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Searching for up to 100 curated homologs for GFF3448 FitnessBrowser__psRCH2:GFF3448 (379 a.a.)

Found high-coverage hits (≥70%) to 19 curated proteins.

Removed hits that are identical to the query, leaving 18

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SO1963 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Shewanella oneidensis MR-1
    31% identity, 96% coverage of query (159 bits)

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Build an alignment for GFF3448 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

PfGW456L13_4962 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens GW456-L13
    25% identity, 76% coverage of query (79.0 bits)

AO353_15550 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E3
    24% identity, 76% coverage of query (78.2 bits)

HGD_RHIME / Q9X4F5 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    25% identity, 88% coverage of query (77.8 bits)

Pf6N2E2_5290 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E2
    24% identity, 76% coverage of query (75.9 bits)

HGD_PSEPK / Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88E47 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas putida (see paper)
    25% identity, 74% coverage of query (70.9 bits)

HGD_PSEPU / Q6EMI9 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    24% identity, 81% coverage of query (70.9 bits)

4aq6D / Q88E47 Substrate bound homogentisate 1,2-dioxygenase (see paper)
    25% identity, 74% coverage of query (70.9 bits)

3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    25% identity, 74% coverage of query (70.9 bits)

3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    25% identity, 74% coverage of query (70.9 bits)

3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    25% identity, 74% coverage of query (70.9 bits)

HMGA_ASPFU / Q4WHT9 Homogentisate 1,2-dioxygenase hmgA; Homogentisate oxygenase hmgA; Homogentisic acid oxidase hmgA; Homogentisicase hmgA; L-tyrosine degradation gene cluster protein hmgA; Pyomelanin biosynthesis cluster protein hmgA; EC 1.13.11.5 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    24% identity, 71% coverage of query (66.6 bits)

HGD / Q93099 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Homo sapiens (see paper)
HGD_HUMAN / Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 14 papers)
    23% identity, 72% coverage of query (65.5 bits)

HGD_CAEEL / Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
    23% identity, 81% coverage of query (64.7 bits)

RR42_RS31275 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Cupriavidus basilensis FW507-4G11
    24% identity, 72% coverage of query (64.7 bits)

HGD_MOUSE / O09173 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Mus musculus (Mouse) (see paper)
    22% identity, 72% coverage of query (63.2 bits)

1ey2A / Q93099 Human homogentisate dioxygenase with fe(ii) (see paper)
    23% identity, 72% coverage of query (62.0 bits)

B8YB76 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Bos taurus (see 2 papers)
    22% identity, 72% coverage of query (60.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory