Searching for up to 100 curated homologs for GFF354 FitnessBrowser__Phaeo:GFF354 (320 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
3gvhA / Q2YLR9 Crystal structure of lactate/malate dehydrogenase from brucella melitensis
78% identity, 99% coverage of query (502 bits)
mdh / Q84FY8 malate dehydrogenase subunit (EC 1.1.1.37) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see paper)
Q84FY8 malate dehydrogenase (EC 1.1.1.37) from Methylorubrum extorquens (see paper)
77% identity, 100% coverage of query (496 bits)
4rosA / A9W386 Crystal structure of methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose
77% identity, 99% coverage of query (493 bits)
5ujkA Malate dehydrogenase from methylobacterium extorquens, complexed with NAD
77% identity, 98% coverage of query (492 bits)
3gviA Crystal structure of lactate/malate dehydrogenase from brucella melitensis in complex with adp
76% identity, 99% coverage of query (485 bits)
U80676 / P93052 acyl-CoA reductase (NADH) from Botryococcus braunii (see 2 papers)
70% identity, 100% coverage of query (459 bits)
4pltB / A0A075B5H0 Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate. (see paper)
64% identity, 97% coverage of query (424 bits)
4plyA Crystal structure of ancestral apicomplexan malate dehydrogenase with malate.
64% identity, 97% coverage of query (424 bits)
4plfB / A0A075B5G8 Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate. (see paper)
58% identity, 98% coverage of query (385 bits)
4plcA Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
58% identity, 98% coverage of query (385 bits)
6vdjA Crystal structure of ancestral apicomplexan lactate dehydrogenase with sulfate and nadh4.
61% identity, 98% coverage of query (382 bits)
P49814 Malate dehydrogenase; Vegetative protein 69; VEG69; EC 1.1.1.37 from Bacillus subtilis (strain 168)
54% identity, 97% coverage of query (352 bits)
Q8I8U5 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria acervulina (see paper)
52% identity, 99% coverage of query (347 bits)
7byaA Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and adenosine 5'- diphosphoribose (apr)
53% identity, 97% coverage of query (341 bits)
7by9A Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and nicotinamide adenine dinucleotide (NAD)
53% identity, 97% coverage of query (341 bits)
7f8dA / A0A143T1U9 Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) g218y mutant (see paper)
53% identity, 97% coverage of query (340 bits)
MDH_THET7 / A0A0S3QTC6 Malate dehydrogenase; MDH; EC 1.1.1.37 from Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6) (see paper)
53% identity, 96% coverage of query (340 bits)
Q27797 L-lactate dehydrogenase (EC 1.1.1.27) from Toxoplasma gondii (see paper)
52% identity, 95% coverage of query (330 bits)
1sowA T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate
52% identity, 95% coverage of query (329 bits)
3czmB / Q27797 T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq
52% identity, 95% coverage of query (328 bits)
2hjrB / Q5CYZ3 Crystal structure of cryptosporidium parvum malate dehydrogenase (see paper)
52% identity, 98% coverage of query (320 bits)
1uxgA / P80040 Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface. (see paper)
50% identity, 98% coverage of query (316 bits)
MDH_CHLTE / P80039 Malate dehydrogenase; EC 1.1.1.37 from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum) (see paper)
50% identity, 98% coverage of query (315 bits)
MDH_CHLAA / P80040 Malate dehydrogenase; EC 1.1.1.37 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see 3 papers)
49% identity, 98% coverage of query (315 bits)
Q7Z0X7 L-lactate dehydrogenase (EC 1.1.1.27) from Babesia bovis (see paper)
CH_024078 L-lactate dehydrogenase; EC 1.1.1.27 from Babesia bovis T2Bo (see paper)
49% identity, 96% coverage of query (311 bits)
2fn7A / Q5CYZ2 Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b- nicotinamide adenine dinucleotide)
51% identity, 96% coverage of query (307 bits)
4nd2A Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor analog (3-acetylpyridine adenine dinucleotide)
51% identity, 96% coverage of query (307 bits)
Q9GT92 L-lactate dehydrogenase (EC 1.1.1.27) from Cryptosporidium parvum (see 2 papers)
51% identity, 96% coverage of query (306 bits)
Q8I8U4 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria tenella (see paper)
51% identity, 95% coverage of query (306 bits)
1guzA / P0C890,P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
49% identity, 97% coverage of query (302 bits)
6ct6B / U6M598 Crystal structure of lactate dehydrogenase from eimeria maxima with nadh and oxamate
45% identity, 98% coverage of query (300 bits)
Q8I8U3 L-lactate dehydrogenase (EC 1.1.1.27) from Eimeria maxima (see paper)
45% identity, 98% coverage of query (300 bits)
1gv0A / P80039 Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
49% identity, 97% coverage of query (298 bits)
MDH_PROVB / P0C890 Malate dehydrogenase; EC 1.1.1.37 from Prosthecochloris vibrioformis (Chlorobium vibrioforme) (see paper)
47% identity, 98% coverage of query (296 bits)
2a92C / Q4PRK9 Crystal structure of lactate dehydrogenase from plasmodium vivax: complex with nadh (see paper)
44% identity, 95% coverage of query (280 bits)
Q6VVP7 malate dehydrogenase (EC 1.1.1.37) from Plasmodium falciparum (see paper)
GI|46361136 malate dehydrogenase; EC 1.1.1.37 from Plasmodium falciparum 3D7 (see paper)
45% identity, 95% coverage of query (278 bits)
6r8gC / Q6VVP7 Crystal structure of malate dehydrogenase from plasmodium falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine
45% identity, 95% coverage of query (278 bits)
LDH lactate dehydrogenase; EC 1.1.1.27 from Plasmodium falciparum (see paper)
LDH / GB|ABA46354.1 lactate dehydrogenase; EC 1.1.1.27 from Plasmodium falciparum (see paper)
44% identity, 95% coverage of query (277 bits)
2a94A Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh.
44% identity, 95% coverage of query (277 bits)
1t2dA Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate
44% identity, 95% coverage of query (277 bits)
1t25A Plasmodium falciparum lactate dehydrogenase complexed with nadh and 3- hydroxyisoxazole-4-carboxylic acid
44% identity, 95% coverage of query (277 bits)
1t24A Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid
44% identity, 95% coverage of query (277 bits)
3zh2A Structure of plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer
44% identity, 95% coverage of query (277 bits)
4b7uA Plasmodium falciparum l-lactate dehydrogenase complexed with bicine
44% identity, 95% coverage of query (277 bits)
1t26A Plasmodium falciparum lactate dehydrogenase complexed with nadh and 4- hydroxy-1,2,5-thiadiazole-3-carboxylic acid
44% identity, 95% coverage of query (277 bits)
6txrA Structural insights into cubane-modified aptamer recognition of a malaria biomarker
44% identity, 95% coverage of query (276 bits)
6txrB Structural insights into cubane-modified aptamer recognition of a malaria biomarker
44% identity, 95% coverage of query (275 bits)
LDH_PLABA / Q7SI97 L-lactate dehydrogenase; EC 1.1.1.27 from Plasmodium berghei (strain Anka) (see paper)
43% identity, 94% coverage of query (274 bits)
1oc4A Lactate dehydrogenase from plasmodium berghei
43% identity, 94% coverage of query (274 bits)
1u4sA Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedisulphonic acid
44% identity, 95% coverage of query (273 bits)
1u4oA Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedicarboxylic acid
44% identity, 95% coverage of query (273 bits)
1xivA Plasmodium falciparum lactate dehydrogenase complexed with 2-({4- chloro-[hydroxy(methoxy)methyl]cyclohexyl}amino)ethane-1,1,2-triol
44% identity, 95% coverage of query (272 bits)
1u5aA Plasmodium falciparum lactate dehydrogenase complexed with 3,5- dihydroxy-2-naphthoic acid
44% identity, 95% coverage of query (272 bits)
4b7uB Plasmodium falciparum l-lactate dehydrogenase complexed with bicine
44% identity, 95% coverage of query (272 bits)
1u5cA Plasmodium falciparum lactate dehydrogenase complexed with 3,7- dihydroxynaphthalene-2-carboxylic acid and NAD+
44% identity, 95% coverage of query (272 bits)
P90613 L-lactate dehydrogenase (EC 1.1.1.27) from Toxoplasma gondii (see 2 papers)
47% identity, 97% coverage of query (270 bits)
3om9A / P90613 T. Gondii bradyzoite-specific ldh (ldh1) in complex with NAD and oxq
47% identity, 97% coverage of query (270 bits)
1pzgA T.Gondii ldh1 complexed with apad and sulfate at 1.6 angstroms
47% identity, 97% coverage of query (270 bits)
1pzfA T.Gondii ldh1 ternary complex with apad+ and oxalate
47% identity, 97% coverage of query (270 bits)
1cetA Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.
