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Searching for up to 100 curated homologs for GFF3215 FitnessBrowser__Phaeo:GFF3215 (205 a.a.)

Found high-coverage hits (≥70%) to 82 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4gf0A / A3STM0 Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
    63% identity, 100% coverage of query (245 bits)

Q59721 4-chlorobenzoate dehalogenase (EC 3.8.1.6) from Burkholderia sp. (see paper)
bphK / CAA54033.1 glutathione S-transferase from Paraburkholderia xenovorans LB400 (see paper)
    32% identity, 100% coverage of query (110 bits)

2gdrA / Q59721 Crystal structure of a bacterial glutathione transferase (see paper)
    32% identity, 100% coverage of query (110 bits)

2dsaA Ternary complex of bphk, a bacterial gst
    32% identity, 99% coverage of query (109 bits)

3uarA / Q60CN1 Crystal structure of glutathione transferase (target efi-501774) from methylococcus capsulatus str. Bath with gsh bound
    33% identity, 100% coverage of query (106 bits)

1pmtA / P15214 Glutathione transferase from proteus mirabilis (see paper)
    31% identity, 100% coverage of query (99.4 bits)

GST_PROMI / P15214 Glutathione S-transferase GST-6.0; GST B1-1; EC 2.5.1.18 from Proteus mirabilis (see paper)
    31% identity, 100% coverage of query (99.4 bits)

4g9hA / Q8D0L3 Crystal structure of glutahtione s-transferase homolog from yersinia pestis, target efi-501894, with bound glutathione
    30% identity, 98% coverage of query (97.8 bits)

1f2eA / O33705 Structure of sphingomonad, glutathione s-transferase complexed with glutathione
GST / AAC46031.1 glutathione S-transferase from Sphingomonas paucimobilis (see paper)
    32% identity, 99% coverage of query (97.4 bits)

6m1tA / O30347 Bacterial beta class sphingomonas chungbukensis glutathione s- transferase
    32% identity, 100% coverage of query (93.2 bits)

Build an alignment

Build an alignment for GFF3215 and 10 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

XYLK / AAC44159.1 glutathione S-transferase from Cycloclasticus oligotrophus (see paper)
    28% identity, 99% coverage of query (87.8 bits)

4kgiC Crystal structure of a glutathione transferase family member from shigella flexneri, target efi-507258, bound gsh, tev-his-tag linker in active site
    28% identity, 99% coverage of query (79.0 bits)

Gst / b1635 glutathione S-transferase GstA (EC 2.5.1.18) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gstA / P0A9D2 glutathione S-transferase GstA (EC 2.5.1.18) from Escherichia coli (strain K12) (see 8 papers)
GSTA_ECOLI / P0A9D2 Glutathione S-transferase GstA; GST B1-1; EC 2.5.1.18 from Escherichia coli (strain K12) (see 6 papers)
GST / BAA07509.1 glutathione transferase from Escherichia coli (see paper)
    28% identity, 99% coverage of query (79.0 bits)

1a0fA Crystal structure of glutathione s-transferase from escherichia coli complexed with glutathionesulfonic acid
    28% identity, 99% coverage of query (79.0 bits)

GST_BRUAN / P81065 Glutathione S-transferase; EC 2.5.1.18 from Brucella anthropi (Ochrobactrum anthropi) (see paper)
P81065 glutathione transferase (EC 2.5.1.18) from Brucella anthropi (see paper)
2ntoA / P81065 Structure of the glutathione transferase from ochrobactrum anthropi in complex with glutathione (see paper)
    29% identity, 99% coverage of query (73.2 bits)

desD / Q2G4C2 4-carboxy-2-hydroxyhexa-2,4-dienedioate cis-trans isomerase from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) (see paper)
    32% identity, 81% coverage of query (73.2 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    25% identity, 91% coverage of query (67.4 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    32% identity, 91% coverage of query (67.4 bits)

4mf6A / B1FXZ2 Crystal structure of glutathione transferase bgramdraft_1843 from burkholderia graminis, target efi-507289, with two glutathione molecules bound per one protein subunit
    27% identity, 95% coverage of query (67.4 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    24% identity, 95% coverage of query (67.0 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    29% identity, 87% coverage of query (64.7 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    29% identity, 87% coverage of query (64.3 bits)

Q8DMB4 glutathione transferase (EC 2.5.1.18) from Thermosynechococcus vestitus (see paper)
    28% identity, 96% coverage of query (63.5 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    30% identity, 91% coverage of query (63.5 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    30% identity, 87% coverage of query (62.8 bits)

3ublA / Q8F2Y8 Crystal structure of glutathione transferase (target efi-501770) from leptospira interrogans with gsh bound
    27% identity, 78% coverage of query (61.6 bits)

3qawA / B9VX79 Crystal structure of a glutathione-s-transferase from antarctic clam laternula elliptica in a complex with glutathione (see paper)
    23% identity, 89% coverage of query (61.6 bits)

7rkaA / A0A1P8PEY0 Crystal structure analysis of colorado potato beetle glutathione-s transferase ldgstu1 (see paper)
    26% identity, 85% coverage of query (60.8 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    30% identity, 91% coverage of query (60.5 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    26% identity, 96% coverage of query (59.3 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    26% identity, 96% coverage of query (59.3 bits)

8ai8A / Q55139 Crystal structure of glutathione transferase chi 1 from synechocystis sp. Pcc 6803 in complex with glutathione (see paper)
    26% identity, 97% coverage of query (59.3 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    26% identity, 96% coverage of query (59.3 bits)

7pkaA Synechocystis sp. Pcc6803 glutathione transferase chi 1, gsoh bound
    26% identity, 97% coverage of query (59.3 bits)

4l8eA / D3VKV1 Crystal structure of a glutathione transferase family member from xenorhabdus nematophila, target efi-507418, with two gsh per subunit
    24% identity, 96% coverage of query (58.9 bits)

5hfkA / P77526 Crystal structure of a glutathione s-transferase protein from escherichia coli och 157:h7 str. Sakai (ecs3186, target efi-507414) with bound glutathione
    28% identity, 99% coverage of query (58.9 bits)

2x64B / Q9PE18 Glutathione-s-transferase from xylella fastidiosa
    27% identity, 100% coverage of query (58.9 bits)

isoJ / CAB55824.1 glutathione S-transferase from Rhodococcus sp. AD45 (see paper)
    28% identity, 91% coverage of query (58.5 bits)

3gx0A Crystal structure of gsh-dependent disulfide bond oxidoreductase
    28% identity, 99% coverage of query (57.4 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    26% identity, 90% coverage of query (57.0 bits)

4pnfB / Q7JZM3 Glutathione s-transferase from drosophila melanogaster - isozyme e6 (see paper)
    24% identity, 93% coverage of query (57.0 bits)

GEDE_ASPTN / Q0CCY0 Glutathione S-transferase-like protein gedE; Geodin synthesis protein E; EC 2.5.1.- from Aspergillus terreus (strain NIH 2624 / FGSC A1156) (see 7 papers)
    28% identity, 93% coverage of query (57.0 bits)

YfcG / b2302 disulfide reductase from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yfcG / P77526 disulfide bond oxidoreductase YfcG from Escherichia coli (strain K12) (see 4 papers)
YFCG_ECOLI / P77526 Disulfide-bond oxidoreductase YfcG; GSH-dependent disulfide-bond oxidoreductase YfcG; GST N1-1; GST-like protein YfcG; Organic hydroperoxidase; EC 1.8.4.-; EC 1.11.1.- from Escherichia coli (strain K12) (see 2 papers)
    28% identity, 99% coverage of query (57.0 bits)

Q87E36 glutathione transferase (EC 2.5.1.18) from Xylella fastidiosa (see paper)
    27% identity, 100% coverage of query (57.0 bits)

gstA theta class glutathione S-transferase; EC 2.5.1.18 from Emericella nidulans (see paper)
    27% identity, 95% coverage of query (56.2 bits)

B3VQJ6 glutathione transferase (EC 2.5.1.18) from Phanerodontia chrysosporium (see paper)
    27% identity, 78% coverage of query (55.8 bits)

GSTd1-5 / CAB03592.1 GSTD1-5 protein from Anopheles gambiae (see 2 papers)
    23% identity, 99% coverage of query (55.1 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    29% identity, 79% coverage of query (54.7 bits)

J7JYU5 glutathione transferase (EC 2.5.1.18) from Phanerodontia chrysosporium (see paper)
    32% identity, 71% coverage of query (54.7 bits)

GST1C_ANOGA / Q93112 Glutathione S-transferase 1, isoform C; AgGst1-alpha; Aggst1-5; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see paper)
    24% identity, 99% coverage of query (54.3 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    26% identity, 92% coverage of query (53.9 bits)

4iw9B Crystal structure of glutathione s-transferase mha_0454 (target efi- 507015) from mannheimia haemolytica, gsh complex
    24% identity, 97% coverage of query (53.9 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    27% identity, 92% coverage of query (53.9 bits)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    25% identity, 84% coverage of query (53.9 bits)

1jlvA / Q7KIF2 Anopheles dirus species b glutathione s-transferases 1-3 (see paper)
    24% identity, 89% coverage of query (53.5 bits)

6hjsA / R7S6N2 Crystal structure of glutathione transferase omega 1c from trametes versicolor (see paper)
    25% identity, 89% coverage of query (53.5 bits)

4i97A / R4S8C5 The crystal structure of glutathione s-transferase sniggstd1a from scaptomyza nigrita in complex with glutathione
    26% identity, 91% coverage of query (53.5 bits)

CH_124240 putative glutathione S-transferase [Botryotinia fuckeliana] from Magnaporthe grisea 70-15 (see paper)
    25% identity, 94% coverage of query (53.1 bits)

Q8N0B3 glutathione transferase (EC 2.5.1.18) from Nilaparvata lugens (see paper)
    23% identity, 92% coverage of query (53.1 bits)

3wywB / Q8N0B3 Structural characterization of catalytic site of a nilaparvata lugens delta-class glutathione transferase (see paper)
    23% identity, 92% coverage of query (53.1 bits)

GSTE_PSEP1 / P82998 Glutathione S-transferase; EC 2.5.1.18 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
    23% identity, 91% coverage of query (52.8 bits)

3pr8A / Q88RE7 Structure of glutathione s-transferase(pp0183) from pseudomonas putida in complex with gsh
    23% identity, 91% coverage of query (52.0 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    28% identity, 83% coverage of query (52.0 bits)

GSTD5_DROME / Q9VG95 Glutathione S-transferase D5; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    24% identity, 92% coverage of query (52.0 bits)

3vwxC / Q9U795 Structural analysis of an epsilon-class glutathione s-transferase from housefly, musca domestica (see paper)
    24% identity, 86% coverage of query (50.4 bits)

4naxA / A5W1A6 Crystal structure of glutathione transferase pput_1760 from pseudomonas putida, target efi-507288, with one glutathione disulfide bound per one protein subunit
    23% identity, 96% coverage of query (50.1 bits)

4ielB / Q0B681 Crystal structure of a glutathione s-transferase family protein from burkholderia ambifaria, target efi-507141, with bound glutathione
    23% identity, 76% coverage of query (49.7 bits)

3zmkB / G0XSZ1 Anopheles funestus glutathione-s-transferase epsilon 2 (gste2) protein structure from different alelles: a single amino acid change confers high level of ddt resistance and cross resistance to permethrin in a major malaria vector in africa (see paper)
    22% identity, 87% coverage of query (49.3 bits)

4qq7A / B4E6Q3 Crystal structure of putative stringent starvation protein a from burkholderia cenocepacia with bound glutathione
    26% identity, 79% coverage of query (48.9 bits)

GST1D_ANOGA / Q93113 Glutathione S-transferase 1, isoform D; AgGst1-alpha; Aggst1-1; Aggst1-6; Aggst2-1; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see 3 papers)
1pn9A / Q93113 Crystal structure of an insect delta-class glutathione s-transferase from a ddt-resistant strain of the malaria vector anopheles gambiae (see paper)
GSTd1-6 / CAB03593.1 GSTD1-6 protein, partial from Anopheles gambiae (see 2 papers)
    24% identity, 91% coverage of query (47.0 bits)

1k0aA Ure2p in complex with s-hexylglutathione
    24% identity, 89% coverage of query (47.0 bits)

5zwpA / P28338 Crystal structure of the delta-class glutathione transferase from musca domestica (see paper)
    23% identity, 92% coverage of query (46.6 bits)

1jzrA / P23202 Ure2p in complex with glutathione (see paper)
    24% identity, 89% coverage of query (46.2 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    28% identity, 90% coverage of query (45.8 bits)

A1ZB72 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
4pngB / A1ZB72 Glutathione s-transferase from drosophila melanogaster - isozyme e7 (see paper)
    23% identity, 83% coverage of query (45.8 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    28% identity, 90% coverage of query (45.8 bits)

8a0rA Crystal structure of poplar glutathione transferase u20 in complex with pinocembrin
    27% identity, 77% coverage of query (44.7 bits)

8a0qA Crystal structure of poplar glutathione transferase u20 in complex with baicalein
    27% identity, 77% coverage of query (44.7 bits)

8a0oA Crystal structure of poplar glutathione transferase u20 in complex with galangin
    27% identity, 77% coverage of query (44.7 bits)

8a0iA Crystal structure of poplar glutathione transferase u20 in complex with glutathionylphenylacetophenone
    27% identity, 77% coverage of query (44.7 bits)

8a08A Crystal structure of poplar glutathione transferase u20 in complex with glutathione
    27% identity, 77% coverage of query (44.7 bits)

8a0pA / D2X9R3 Crystal structure of poplar glutathione transferase u20 in complex with morin (see paper)
    27% identity, 77% coverage of query (44.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory