Sites on a Tree

 

Searching for up to 100 curated homologs for GFF2519 FitnessBrowser__psRCH2:GFF2519 (278 a.a.)

Found high-coverage hits (≥70%) to 21 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4lsbB / B4EFV2 Crystal structure of a putative lyase/mutase from burkholderia cenocepacia j2315
    48% identity, 97% coverage of query (188 bits)

2ze3A Crystal structure of dfa0005 complexed with alpha-ketoglutarate: a novel member of the icl/pepm superfamily from alkali-tolerant deinococcus ficus (see paper)
    38% identity, 83% coverage of query (141 bits)

Y1998_MYCTO / P9WLN8 Uncharacterized protein MT2054 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
Y1998_MYCTU / P9WLN9 Uncharacterized protein Rv1998c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    32% identity, 79% coverage of query (90.9 bits)

Build an alignment

Build an alignment for GFF2519 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

4iqdA / A0A6L7HJ56 Crystal structure of carboxyvinyl-carboxyphosphonate phosphorylmutase from bacillus anthracis
    26% identity, 92% coverage of query (62.8 bits)

Q2L886 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see paper)
    27% identity, 85% coverage of query (58.9 bits)

Q7Z986 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see 2 papers)
    25% identity, 84% coverage of query (58.2 bits)

Q2L8W6 Methylisocitrate lyase (EC 4.1.3.30) from Toxoplasma gondii (see paper)
    29% identity, 73% coverage of query (57.8 bits)

OAHA / Q6PNM8 oxaloacetate acetylhydrolase monomer (EC 3.7.1.1) from Botryotinia fuckeliana (see 4 papers)
Q6PNM8 oxaloacetase (EC 3.7.1.1) from Botrytis cinerea (see 2 papers)
    26% identity, 74% coverage of query (54.3 bits)

bcpA / P11435 carboxyphosphonoenolpyruvate phosphonomutase monomer (EC 2.7.8.23) from Streptomyces hygroscopicus (see 3 papers)
    27% identity, 87% coverage of query (53.9 bits)

ACEA_HALVD / D4GTL3 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    26% identity, 82% coverage of query (53.1 bits)

3m0kA Structure of oxaloacetate acetylhydrolase in complex with the product oxalate
    27% identity, 84% coverage of query (52.4 bits)

3fa3B / Q2L887 Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, trigonal crystal form (see paper)
    27% identity, 72% coverage of query (51.6 bits)

A2QP68 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see paper)
Q2L887 2,3-Dimethylmalate lyase (EC 4.1.3.32) from Aspergillus niger (see paper)
    27% identity, 72% coverage of query (51.6 bits)

3fa3J Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, trigonal crystal form
    27% identity, 72% coverage of query (51.6 bits)

A7ESB3 oxaloacetase (EC 3.7.1.1) from Sclerotinia sclerotiorum (see paper)
    26% identity, 74% coverage of query (50.8 bits)

3fa4A Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, triclinic crystal form
    28% identity, 72% coverage of query (50.8 bits)

3m0jA Structure of oxaloacetate acetylhydrolase in complex with the inhibitor 3,3-difluorooxalacetate (see paper)
    27% identity, 84% coverage of query (48.9 bits)

Q8T8D9 phosphoenolpyruvate mutase (EC 5.4.2.9) from Trypanosoma cruzi (see paper)
    26% identity, 80% coverage of query (48.5 bits)

D5LIR7 oxaloacetase (EC 3.7.1.1) from Cryphonectria parasitica (see paper)
    27% identity, 84% coverage of query (48.1 bits)

OADC_PSEAE / Q9HUU1 Oxaloacetate decarboxylase; EC 4.1.1.112 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    29% identity, 84% coverage of query (45.1 bits)

3b8iA / Q9HUU1 Crystal structure of oxaloacetate decarboxylase from pseudomonas aeruginosa (pa4872) in complex with oxalate and mg2+. (see paper)
    29% identity, 81% coverage of query (45.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory