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Searching for up to 100 curated homologs for GFF2590 FitnessBrowser__WCS417:GFF2590 (455 a.a.)

Found high-coverage hits (≥70%) to 11 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pchA / Q51508 isochorismate synthase (EC 5.4.4.2) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
PCHA_PSEAE / Q51508 Salicylate biosynthesis isochorismate synthase; Isochorismate mutase; EC 5.4.4.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    43% identity, 98% coverage of query (338 bits)

menF / P23973 isochorismate synthase monomer (EC 5.4.4.2) from Bacillus subtilis (strain 168) (see paper)
    35% identity, 98% coverage of query (261 bits)

FepF / b0593 isochorismate synthase EntC (EC 5.4.4.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
entC / P0AEJ2 isochorismate synthase EntC (EC 5.4.4.2) from Escherichia coli (strain K12) (see 10 papers)
ENTC_ECOLI / P0AEJ2 Isochorismate synthase EntC; Isochorismate mutase; EC 5.4.4.2 from Escherichia coli (strain K12) (see 9 papers)
P0AEJ2 isochorismate synthase (EC 5.4.4.2) from Escherichia coli (see paper)
entC / MB|P0AEJ2 isochorismate mutase from Escherichia coli K12 (see 4 papers)
    33% identity, 79% coverage of query (186 bits)

3hwoA / P0AEJ2 Crystal structure of escherichia coli enterobactin-specific isochorismate synthase entc in complex with isochorismate (see paper)
    33% identity, 79% coverage of query (186 bits)

5jy8A An iron-bound structure of the isochorismate synthase entc
    34% identity, 79% coverage of query (186 bits)

5jxzA A low magnesium structure of the isochorismate synthase, entc
    34% identity, 79% coverage of query (185 bits)

Build an alignment

Build an alignment for GFF2590 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ICS_CATRO / Q9ZPC0 Isochorismate synthase, chloroplastic; EC 5.4.4.2 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see 3 papers)
    29% identity, 87% coverage of query (152 bits)

ICS1_ARATH / Q9S7H8 Isochorismate synthase 1, chloroplastic; AtIcs1; IcsI; Enhanced disease susceptibility 16; Eds16; Isochorismate mutase 1; Salicylic acid induction deficient 2; Sid2; menF-like protein 1; EC 5.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9S7H8 isochorismate synthase (EC 5.4.4.2) from Arabidopsis thaliana (see 6 papers)
    29% identity, 78% coverage of query (145 bits)

ICS2_ARATH / Q9M9V6 Isochorismate synthase 2, chloroplastic; AtIcs2; Isochorismate mutase 2; menF-like protein 2; EC 5.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9M9V6 isochorismate synthase (EC 5.4.4.2) from Arabidopsis thaliana (see 2 papers)
    30% identity, 78% coverage of query (143 bits)

TRPE_SALTY / P00898 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
    27% identity, 72% coverage of query (86.7 bits)

1i1qA / P00898 Structure of the cooperative allosteric anthranilate synthase from salmonella typhimurium (see paper)
    27% identity, 72% coverage of query (86.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory