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Searching for up to 100 curated homologs for GFF2889 FitnessBrowser__WCS417:GFF2889 (467 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf1N1B4_5129 D-galacturonate transporter ExuT from Pseudomonas fluorescens FW300-N1B4
    89% identity, 100% coverage of query (814 bits)

CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
    54% identity, 96% coverage of query (482 bits)

BT4105 D-galacturonate transporter ExuT from Bacteroides thetaiotaomicron VPI-5482
    49% identity, 96% coverage of query (441 bits)

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    32% identity, 85% coverage of query (187 bits)

Build an alignment

Build an alignment for GFF2889 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
    28% identity, 95% coverage of query (171 bits)

TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
    28% identity, 95% coverage of query (171 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    25% identity, 91% coverage of query (146 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    26% identity, 89% coverage of query (141 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    25% identity, 87% coverage of query (141 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    26% identity, 89% coverage of query (141 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    24% identity, 88% coverage of query (118 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    26% identity, 70% coverage of query (112 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    26% identity, 73% coverage of query (107 bits)

ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
    23% identity, 96% coverage of query (99.0 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    23% identity, 87% coverage of query (97.4 bits)

ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    22% identity, 92% coverage of query (83.2 bits)

S17A9_RAT / P0DX21 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Rattus norvegicus (Rat) (see 2 papers)
    21% identity, 95% coverage of query (70.5 bits)

BWI76_RS23725 2-deoxy-D-ribonate transporter 2 from Klebsiella michiganensis M5al
    21% identity, 88% coverage of query (68.9 bits)

S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
    22% identity, 84% coverage of query (64.3 bits)

S17A9_MOUSE / Q8VCL5 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Mus musculus (Mouse) (see 5 papers)
    20% identity, 95% coverage of query (63.5 bits)

TC 2.A.1.53.2 / Q5ZUB4 The valine uptake permease, PhtJ (required for maximal growth in macrophages and Acanthamoeba castellanii) (see paper)
    21% identity, 82% coverage of query (53.1 bits)

genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    23% identity, 82% coverage of query (52.0 bits)

Q9SA71 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Arabidopsis thaliana (see paper)
    24% identity, 76% coverage of query (51.2 bits)

A0A0H3JLD7 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Staphylococcus aureus (see paper)
    23% identity, 98% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory