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Searching for up to 100 curated homologs for GFF2610 HP15_2554 D-3-phosphoglycerate dehydrogenase-like protein (409 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A4VGK3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas stutzeri (see paper)
    75% identity, 100% coverage of query (642 bits)

Q9I6H5 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas aeruginosa (see paper)
    74% identity, 100% coverage of query (637 bits)

SerA / b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655 (see 36 papers)
serA / P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12) (see 36 papers)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12) (see paper)
C3SVM7 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see paper)
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see 7 papers)
serA / RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12 (see 5 papers)
    64% identity, 100% coverage of query (538 bits)

1ybaA The active form of phosphoglycerate dehydrogenase
    64% identity, 99% coverage of query (536 bits)

2p9eA / P0A9T0 Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase (see paper)
    64% identity, 99% coverage of query (533 bits)

1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
    64% identity, 99% coverage of query (533 bits)

1sc6D / P0A9T0 Crystal structure of w139g d-3-phosphoglycerate dehydrogenase complexed with NAD+ (see paper)
    61% identity, 99% coverage of query (481 bits)

Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    53% identity, 99% coverage of query (452 bits)

P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    50% identity, 98% coverage of query (400 bits)

SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    50% identity, 98% coverage of query (398 bits)

U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Acanthamoeba castellanii (see paper)
    50% identity, 99% coverage of query (393 bits)

SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    49% identity, 98% coverage of query (392 bits)

SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
    39% identity, 79% coverage of query (203 bits)

hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    36% identity, 78% coverage of query (199 bits)

A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha (see paper)
    35% identity, 78% coverage of query (186 bits)

1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
    39% identity, 74% coverage of query (182 bits)

7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
    36% identity, 73% coverage of query (180 bits)

A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
    36% identity, 80% coverage of query (180 bits)

6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
    36% identity, 73% coverage of query (180 bits)

7ewhA Crystal structure of human phgdh in complex with homoharringtonine
    36% identity, 73% coverage of query (180 bits)

6rihA Crystal structure of phgdh in complex with compound 9
    36% identity, 73% coverage of query (180 bits)

6plgA Crystal structure of human phgdh complexed with compound 15
    36% identity, 73% coverage of query (180 bits)

6rj3A Crystal structure of phgdh in complex with compound 15
    36% identity, 73% coverage of query (180 bits)

6rj5A Crystal structure of phgdh in complex with compound 39
    36% identity, 73% coverage of query (180 bits)

6plfA Crystal structure of human phgdh complexed with compound 1
    36% identity, 73% coverage of query (180 bits)

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor (see paper)
    36% identity, 75% coverage of query (179 bits)

PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
    36% identity, 73% coverage of query (179 bits)

A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
    35% identity, 79% coverage of query (179 bits)

Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
    35% identity, 73% coverage of query (177 bits)

SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
    35% identity, 81% coverage of query (177 bits)

SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
    35% identity, 73% coverage of query (177 bits)

serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
    35% identity, 78% coverage of query (176 bits)

SERA3_ARATH / Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
    36% identity, 79% coverage of query (174 bits)

Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
    32% identity, 78% coverage of query (163 bits)

5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
    32% identity, 78% coverage of query (163 bits)

H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
    31% identity, 75% coverage of query (151 bits)

2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
    34% identity, 74% coverage of query (150 bits)

HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
    34% identity, 71% coverage of query (150 bits)

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
    34% identity, 74% coverage of query (150 bits)

6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
    31% identity, 78% coverage of query (147 bits)

F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
    31% identity, 78% coverage of query (146 bits)

Q608T2 hydroxypyruvate reductase (EC 1.1.1.81) from Methylococcus capsulatus (see paper)
    30% identity, 75% coverage of query (136 bits)

Build an alignment

Build an alignment for GFF2610 and 42 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PGDH1 / A2DLU8 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
    29% identity, 86% coverage of query (135 bits)

6ih6A / G4XDR8 Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
    29% identity, 78% coverage of query (106 bits)

4njmA / Q76KF5 Crystal structure of phosphoglycerate bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica (see paper)
    28% identity, 74% coverage of query (104 bits)

4njoA Crystal structure of cofactor(NAD+) bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica
    28% identity, 74% coverage of query (104 bits)

DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
    28% identity, 78% coverage of query (102 bits)

1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
    29% identity, 72% coverage of query (101 bits)

CTBP_ARATH / O23702 C-terminal binding protein AN; CtBP; Protein ANGUSTIFOLIA; Protein DETORQUEO from Arabidopsis thaliana (Mouse-ear cress) (see 13 papers)
    25% identity, 73% coverage of query (62.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory