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Searching for up to 100 curated homologs for GFF282 FitnessBrowser__psRCH2:GFF282 (274 a.a.)

Found high-coverage hits (≥70%) to 59 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

P5CR_PSEAE / P22008 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    76% identity, 100% coverage of query (397 bits)

3triA / Q83A21 Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
    43% identity, 99% coverage of query (221 bits)

PROC1 / F2E7Q2 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Hordeum vulgare subsp. vulgare (see paper)
    42% identity, 97% coverage of query (188 bits)

Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Shewanella loihica PV-4
    39% identity, 99% coverage of query (188 bits)

2ag8A / Q9K1N1 NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
    37% identity, 97% coverage of query (176 bits)

5bseA / G7KRM5 Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
    38% identity, 97% coverage of query (171 bits)

5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline
    38% identity, 97% coverage of query (171 bits)

5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+
    38% identity, 97% coverage of query (171 bits)

5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+
    38% identity, 97% coverage of query (171 bits)

G7KRM5 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Medicago truncatula (see paper)
    38% identity, 97% coverage of query (170 bits)

P5CR1_MOUSE / Q922W5 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Mus musculus (Mouse) (see paper)
    37% identity, 96% coverage of query (169 bits)

P5CR2_BACSU / P54552 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; PCA reductase 2; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
    34% identity, 98% coverage of query (168 bits)

8tcwA / P32322 Structure of pycr1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl) benzoic acid (see paper)
    37% identity, 97% coverage of query (166 bits)

PYCR1 / P32322 pyrroline-5-carboxylate reductase 1 subunit (EC 1.5.1.2) from Homo sapiens (see 2 papers)
P5CR1_HUMAN / P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
P32322 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 7 papers)
    37% identity, 96% coverage of query (166 bits)

8td1A Structure of pycr1 complexed with 3-(6-oxa-9-azaspiro(4.5)decane-9- carbonyl)benzoic acid
    37% identity, 97% coverage of query (166 bits)

8td0A Structure of pycr1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2, 1-b][1,3]thiazole-3-carboxylic acid
    37% identity, 97% coverage of query (166 bits)

8tczA Structure of pycr1 complexed with 2-(pyridin-2-yl)cyclopropane-1- carboxylic acid
    37% identity, 97% coverage of query (166 bits)

8tcxA Structure of pycr1 complexed with 2,4-dioxo-1,2,3,4- tetrahydroquinazoline-6-carboxylic acid
    37% identity, 97% coverage of query (166 bits)

6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid
    37% identity, 97% coverage of query (166 bits)

8tcyA Structure of pycr1 complexed with 7-fluoro-2-oxo-1,2,3,4- tetrahydroquinoline-6-carboxylic acid
    37% identity, 97% coverage of query (165 bits)

5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid
    37% identity, 97% coverage of query (165 bits)

5uatC Structure of human pycr-1 complexed with NADPH
    37% identity, 97% coverage of query (165 bits)

2izzA Crystal structure of human pyrroline-5-carboxylate reductase
    37% identity, 97% coverage of query (165 bits)

8tcuA Structure of pycr1 complexed with 2-chloro-5-(2-oxoimidazolidin-1-yl) benzoic acid
    37% identity, 97% coverage of query (165 bits)

2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP
    37% identity, 96% coverage of query (165 bits)

2gr9A Crystal structure of p5cr complexed with nadh
    37% identity, 96% coverage of query (165 bits)

5uauA Structure of human pycr-1 complexed with proline
    37% identity, 96% coverage of query (165 bits)

8tcvB Structure of pycr1 complexed with 4-bromobenzene-1,3-dicarboxylic acid
    37% identity, 97% coverage of query (165 bits)

6xp0A Structure of human pycr1 complexed with n-formyl l-proline
    37% identity, 97% coverage of query (164 bits)

O87725 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Acetoanaerobium sticklandii (see paper)
    34% identity, 97% coverage of query (160 bits)

proC / AAG27705.1 delta 1-pyrroline-5-carboxylate reductase from Bradyrhizobium japonicum (see paper)
    39% identity, 98% coverage of query (158 bits)

P5CR2_HUMAN / Q96C36 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
Q96C36 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 2 papers)
    36% identity, 96% coverage of query (156 bits)

P5CR_METAC / Q9HH99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
    37% identity, 97% coverage of query (155 bits)

6xp1A Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate
    36% identity, 96% coverage of query (152 bits)

6xp2A Structure of human pycr1 complexed with l-thiazolidine-4-carboxylate
    36% identity, 96% coverage of query (152 bits)

ProC / b0386 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
proC / P0A9L8 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli (strain K12) (see 8 papers)
P5CR_ECOLI / P0A9L8 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Escherichia coli (strain K12) (see 2 papers)
proC / MB|P0A9L8 pyrroline-5-carboxylate reductase from Escherichia coli K12 (see paper)
    36% identity, 97% coverage of query (151 bits)

P5CR1_BACSU / P0CI77 Pyrroline-5-carboxylate reductase 1; P5C reductase 1; P5CR 1; PCA reductase 1; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
    33% identity, 98% coverage of query (149 bits)

Q4DH60 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Trypanosoma cruzi (see paper)
    34% identity, 98% coverage of query (144 bits)

CCNA_00528 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Caulobacter crescentus NA1000
    39% identity, 96% coverage of query (136 bits)

Build an alignment

Build an alignment for GFF282 and 39 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

2rcyA / Q8IDC6 Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
    29% identity, 97% coverage of query (134 bits)

DVU2332 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Desulfovibrio vulgaris Hildenborough JW710
    35% identity, 95% coverage of query (132 bits)

Q5NQR9 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Zymomonas mobilis subsp. mobilis (see paper)
    33% identity, 97% coverage of query (130 bits)

F4K884 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Arabidopsis thaliana (see paper)
    38% identity, 76% coverage of query (124 bits)

P5CR3_HUMAN / Q53H96 Pyrroline-5-carboxylate reductase 3; P5C reductase 3; P5CR 3; Pyrroline-5-carboxylate reductase-like protein; EC 1.5.1.2 from Homo sapiens (Human) (see paper)
    31% identity, 97% coverage of query (124 bits)

BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Bacteroides thetaiotaomicron VPI-5482
    34% identity, 94% coverage of query (119 bits)

APS3 / D2IKN6 1-piperideine 6-carboxylate reductase from Fusarium incarnatum (see paper)
    36% identity, 71% coverage of query (117 bits)

DvMF_3161 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Desulfovibrio vulgaris Miyazaki F
    33% identity, 95% coverage of query (113 bits)

2ahrE / Q9A1S9 Crystal structures of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
    30% identity, 96% coverage of query (113 bits)

APF3 / S0DLN5 L-piperideine 6-carboxylate reductase from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (see 3 papers)
APF3_GIBF5 / S0DLN5 Delta-1-pyrroline-5-carboxylate reductase apf3; Apicidin F synthesis protein 3; EC 1.5.1.- from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi) (see 2 papers)
    30% identity, 97% coverage of query (112 bits)

2amfA Crystal structure of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes
    30% identity, 96% coverage of query (112 bits)

P5CR_KLULA / Q6CR99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    31% identity, 78% coverage of query (110 bits)

PRO3 / P32263 pyrroline-5-carboxylate reductase subunit (EC 1.5.1.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
P5CR_YEAST / P32263 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    29% identity, 98% coverage of query (109 bits)

Q97ZT3 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Saccharolobus solfataricus (see paper)
    26% identity, 98% coverage of query (99.0 bits)

CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Pedobacter sp. GW460-11-11-14-LB5
    29% identity, 98% coverage of query (86.3 bits)

P5CR_TREPA / P27771 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Treponema pallidum (strain Nichols) (see paper)
    28% identity, 95% coverage of query (75.9 bits)

UCSG_ACRSP / A0A411KUQ8 Pyrroline-5-carboxylate reductase ucsG; UCS1025A pyrrolizidinone biosynthesis cluster protein G; EC 1.5.1.- from Acremonium sp. (see paper)
    28% identity, 77% coverage of query (68.2 bits)

TR08_CURCL / A0A348AXY1 Pyrroline-5-carboxylate reductase-like protein TR08; KK-1 biosynthesis cluster protein TR08; EC 1.5.1.- from Curvularia clavata (see paper)
    25% identity, 88% coverage of query (67.0 bits)

PHQD_PENFE / L0E163 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; Paraherquamide biosynthesis cluster protein D; EC 1.5.1.2 from Penicillium fellutanum (see 2 papers)
    27% identity, 73% coverage of query (58.9 bits)

P5CR3_BACSU / Q00777 Pyrroline-5-carboxylate reductase 3; P5C reductase 3; P5CR 3; PCA reductase 3; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
    23% identity, 99% coverage of query (57.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory