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Searching for up to 100 curated homologs for GFF3050 FitnessBrowser__psRCH2:GFF3050 (414 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGA1_c12670 D-lactate transporter, substrate binding component from Phaeobacter inhibens BS107
    34% identity, 89% coverage of query (194 bits)

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Build an alignment for GFF3050 and 1 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

3i09A / A0A0H2WF95 Crystal structure of a periplasmic binding protein (bma2936) from burkholderia mallei at 1.80 a resolution
    24% identity, 92% coverage of query (100 bits)

BRAC_PSEAE / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein; LIVAT-BP; Leu/Ile/Val/Thr/Ala-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
TC 3.A.1.4.8 / P21175 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    26% identity, 83% coverage of query (97.1 bits)

3i45A / Q2RWX8 Crystal structure of putative twin-arginine translocation pathway signal protein from rhodospirillum rubrum atcc 11170
    25% identity, 80% coverage of query (84.3 bits)

AZOBR_RS08260 L-proline and D-alanine ABC transporter, substrate-binding component from Azospirillum brasilense Sp245
    25% identity, 79% coverage of query (81.6 bits)

Pf6N2E2_2921 ABC transporter for L-leucine/L-phenylalanine/D-alanine, substrate-binding component LivK from Pseudomonas fluorescens FW300-N2E2
    23% identity, 80% coverage of query (75.1 bits)

AABP_PSEAE / Q9HUQ0 Amino acid binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    28% identity, 71% coverage of query (74.3 bits)

4gnrA / J9PBT7 1.0 angstrom resolution crystal structure of the branched-chain amino acid transporter substrate binding protein livj from streptococcus pneumoniae str. Canada mdr_19a in complex with isoleucine
    25% identity, 82% coverage of query (72.8 bits)

TC 3.A.1.4.10 / Q8DQI1 ABC transporter substrate-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    25% identity, 82% coverage of query (72.4 bits)

TC 3.A.1.4.5 / Q8NRW1 UrtB, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    24% identity, 78% coverage of query (68.2 bits)

HSERO_RS00870 L-proline ABC transporter, substrate-binding component from Herbaspirillum seropedicae SmR1
    24% identity, 86% coverage of query (63.5 bits)

3ip5A / Q7CX36 Structure of atu2422-gaba receptor in complex with alanine (see paper)
    24% identity, 79% coverage of query (63.5 bits)

3ip9A Structure of atu2422-gaba receptor in complex with gaba
    24% identity, 79% coverage of query (63.5 bits)

3ip7A Structure of atu2422-gaba receptor in complex with valine
    24% identity, 79% coverage of query (63.5 bits)

3ip6A Structure of atu2422-gaba receptor in complex with proline
    24% identity, 79% coverage of query (63.5 bits)

3ipcA Structure of atu2422-gaba f77a mutant receptor in complex with leucine
    24% identity, 79% coverage of query (63.2 bits)

8hicA / Q7V3V9 Crystal structure of urta from prochlorococcus marinus str. Mit 9313 in complex with urea and calcium
    22% identity, 76% coverage of query (55.8 bits)

TC 3.A.1.4.3 / Q9L3M3 BraC, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
braC / CAB75553.1 periplasmic binding protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    22% identity, 81% coverage of query (54.7 bits)

fmdD / CAA75186.1 amide-urea binding protein from Methylophilus methylotrophus (see paper)
    23% identity, 77% coverage of query (53.5 bits)

4q6wA / Q7VS30 Crystal structure of periplasmic binding protein type 1 from bordetella pertussis tohama i complexed with 3-hydroxy benzoic acid
    21% identity, 89% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory