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Searching for up to 100 curated homologs for GFF3489 FitnessBrowser__WCS417:GFF3489 (266 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7et9A / A0A8I1ZEE8 Crystal structure of abhpai-zn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
    68% identity, 94% coverage of query (357 bits)

7etiA Crystal structure of abhpai-zn-pyruvate-4-hydroxybenzaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7etfA Crystal structure of abhpai-mn-pyruvate-succinic semialdehyde complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7eteA Crystal structure of abhpai-mg-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7etdA Crystal structure of abhpai-zn-(4s)-kdglu complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7etcA Crystal structure of abhpai-zn-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7etbA Crystal structure of abhpai-mn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7etaA Crystal structure of abhpai-co-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

7ethA Crystal structure of abhpai-zn-pyruvate-propionaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii
    68% identity, 94% coverage of query (357 bits)

HPCH_ECOLX / Q47098 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase; EC 4.1.2.52 from Escherichia coli (see 3 papers)
B1IS70 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52) from Escherichia coli (see paper)
Q47098 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52); 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (see 3 papers)
    70% identity, 88% coverage of query (333 bits)

2v5kA / Q47098 Class ii aldolase hpch - magnesium - oxamate complex (see paper)
    70% identity, 88% coverage of query (333 bits)

4b5vA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with 4-hydroxyl-2-ketoheptane-1,7-dioate
    70% identity, 88% coverage of query (333 bits)

4b5tA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with ketobutyrate
    70% identity, 88% coverage of query (333 bits)

4b5sA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with pyruvate
    70% identity, 88% coverage of query (333 bits)

2vwtA / P76469 Crystal structure of yfau, a metal ion dependent class ii aldolase from escherichia coli k12 - mg-pyruvate product complex (see paper)
    60% identity, 94% coverage of query (305 bits)

YfaU / b2245 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yfaU / P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli (strain K12) (see 4 papers)
RHMA_ECOLI / P76469 2-keto-3-deoxy-L-rhamnonate aldolase; KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; EC 4.1.2.53 from Escherichia coli (strain K12) (see 2 papers)
P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli (see 3 papers)
    61% identity, 94% coverage of query (304 bits)

BPHF_RHOJR / O05151 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.39 from Rhodococcus jostii (strain RHA1) (see paper)
    56% identity, 96% coverage of query (279 bits)

YhaF / b3126 α-dehydro-β-deoxy-D-glucarate aldolase (EC 4.1.2.20) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
garL / P23522 α-dehydro-β-deoxy-D-glucarate aldolase (EC 4.1.2.20) from Escherichia coli (strain K12) (see 2 papers)
GARL_ECOLI / P23522 5-keto-4-deoxy-D-glucarate aldolase; KDGluc aldolase; KDGlucA; 2-dehydro-3-deoxy-D-glucarate aldolase; 2-keto-3-deoxy-D-glucarate aldolase; 5-dehydro-4-deoxy-D-glucarate aldolase; Alpha-keto-beta-deoxy-D-glucarate aldolase; EC 4.1.2.20 from Escherichia coli (strain K12) (see 3 papers)
    46% identity, 95% coverage of query (228 bits)

1dxeA / P23522 2-dehydro-3-deoxy-galactarate aldolase from escherichia coli (see paper)
    46% identity, 95% coverage of query (228 bits)

1dxfA 2-dehydro-3-deoxy-galactarate aldolase from escherichia coli in complex with pyruvate
    46% identity, 95% coverage of query (228 bits)

KDSGA_PSEPU / P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase; 2-keto-3,6-dideoxy-6-sulfogluconate aldolase; KDSG aldolase; EC 4.1.2.58 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase (EC 4.1.2.58) from Pseudomonas putida (see paper)
    42% identity, 96% coverage of query (197 bits)

8adqA / A0A9J9HGY6 Crystal structure of holo-swhpa-mg (hydroxy ketone aldolase) from sphingomonas wittichii rw1 in complex with hydroxypyruvate and d- glyceraldehyde (see paper)
    35% identity, 89% coverage of query (119 bits)

7nr1A Crystal structure of holo-s116a mutant of hydroxy ketone aldolase (swhka) from sphingomonas wittichii rw1 (see paper)
    35% identity, 89% coverage of query (119 bits)

7o5rA Crystal structure of holo-swhpa-mn (hydroxyketoacid aldolase) from sphingomonas wittichii rw1
    35% identity, 89% coverage of query (119 bits)

Build an alignment

Build an alignment for GFF3489 and 24 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

A0A0H3K9Z0 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Staphylococcus aureus (see paper)
    29% identity, 91% coverage of query (94.0 bits)

4tv5A / A0A0H3K9Z0 Crystal structure of citrate synthase sbng (see paper)
    28% identity, 91% coverage of query (90.5 bits)

CGHB_CHAGB / Q2HBN5 4-hydroxy-4-methyl-2-oxoglutarate aldolase cghB; Sch210972 biosynthesis cluster protein B; EC 4.1.3.17 from Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) (see paper)
    32% identity, 71% coverage of query (83.6 bits)

4tv6A Crystal structure of citrate synthase variant sbng e151q
    27% identity, 91% coverage of query (82.4 bits)

TASA_HAPIR / A0A0F7GG11 4-hydroxy-4-methyl-2-oxoglutarate aldolase tasA; Tetramic acid Sch210971/2 biosynthesis cluster protein A; EC 4.1.3.17 from Hapsidospora irregularis (see paper)
    31% identity, 85% coverage of query (81.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory