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Searching for up to 100 curated homologs for GFF3341 FitnessBrowser__Marino:GFF3341 (232 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4y7uA / Q88QT2 Structural analysis of muru (see paper)
    59% identity, 97% coverage of query (244 bits)

murU / Q88QT2 N-acetyl-α-D-muramate 1-phosphate uridylyltransferase (EC 2.7.7.99) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
MURU_PSEPK / Q88QT2 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88QT2 N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase (EC 2.7.7.99) from Pseudomonas putida (see 5 papers)
    59% identity, 97% coverage of query (244 bits)

4y7vA Structural analysis of muru
    59% identity, 96% coverage of query (230 bits)

MURU_PSEAE / Q9I5U0 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    58% identity, 95% coverage of query (225 bits)

MURU_NEIMB / Q9JXY0 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
    50% identity, 93% coverage of query (198 bits)

Build an alignment

Build an alignment for GFF3341 and 5 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

GMPPB_HUMAN / Q9Y5P6 Mannose-1-phosphate guanyltransferase beta; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta; EC 2.7.7.13 from Homo sapiens (Human) (see 4 papers)
Q9Y5P6 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Homo sapiens (see paper)
7d72K / Q9Y5P6 Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
    28% identity, 98% coverage of query (87.8 bits)

7d73E Cryo-em structure of gmppa/gmppb complex bound to gtp (state i)
    28% identity, 98% coverage of query (87.8 bits)

7d72E Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose
    28% identity, 98% coverage of query (87.8 bits)

HDDC_CAMJE / Q0P8J1 D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase; D-alpha-D-heptose 1-phosphate guanylyltransferase; EC 2.7.7.71 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    27% identity, 91% coverage of query (86.3 bits)

GMPPB_PIG / P0C5I2 Mannose-1-phosphate guanyltransferase beta; GDP-mannose pyrophosphorylase 37-kDa subunit; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta; EC 2.7.7.13 from Sus scrofa (Pig) (see 2 papers)
    27% identity, 98% coverage of query (85.9 bits)

MPG1_SCHPO / O74484 Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase; GTP-mannose-1-phosphate guanylyltransferase; EC 2.7.7.13 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
mpg1 / RF|NP_588405.1 mannose-1-phosphate guanyltransferase Mpg1; EC 2.7.7.13 from Schizosaccharomyces pombe (see 2 papers)
    29% identity, 91% coverage of query (85.1 bits)

CUGP_SYNY3 / P74285 UTP--glucose-1-phosphate uridylyltransferase; Cyanobacterial UDP-glucose pyrophosphorylase; UDP-glucose pyrophosphorylase; UDP-Glc PPase; EC 2.7.7.9 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
P74285 UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) from Synechocystis sp. (see paper)
    31% identity, 94% coverage of query (84.0 bits)

Q941T9 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Oryza sativa Japonica Group (see paper)
    29% identity, 100% coverage of query (82.8 bits)

ptmE / Q0P8S9 glucosamine-1-phosphate guanylyltransferase from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    25% identity, 91% coverage of query (81.3 bits)

7whsA / E9BG32 Cryo-em structure of leishmanial gdp-mannose pyrophosphorylase in complex with gtp (see paper)
    27% identity, 91% coverage of query (81.3 bits)

MURU_CAUVC / Q9A2M1 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
    32% identity, 91% coverage of query (80.5 bits)

ravd / D1H0J0 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) from Streptomyces ravidus (see 2 papers)
    30% identity, 97% coverage of query (78.2 bits)

5z09A St0452(y97n)-utp binding form
    28% identity, 91% coverage of query (75.9 bits)

Q400H3 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) from Thermus caldophilus (see paper)
    27% identity, 95% coverage of query (74.3 bits)

hddC / Q9AGY6 D-glycero-D-α-manno-heptose 1-phosphate guanylyltransferase (EC 2.7.7.71) from Aneurinibacillus thermoaerophilus (see paper)
HDDC_ANETH / Q9AGY6 D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase; D-alpha-D-heptose 1-phosphate guanylyltransferase; EC 2.7.7.71 from Aneurinibacillus thermoaerophilus (see paper)
Q9AGY6 D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase (EC 2.7.7.71) from Aneurinibacillus thermoaerophilus (see paper)
    26% identity, 95% coverage of query (74.3 bits)

ST0452 / Q975F9 multifunctional glucose-1-phosphate thymidylyltransferase/hexosamine-1-phosphate N-acetyltransferase/UDP-N-acetylhexosamine diphosphorylase (EC 2.7.7.24; EC 2.7.7.23; EC 2.7.7.83; EC 2.3.1.157; EC 2.3.1.276) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see 2 papers)
S1PNA_SULTO / Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 5 papers)
Q975F9 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); galactosamine-1-phosphate N-acetyltransferase (EC 2.3.1.276); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23); glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24); aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37); UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83); UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) from Sulfurisphaera tokodaii (see 7 papers)
2ggqA / Q975F9 Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
    28% identity, 91% coverage of query (72.4 bits)

lmbO / A9Y8S7 octose 1-phosphate guanylyltransferase from Streptomyces lincolnensis (see 2 papers)
    31% identity, 75% coverage of query (71.2 bits)

GLMU_METJA / Q58501 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
    29% identity, 91% coverage of query (69.3 bits)

Q63R79 D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase (EC 2.7.7.71) from Burkholderia pseudomallei (see paper)
    26% identity, 91% coverage of query (65.1 bits)

orf6 / A0A0A8J873 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-gulopyranose hydrolase from Escherichia coli (see paper)
    26% identity, 89% coverage of query (64.3 bits)

RMLA_BACSU / P39629 Glucose-1-phosphate thymidylyltransferase; Spore coat polysaccharide biosynthesis protein SpsI; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase; EC 2.7.7.24 from Bacillus subtilis (strain 168) (see paper)
    26% identity, 92% coverage of query (57.8 bits)

3hl3A / A0A6L8PCC3 2.76 angstrom crystal structure of a putative glucose-1-phosphate thymidylyltransferase from bacillus anthracis in complex with a sucrose.
    27% identity, 93% coverage of query (55.5 bits)

4ecmA 2.3 angstrom crystal structure of a glucose-1-phosphate thymidylyltransferase from bacillus anthracis in complex with thymidine-5-diphospho-alpha-d-glucose and pyrophosphate
    27% identity, 93% coverage of query (55.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory