Searching for up to 100 curated homologs for GFF2942 HP15_2886 protein of unknown function cysteine-rich region domain protein (259 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HP15_4088 L-lactate dehydrogenase, LutA subunit from Marinobacter adhaerens HP15
    55% identity, 95% coverage of query (293 bits)

RR42_RS21295 L-lactate dehydrogenase, LutA subunit from Cupriavidus basilensis FW507-4G11
    52% identity, 98% coverage of query (277 bits)

Q5F885 L-lactate dehydrogenase (subunit 3/3) (EC 1.1.1.27) from Neisseria gonorrhoeae (see paper)
    52% identity, 95% coverage of query (271 bits)

lutA / O07020 iron-sulfur oxidase subunit used in L-lactate utilization (EC 1.1.1.27) from Bacillus subtilis (strain 168) (see 2 papers)
LUTA_BACSU / O07020 Lactate utilization protein A from Bacillus subtilis (strain 168) (see paper)
    45% identity, 92% coverage of query (197 bits)

LUTA_BACCR / Q81GA5 Lactate utilization protein A from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see paper)
    42% identity, 92% coverage of query (186 bits)

BPHYT_RS26975 L-lactate dehydrogenase, LldE subunit from Burkholderia phytofirmans PsJN
    41% identity, 90% coverage of query (156 bits)

YkgE / b0306 putative lactate utilization oxidoreductase YkgE from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    37% identity, 92% coverage of query (141 bits)

lldE / Q8EGS4 L-lactate dehydrogenase LldE subunit (EC 1.1.2.3) from Shewanella oneidensis (strain MR-1) (see paper)
    34% identity, 90% coverage of query (137 bits)

Build an alignment

Build an alignment for GFF2942 and 8 homologs with ≥ 30% identity

Or download the sequences

Additional hits (identity < 30%)

DVU_3033 / Q726S3 quinone-dependent L-lactate dehydrogenase large subunit (EC 1.1.2.3) from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) (see 4 papers)
    29% identity, 92% coverage of query (111 bits)

DVU_3028 / Q726S8 quinone-dependent D-lactate dehydrogenase iron-sulfur subunit (EC 1.1.2.5) from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) (see 3 papers)
    25% identity, 89% coverage of query (88.6 bits)

SMc00926 D-lactate dehydrogenase, iron-sulfur subunit GlcF (EC 1.1.99.6) from Sinorhizobium meliloti 1021
    27% identity, 87% coverage of query (80.9 bits)

PGA1_c29700 D-lactate dehydrogenase, iron-sulfur subunit GlcF (EC 1.1.99.6) from Phaeobacter inhibens BS107
    28% identity, 83% coverage of query (77.0 bits)

Psest_3839 D-lactate/glycolate dehydrogenase, iron-sulfur subunit GlcF (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
    25% identity, 87% coverage of query (70.5 bits)

TFRB_METTM / D9PUX5 Fumarate reductase (CoM/CoB) subunit B; Thiol:fumarate reductase subunit B; EC 1.3.4.1 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see 2 papers)
    26% identity, 85% coverage of query (68.6 bits)

YghL / b4467 glycolate dehydrogenase, putative iron-sulfur subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
glcF / P52074 glycolate dehydrogenase, putative iron-sulfur subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 4 papers)
GLCF_ECOLI / P52074 Glycolate oxidase iron-sulfur subunit; Glycolate dehydrogenase subunit GlcF; Glycolate oxidase subunit GlcF; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcF / RF|YP_026190.1 glycolate oxidase, iron-sulfur subunit from Escherichia coli K12 (see paper)
glcF / AAB02532.1 glycolate oxidase subunit, (Fe-S)protein from Escherichia coli (see paper)
    24% identity, 88% coverage of query (67.0 bits)

RR42_RS17315 D-lactate dehydrogenase, iron-sulfur subunit GlcF (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
    22% identity, 83% coverage of query (62.8 bits)

GlpC / b2243 anaerobic glycerol-3-phosphate dehydrogenase subunit C (EC 1.1.5.3) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
glpC / P0A996 anaerobic glycerol-3-phosphate dehydrogenase subunit C (EC 1.1.5.3) from Escherichia coli (strain K12) (see 4 papers)
    24% identity, 80% coverage of query (58.9 bits)

GYD1 / A8J2E9 glycolate dehydrogenase (EC 1.1.99.14) from Chlamydomonas reinhardtii (see 4 papers)
    27% identity, 73% coverage of query (54.3 bits)

hdrD / P96797 CoB-CoM heterodisulfide reductase catalytic subunit D (EC 1.8.98.1) from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 2 papers)
HDRD_METBF / P96797 Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit D; CoB--CoM heterodisulfide reductase iron-sulfur subunit D; Coenzyme B:coenzyme M:methanophenazine oxidoreductase subunit D; EC 1.8.98.1 from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 2 papers)
TC 3.D.7.1.1 / P96797 HDRD, component of H2:heterodisulfide oxidoreductase, HHO. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf from Methanosarcina barkeri (see 3 papers)
hdrD / GB|AAZ70545.1 CoB--CoM heterodisulfide reductase iron-sulfur subunit D; EC 1.8.98.1 from Methanosarcina barkeri str. Fusaro (see 3 papers)
    23% identity, 83% coverage of query (49.7 bits)

BPHYT_RS03150 Phosphoglycerate dehydrogenase (EC:1.1.1.95) from Burkholderia phytofirmans PsJN
    23% identity, 77% coverage of query (47.0 bits)

Or start over