Searching for up to 100 curated homologs for GFF3429 PS417_17545 2-oxoisovalerate dehydrogenase (411 a.a.)
Found high-coverage hits (≥70%) to 52 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
AO356_22990 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
93% identity, 100% coverage of query (806 bits)
Pf6N2E2_481 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
92% identity, 100% coverage of query (802 bits)
AO353_26635 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E3
96% identity, 100% coverage of query (795 bits)
PfGW456L13_3540 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
95% identity, 100% coverage of query (788 bits)
bkdA1 / GI|790514 2-oxoisovalerate dehydrogenase subunit alpha; EC 1.2.4.4 from Pseudomonas putida (see 4 papers)
86% identity, 100% coverage of query (747 bits)
1qs0A / P09060 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
86% identity, 99% coverage of query (744 bits)
SMc03201 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Sinorhizobium meliloti 1021
61% identity, 99% coverage of query (515 bits)
P50136 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Mus musculus (see paper)
39% identity, 86% coverage of query (233 bits)
ODBA_RAT / P11960 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Rattus norvegicus (Rat) (see paper)
39% identity, 86% coverage of query (232 bits)
BCKDHA / P12694 branched-chain α-keto acid dehydrogenase E1 component α subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBA_HUMAN / P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Homo sapiens (Human) (see 13 papers)
P12694 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
38% identity, 86% coverage of query (223 bits)
ODBA_BOVIN / P11178 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
37% identity, 86% coverage of query (222 bits)
2bffA / P12694 Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch (see paper)
37% identity, 86% coverage of query (221 bits)
ODBA1_ARATH / Q9LPL5 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 86% coverage of query (221 bits)
1wciA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
38% identity, 86% coverage of query (218 bits)
2bewA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
38% identity, 86% coverage of query (218 bits)
2bevA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
38% identity, 86% coverage of query (218 bits)
2beuA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
38% identity, 86% coverage of query (218 bits)
1dtwA Human branched-chain alpha-keto acid dehydrogenase
37% identity, 86% coverage of query (218 bits)
ODBA2_ARATH / Q84JL2 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
38% identity, 85% coverage of query (216 bits)
ODBA_CAEEL / O45924 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; EC 1.2.4.4 from Caenorhabditis elegans (see paper)
38% identity, 80% coverage of query (204 bits)
1umbA / Q5SLR4 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
36% identity, 85% coverage of query (200 bits)
ODBA_THET8 / Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
36% identity, 85% coverage of query (200 bits)
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
36% identity, 85% coverage of query (200 bits)
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
36% identity, 85% coverage of query (200 bits)
1v1mA / P12694 Crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine (see paper)
35% identity, 86% coverage of query (198 bits)
Q72GU1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Thermus thermophilus (see paper)
36% identity, 85% coverage of query (197 bits)
1oluA Roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase
34% identity, 86% coverage of query (192 bits)
2bfcA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
34% identity, 86% coverage of query (192 bits)
Q9HIA3 branched-chain-2-oxoacid decarboxylase (subunit 1/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
33% identity, 81% coverage of query (181 bits)
ppdcα / A0A222AKA3 phenylpyruvate decarboxylase α subunit (EC 4.1.1.43) from Streptomyces virginiae (see paper)
A0A222AKA3 phenylpyruvate decarboxylase (EC 4.1.1.43) from Streptomyces virginiae (see paper)
35% identity, 80% coverage of query (179 bits)
Q7NAZ8 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mycoplasma gallisepticum (see paper)
30% identity, 86% coverage of query (176 bits)
3dufA / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
34% identity, 81% coverage of query (173 bits)
ODPA_BACCE / Q4MTG0 Pyruvate dehydrogenase E1 component subunit alpha; EC 1.2.4.1 from Bacillus cereus (see paper)
32% identity, 85% coverage of query (170 bits)
pdhA / AAC24932.1 pyruvate decarboxylase E-1 alpha subunit from Bacillus subtilis (see 3 papers)
32% identity, 85% coverage of query (167 bits)
pdhA / P75390 α subunit from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (see 3 papers)
30% identity, 86% coverage of query (167 bits)
BKDA_MYCTU / P9WIS3 3-methyl-2-oxobutanoate dehydrogenase subunit alpha; Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha; BCKADH E1-alpha; EC 1.2.4.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
34% identity, 81% coverage of query (164 bits)
1w85A The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
32% identity, 81% coverage of query (164 bits)
3dv0A Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
33% identity, 81% coverage of query (157 bits)
Q53592 branched-chain alpha-keto acid dehydrogenase system (EC 1.2.1.25) from Streptomyces avermitilis (see paper)
33% identity, 81% coverage of query (152 bits)
3dv0E / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
32% identity, 81% coverage of query (145 bits)
bfmBAA / P37940 2-keto-isovalerate dehydrogenase component α subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
34% identity, 71% coverage of query (143 bits)
1w88A The crystal structure of pyruvate dehydrogenase e1(d180n,e183q) bound to the peripheral subunit binding domain of e2
32% identity, 81% coverage of query (142 bits)
Build an alignment for GFF3429 and 42 homologs with ≥ 30% identity
Or download the sequences
Q46142 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoA TPP-dependent acetoin dehydrogenase complex, E1 component, alpha subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21744.1 TPP-dependent acetoin dehydrogenase alpha-subunit from Clostridium magnum (see paper)
29% identity, 77% coverage of query (139 bits)
ODPA_YEAST / P16387 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P16387 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Saccharomyces cerevisiae (see 2 papers)
28% identity, 79% coverage of query (112 bits)
A2XPT6 pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
25% identity, 76% coverage of query (106 bits)
acoA / Q3A7P1 acetoin:DCPIP oxidoreductase α subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
acoA / AAA18915.1 acetoin:DCPIP oxidoreductase alpha subunit from Pelobacter carbinolicus (see paper)
29% identity, 73% coverage of query (103 bits)
Q10489 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; PDHE1-A; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
27% identity, 81% coverage of query (103 bits)
ODPA_CHATD / G0SHF3 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 2 papers)
G0SHF3 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Chaetomium thermophilum (see paper)
27% identity, 78% coverage of query (101 bits)
pdhB pyruvate dehydrogenase (lipoamide) from Emericella nidulans (see 2 papers)
26% identity, 78% coverage of query (96.3 bits)
ODPA_MOUSE / P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Mus musculus (Mouse) (see 6 papers)
P35486 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mus musculus (see 2 papers)
27% identity, 84% coverage of query (94.7 bits)
ODPAT_HUMAN / P29803 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; PDHE1-A type II; EC 1.2.4.1 from Homo sapiens (Human) (see 5 papers)
26% identity, 75% coverage of query (90.5 bits)
P26267 Pyruvate dehydrogenase E1 component subunit alpha type I, mitochondrial; PDHA1; PDHE1-A; EC 1.2.4.1 from Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
24% identity, 78% coverage of query (84.0 bits)
Or start over
Lawrence Berkeley National Laboratory