.3 bits)
SULH3_SCHPO / O59782 Probable sulfate permease C320.05 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
23% identity, 78% coverage of query (88.6 bits)
TC 2.A.53.3.5 / F5R8F2 SulP homologue with fused C-terminal STAS/CAP-ED domains (function unknown COG0659) from Methyloversatilis universalis FAM5
27% identity, 88% coverage of query (81.6 bits)
S26A8_HUMAN / Q96RN1 Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8 from Homo sapiens (Human) (see 8 papers)
20% identity, 79% coverage of query (58.2 bits)
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Lawrence Berkeley National Laboratory