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Searching for up to 100 curated homologs for GFF30 FitnessBrowser__Phaeo:GFF30 (326 a.a.)

Found high-coverage hits (≥70%) to 59 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    35% identity, 94% coverage of query (168 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    35% identity, 94% coverage of query (168 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    35% identity, 94% coverage of query (168 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    35% identity, 94% coverage of query (156 bits)

AGMAT / Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
GDAH_HUMAN / Q9BSE5 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Homo sapiens (Human) (see 3 papers)
Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
    32% identity, 94% coverage of query (148 bits)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    31% identity, 93% coverage of query (139 bits)

gbh / Q8KZT5 guanidinobutyrase subunit (EC 3.5.3.7) from Arthrobacter sp. (strain KUJ 8602) (see paper)
Q8KZT5 D-arginase (EC 3.5.3.10); guanidinobutyrase (EC 3.5.3.7) from Arthrobacter sp. (see paper)
    30% identity, 94% coverage of query (138 bits)

gbuA / Q88EE2 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    30% identity, 94% coverage of query (134 bits)

GDAH_MOUSE / A2AS89 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Mus musculus (Mouse) (see paper)
    30% identity, 94% coverage of query (134 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    32% identity, 88% coverage of query (127 bits)

Build an alignment

Build an alignment for GFF30 and 10 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    29% identity, 94% coverage of query (126 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    29% identity, 94% coverage of query (126 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    28% identity, 94% coverage of query (119 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    31% identity, 90% coverage of query (117 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    31% identity, 90% coverage of query (117 bits)

7loxA The structure of agmatinase from e. Coli at 3.2 a displaying guanidine in the active site
    33% identity, 82% coverage of query (117 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    32% identity, 82% coverage of query (116 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    30% identity, 96% coverage of query (113 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    30% identity, 95% coverage of query (111 bits)

ARG2 / Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    31% identity, 73% coverage of query (106 bits)

4dz4B / Q2T3W4 X-ray crystal structure of a hypothetical agmatinase from burkholderia thailandensis (see paper)
    29% identity, 83% coverage of query (105 bits)

W8R465 guanidinobutyrase (EC 3.5.3.7) from Aspergillus niger (see paper)
    27% identity, 92% coverage of query (103 bits)

ARGI1_ORYSI / B8AU84 Arginase 1, mitochondrial; Arginine amidohydrolase 1; EC 3.5.3.1 from Oryza sativa subsp. indica (Rice) (see paper)
    31% identity, 73% coverage of query (103 bits)

6vsuE / P46637 Arginase from arabidopsis thaliana in complex with ornithine (see paper)
    31% identity, 73% coverage of query (101 bits)

arginase / P46637 arginase (EC 3.5.3.1) from Arabidopsis thaliana (see paper)
ARGI1_ARATH / P46637 Arginase 1, mitochondrial; Agmatinase ARGAH1; Arginine amidohydrolase 1; AtARGAH1; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    31% identity, 73% coverage of query (101 bits)

ARG1 / Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    31% identity, 73% coverage of query (100 bits)

Q1K7T0 agmatinase (EC 3.5.3.11) from Neurospora crassa (see paper)
    25% identity, 94% coverage of query (99.4 bits)

CH_124010 agmatinase from Magnaporthe grisea 70-15 (see 3 papers)
    25% identity, 94% coverage of query (98.6 bits)

KlGBU1 / Q6CIB4 guanidinobutyrase (EC 3.5.3.7) from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (see paper)
GBU1_KLULA / Q6CIB4 Guanidinobutyrase; EC 3.5.3.7 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    27% identity, 87% coverage of query (95.5 bits)

ARGI2_ARATH / Q9ZPF5 Arginase 2, chloroplastic/mitochondrial; Agmatinase ARGAH2; Arginine amidohydrolase 2; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 73% coverage of query (95.1 bits)

ARGI_MEDTR / G7JFU5 Arginase, mitochondrial; Agmatinase ARGAH; Arginine amidohydrolase; MtARGAH; EC 3.5.3.1; EC 3.5.3.11 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    32% identity, 73% coverage of query (91.3 bits)

6vstD / G7JFU5 Arginase from medicago truncatula in complex with ornithine (see paper)
    32% identity, 73% coverage of query (90.9 bits)

6vstA Arginase from medicago truncatula in complex with ornithine
    32% identity, 73% coverage of query (90.9 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    27% identity, 81% coverage of query (87.8 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    26% identity, 96% coverage of query (85.5 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    26% identity, 96% coverage of query (85.5 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    29% identity, 70% coverage of query (70.9 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    27% identity, 92% coverage of query (70.5 bits)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    25% identity, 89% coverage of query (65.5 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    25% identity, 89% coverage of query (65.1 bits)

3lhlA / Q18A84 Crystal structure of a putative agmatinase from clostridium difficile
    24% identity, 80% coverage of query (65.1 bits)

SPEB_METJA / Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q57757 agmatinase (EC 3.5.3.11) from Methanocaldococcus jannaschii (see paper)
    28% identity, 73% coverage of query (64.3 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    25% identity, 85% coverage of query (62.4 bits)

O08701 arginase (EC 3.5.3.1) from Rattus norvegicus (see paper)
    24% identity, 76% coverage of query (62.4 bits)

N515DRAFT_0348 Arginase (EC 3.5.3.1) from Dyella japonica UNC79MFTsu3.2
    25% identity, 84% coverage of query (57.0 bits)

1hqgA Crystal structure of the h141c arginase variant complexed with products ornithine and urea
    23% identity, 87% coverage of query (55.8 bits)

1t5gA Arginase-f2-l-arginine complex
    23% identity, 87% coverage of query (55.1 bits)

1t5fA Arginase i-aoh complex
    23% identity, 87% coverage of query (55.1 bits)

1hq5A Crystal structure of the binuclear manganese metalloenzyme arginase complexed with s-(2-boronoethyl)-l-cysteine, an l-arginine analogue
    23% identity, 87% coverage of query (55.1 bits)

1d3vA Crystal structure of the binuclear manganese metalloenzyme arginase complexed with 2(s)-amino-6-boronohexanoic acid, an l-arginine analog
    23% identity, 87% coverage of query (55.1 bits)

ARGI1_RAT / P07824 Arginase-1; Liver-type arginase; Type I arginase; EC 3.5.3.1 from Rattus norvegicus (Rat) (see 6 papers)
P07824 arginase (EC 3.5.3.1) from Rattus norvegicus (see 5 papers)
    23% identity, 87% coverage of query (55.1 bits)

1t4tA Arginase-dinor-noha complex
    23% identity, 87% coverage of query (55.1 bits)

1t4sA Arginase-l-valine complex
    23% identity, 87% coverage of query (55.1 bits)

1t4rA Arginase-descarboxy-nor-noha complex
    23% identity, 87% coverage of query (55.1 bits)

1t4pA Arginase-dehydro-abh complex
    23% identity, 87% coverage of query (55.1 bits)

1r1oA Amino acid sulfonamides as transition-state analogue inhibitors of arginase
    23% identity, 87% coverage of query (55.1 bits)

1hqhA Crystal structure of the binuclear manganese metalloenzyme arginase complexed with nor-n-hydroxy-l-arginine
    23% identity, 87% coverage of query (55.1 bits)

1hqfA / P07824 Crystal structure of the binuclear manganese metalloenzyme arginase complexed with n-hydroxy-l-arginine (see paper)
    23% identity, 87% coverage of query (55.1 bits)

A0A0D5ZYA4 arginase (EC 3.5.3.1) from Heteropneustes fossilis (see paper)
    24% identity, 88% coverage of query (50.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory