Searching for up to 100 curated homologs for GFF3145 FitnessBrowser__psRCH2:GFF3145 (234 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
48% identity, 98% coverage of query (201 bits)
Build an alignment for GFF3145 and 1 homologs with ≥ 30% identity
Or download the sequences
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
29% identity, 98% coverage of query (90.5 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
25% identity, 99% coverage of query (80.5 bits)
8bcjB / Q9HZ96 Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
30% identity, 97% coverage of query (80.1 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
27% identity, 97% coverage of query (75.9 bits)
1p33B / P42556 Pteridine reductase from leishmania tarentolae complex with NADPH and mtx (see paper)
29% identity, 98% coverage of query (74.3 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
27% identity, 97% coverage of query (73.2 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
28% identity, 97% coverage of query (72.8 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
28% identity, 97% coverage of query (72.8 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
28% identity, 97% coverage of query (72.8 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
28% identity, 97% coverage of query (72.8 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
28% identity, 97% coverage of query (72.8 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.8 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
27% identity, 97% coverage of query (72.8 bits)
2yhuA Trypanosoma brucei ptr1 in complex with inhibitor whf30
27% identity, 97% coverage of query (72.8 bits)
2x9gA High resolution structure of tbptr1 in complex with pemetrexed
27% identity, 97% coverage of query (72.8 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
27% identity, 100% coverage of query (72.4 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
27% identity, 100% coverage of query (72.4 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.4 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
27% identity, 97% coverage of query (72.0 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
27% identity, 97% coverage of query (72.0 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
27% identity, 97% coverage of query (72.0 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (72.0 bits)
1mxhA / Q8I814 Crystal structure of substrate complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi (see paper)
33% identity, 96% coverage of query (71.6 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
28% identity, 97% coverage of query (70.9 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (70.1 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (70.1 bits)
2c7vC / O76290 Structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate (see paper)
27% identity, 97% coverage of query (69.7 bits)
YqfD / b2902 putative oxidoreductase YgfF from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ygfF / RF|NP_417378 uncharacterized oxidoreductase ygfF from Escherichia coli K12 (see paper)
28% identity, 96% coverage of query (69.7 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
27% identity, 97% coverage of query (69.7 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
27% identity, 97% coverage of query (69.7 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
27% identity, 97% coverage of query (69.7 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
27% identity, 97% coverage of query (69.7 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
27% identity, 97% coverage of query (69.7 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (69.7 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (69.7 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
27% identity, 97% coverage of query (69.7 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
27% identity, 97% coverage of query (69.7 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
27% identity, 97% coverage of query (69.7 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
27% identity, 97% coverage of query (69.7 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
27% identity, 97% coverage of query (69.7 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
27% identity, 97% coverage of query (69.7 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
27% identity, 97% coverage of query (69.7 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
27% identity, 97% coverage of query (69.7 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
27% identity, 97% coverage of query (69.7 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
27% identity, 97% coverage of query (69.7 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
27% identity, 97% coverage of query (69.7 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
27% identity, 97% coverage of query (69.7 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
27% identity, 97% coverage of query (69.7 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
27% identity, 97% coverage of query (69.7 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
27% identity, 97% coverage of query (69.7 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
27% identity, 97% coverage of query (69.7 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
27% identity, 97% coverage of query (69.3 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
27% identity, 97% coverage of query (69.3 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
27% identity, 97% coverage of query (69.3 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
27% identity, 97% coverage of query (69.3 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (69.3 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (69.3 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 97% coverage of query (69.3 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
27% identity, 97% coverage of query (69.3 bits)
3gn1C Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00067116)
28% identity, 97% coverage of query (68.9 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
27% identity, 97% coverage of query (68.9 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
26% identity, 97% coverage of query (68.9 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
26% identity, 97% coverage of query (68.9 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
26% identity, 97% coverage of query (68.9 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
26% identity, 97% coverage of query (68.9 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
26% identity, 97% coverage of query (68.9 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
26% identity, 97% coverage of query (68.9 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
26% identity, 97% coverage of query (68.9 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
26% identity, 97% coverage of query (68.9 bits)
FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
28% identity, 97% coverage of query (68.6 bits)
FABG_RICPR / P50941 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Rickettsia prowazekii (strain Madrid E)
P50941 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Rickettsia prowazekii (see paper)
29% identity, 97% coverage of query (68.6 bits)
1vl8B / Q9WYS2 Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
27% identity, 96% coverage of query (68.6 bits)
uxaD / Q9WYS2 fructuronate reductase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
27% identity, 96% coverage of query (68.6 bits)
FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
29% identity, 97% coverage of query (68.6 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
27% identity, 97% coverage of query (68.6 bits)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
29% identity, 97% coverage of query (68.2 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
26% identity, 97% coverage of query (68.2 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
26% identity, 97% coverage of query (68.2 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
26% identity, 97% coverage of query (68.2 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
26% identity, 97% coverage of query (68.2 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
26% identity, 97% coverage of query (68.2 bits)
1mxfA Crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi
32% identity, 96% coverage of query (68.2 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
27% identity, 100% coverage of query (67.8 bits)
3jq7C Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
29% identity, 97% coverage of query (67.4 bits)
8jfgA / G2M827 Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori (see paper)
25% identity, 97% coverage of query (66.6 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
24% identity, 97% coverage of query (66.6 bits)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
29% identity, 97% coverage of query (66.6 bits)
4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
24% identity, 97% coverage of query (66.6 bits)
5k6aC Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
27% identity, 97% coverage of query (66.6 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
27% identity, 97% coverage of query (66.2 bits)
pldh-t / Q988B7 pyridoxal 4-dehydrogenase subunit (EC 1.1.1.107) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (see 2 papers)
PLDH_RHILO / Q988B7 Pyridoxal 4-dehydrogenase; tPLDH; EC 1.1.1.107 from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) (see paper)
Q988B7 pyridoxal 4-dehydrogenase (EC 1.1.1.107) from Mesorhizobium loti (see paper)
26% identity, 97% coverage of query (65.9 bits)
Or start over
Lawrence Berkeley National Laboratory