43% identity, 95% coverage of query (267 bits)
1t2eA / Q27743 Plasmodium falciparum lactate dehydrogenase s245a, a327p mutant complexed with nadh and oxamate (see paper)
44% identity, 95% coverage of query (265 bits)
MDH_FLAFR / Q25QU7 Malate dehydrogenase; EC 1.1.1.37 from Flavobacterium frigidimaris (see 2 papers)
40% identity, 97% coverage of query (263 bits)
MDH_AERPE / Q9YEA1 Malate dehydrogenase; EC 1.1.1.299 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
40% identity, 96% coverage of query (246 bits)
A3MWU9 malate dehydrogenase (EC 1.1.1.37) from Pyrobaculum calidifontis (see paper)
36% identity, 95% coverage of query (212 bits)
MDH_PYRIL / A1RS58 Malate dehydrogenase; EC 1.1.1.37 from Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) (see paper)
35% identity, 96% coverage of query (210 bits)
4ln1B / Q81EP4 Crystal structure of l-lactate dehydrogenase from bacillus cereus atcc 14579 complexed with calcium, nysgrc target 029452
34% identity, 94% coverage of query (196 bits)
ldh / P00343 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Lactobacillus casei (see 2 papers)
LDH_LACCA / P00343 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lacticaseibacillus casei (Lactobacillus casei) (see 3 papers)
33% identity, 95% coverage of query (187 bits)
A0A2U9AUU1 L-lactate dehydrogenase (EC 1.1.1.27) from Lacticaseibacillus casei (see paper)
33% identity, 94% coverage of query (186 bits)
6j9tB Complex structure of lactobacillus casei lactate dehydrogenase with fructose-1,6-bisphosphate
33% identity, 95% coverage of query (186 bits)
1llcA / P00343 Structure determination of the allosteric l-lactate dehydrogenase from lactobacillus casei at 3.0 angstroms resolution
32% identity, 95% coverage of query (184 bits)
Q5FMB0 L-lactate dehydrogenase (EC 1.1.1.27) from Lactobacillus acidophilus (see paper)
33% identity, 96% coverage of query (181 bits)
LDH_LACHE / O32765 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
33% identity, 96% coverage of query (181 bits)
LDH_PEDAC / Q59645 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Pediococcus acidilactici (see paper)
34% identity, 95% coverage of query (181 bits)
ldh1 L-lactate dehydrogenase 1; EC 1.1.1.27 from Lactobacillus plantarum (see paper)
32% identity, 96% coverage of query (179 bits)
LDH_LACPE / P56511 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactiplantibacillus pentosus (Lactobacillus pentosus) (see 2 papers)
ldh L-lactate dehydrogenase; EC 1.1.1.27 from Lactobacillus pentosus (see paper)
32% identity, 96% coverage of query (178 bits)
B9MKZ8 L-lactate dehydrogenase (EC 1.1.1.27) from Caldicellulosiruptor bescii (see paper)
33% identity, 98% coverage of query (178 bits)
1ez4B / P56511 Crystal structure of non-allosteric l-lactate dehydrogenase from lactobacillus pentosus at 2.3 angstrom resolution (see paper)
32% identity, 96% coverage of query (178 bits)
LDH_THEMA / P16115 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
33% identity, 96% coverage of query (177 bits)
LDH1_STAAE / A6QDL6 L-lactate dehydrogenase 1; L-LDH 1; EC 1.1.1.27 from Staphylococcus aureus (strain Newman) (see paper)
LDH1_STAAC / Q5HJD7 L-lactate dehydrogenase 1; L-LDH 1; EC 1.1.1.27 from Staphylococcus aureus (strain COL) (see paper)
32% identity, 95% coverage of query (177 bits)
1a5zA / P16115 Lactate dehydrogenase from thermotoga maritima (tmldh) (see paper)
33% identity, 96% coverage of query (177 bits)
3h3jB / Q5HJD7 Crystal structure of lactate dehydrogenase mutant (a85r) from staphylococcus aureus complexed with NAD and pyruvate
32% identity, 95% coverage of query (177 bits)
W8CXQ9 L-lactate dehydrogenase (EC 1.1.1.27) from Weizmannia coagulans (see paper)
33% identity, 94% coverage of query (177 bits)
A0A1A6GB48 L-lactate dehydrogenase (EC 1.1.1.27) from Enterococcus mundtii (see paper)
33% identity, 98% coverage of query (177 bits)
LDH_LACLN / D8KFT1 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Lactococcus lactis subsp. cremoris (strain NZ9000) (see paper)
30% identity, 97% coverage of query (176 bits)
1ldnA / P00344 Structure of a ternary complex of an allosteric lactate dehydrogenase from bacillus stearothermophilus at 2.5 angstroms resolution (see paper)
33% identity, 95% coverage of query (175 bits)
LDH_GEOSE / P00344 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
33% identity, 95% coverage of query (175 bits)
LDH_BACSU / P13714 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Bacillus subtilis (strain 168) (see paper)
32% identity, 96% coverage of query (174 bits)
3pqdB / P13714 Crystal structure of l-lactate dehydrogenase from bacillus subtilis complexed with fbp and NAD+
32% identity, 96% coverage of query (174 bits)
P00345 L-lactate dehydrogenase (EC 1.1.1.27) from Priestia megaterium (see paper)
30% identity, 94% coverage of query (174 bits)
Q8CMZ0 L-lactate dehydrogenase (EC 1.1.1.27) from Staphylococcus epidermidis (see paper)
30% identity, 97% coverage of query (169 bits)
6j9uA Complex structure of lactobacillus casei lactate dehydrogenase penta mutant with pyruvate
31% identity, 95% coverage of query (169 bits)
ldh / P26283 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 4 papers)
P26283 L-lactate dehydrogenase (EC 1.1.1.27) from Streptococcus mutans serotype c (see paper)
31% identity, 96% coverage of query (167 bits)
LDH2_STAAE / A6QK89 L-lactate dehydrogenase 2; L-LDH 2; EC 1.1.1.27 from Staphylococcus aureus (strain Newman) (see paper)
LDH2_STAAC / Q5HCV0 L-lactate dehydrogenase 2; L-LDH 2; EC 1.1.1.27 from Staphylococcus aureus (strain COL) (see paper)
32% identity, 97% coverage of query (165 bits)
LDH_STRPN / P0A3M9 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
LDH_STRP2 / Q04K99 L-lactate dehydrogenase; L-LDH; EC 1.1.1.27 from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
31% identity, 97% coverage of query (164 bits)
mdh / O26290 NAD(P)-dependent malate dehydrogenase (EC 1.1.1.299) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
30% identity, 94% coverage of query (160 bits)
1lldA / E8ME30 Molecular basis of allosteric activation of bacterial l-lactate dehydrogenase (see paper)
32% identity, 94% coverage of query (160 bits)
Build an alignment for GFF354 and 96 homologs with ≥ 30% identity
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3wswA / V5XPB8 Crystal structure of minor l-lactate dehydrogenase from enterococcus mundtii in the ligands-bound form (see paper)
29% identity, 97% coverage of query (160 bits)
1lthR T and r states in the crystals of bacterial l-lactate dehydrogenase reveal the mechanism for allosteric control
32% identity, 94% coverage of query (160 bits)
2ldbA Structure determination and refinement of bacillus stearothermophilus lactate dehydrogenase
31% identity, 95% coverage of query (160 bits)
ldh2 / E8ME30 L-lactate dehydrogenase subunit (EC 1.1.1.27) from Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) (see 2 papers)
LDH2_BIFL2 / E8ME30 L-lactate dehydrogenase 2; L-LDH 2; FBP-dependent LDH; EC 1.1.1.27 from Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) (see 2 papers)
32% identity, 94% coverage of query (159 bits)
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Lawrence Berkeley National Laboratory