Searching for up to 100 curated homologs for GFF3641 PGA1_262p00450 sugar ABC transporter, ATP-binding protein (260 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 99
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
FRCA_RHIML / Q9F9B0 Fructose import ATP-binding protein FrcA; EC 7.5.2.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
TC 3.A.1.2.7 / Q9F9B0 FrcA, component of Fructose/mannose/ribose porter from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
40% identity, 95% coverage of query (195 bits)
TC 3.A.1.2.24 / O50504 Probable ABC-transport system ATP binding protein, component of XylFGH downstream of characterized transcriptional regulator, ROK7B7 (Sco6008); XylF (Sco6009); XylG (Sco6010); XylH (Sco6011)) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
40% identity, 92% coverage of query (192 bits)
RR42_RS03360 fructose ABC transporter, ATPase component (FrcA) from Cupriavidus basilensis FW507-4G11
43% identity, 91% coverage of query (192 bits)
TC 3.A.1.2.13 / A6VKS8 RbsA, component of The probable autoinducer-2 (AI-2;, a furanosyl borate diester: 3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Shao et al., 2007) (50-70% identical to RbsABC of E. coli; TC# 3.A.1.2.1) from Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
40% identity, 93% coverage of query (187 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
40% identity, 91% coverage of query (187 bits)
HSERO_RS05250 ABC transporter for L-fucose, ATPase component from Herbaspirillum seropedicae SmR1
40% identity, 91% coverage of query (186 bits)
XYLG_SULAC / P0DTT6 Xylose/arabinose import ATP-binding protein XylG; EC 7.5.2.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
47% identity, 84% coverage of query (184 bits)
TC 3.A.1.2.19 / Q9X051 Ribose import ATP-binding protein RbsA 2, component of D-ribose porter (Nanavati et al., 2006). Induced by ribose from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
40% identity, 91% coverage of query (182 bits)
HSERO_RS03640 D-mannose ABC transporter, ATPase component from Herbaspirillum seropedicae SmR1
39% identity, 92% coverage of query (182 bits)
TC 3.A.1.2.20 / G4FGN3 Monosaccharide-transporting ATPase, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
38% identity, 91% coverage of query (180 bits)
FRUK_BIFLO / Q8G847 Fructose import ATP-binding protein FruK; EC 7.5.2.- from Bifidobacterium longum (strain NCC 2705) (see paper)
39% identity, 94% coverage of query (179 bits)
PGA1_c07320 Inositol transport system ATP-binding protein from Phaeobacter inhibens BS107
38% identity, 93% coverage of query (176 bits)
Shewana3_2074 L-arabinose ABC transporter, ATPase component AraV from Shewanella sp. ANA-3
42% identity, 84% coverage of query (171 bits)
NUPO_BACSU / O05253 Guanosine import ATP-binding protein NupO; EC 7.6.2.- from Bacillus subtilis (strain 168) (see paper)
39% identity, 91% coverage of query (167 bits)
AO353_21385 m-Inositol ABC transporter, ATPase component (itaA) from Pseudomonas fluorescens FW300-N2E3
39% identity, 91% coverage of query (167 bits)
PS417_11890 Inositol transport system ATP-binding protein from Pseudomonas simiae WCS417
38% identity, 91% coverage of query (165 bits)
XylG / b3567 xylose ABC transporter ATP binding subunit (EC 7.5.2.13; EC 7.5.2.10) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
XylG / P37388 xylose ABC transporter ATP binding subunit (EC 7.5.2.13) from Escherichia coli (strain K12) (see 2 papers)
XYLG_ECOLI / P37388 Xylose import ATP-binding protein XylG; EC 7.5.2.10 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.2.4 / P37388 XylG aka B3567, component of Xylose porter from Escherichia coli (see 4 papers)
xylG / GB|AAC76591.1 D-xylose ABC transporter, ATP-binding protein; EC 3.6.3.17 from Escherichia coli K12 (see 2 papers)
38% identity, 91% coverage of query (164 bits)
TC 3.A.1.2.21 / B8H229 Inositol transport ATP-binding protein IatA, component of The myoinositol (high affinity)/ D-ribose (low affinity) transporter IatP/IatA/IbpA. The structure of IbpA with myoinositol bound has been solved from Caulobacter crescentus (strain NA1000 / CB15N)
39% identity, 91% coverage of query (163 bits)
YtfR / b4485 galactofuranose ABC transporter putative ATP binding subunit (EC 7.5.2.9) from Escherichia coli K-12 substr. MG1655 (see paper)
ytfR / Q6BEX0 galactofuranose ABC transporter putative ATP binding subunit (EC 7.5.2.9) from Escherichia coli (strain K12) (see paper)
36% identity, 91% coverage of query (162 bits)
MglA / b2149 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 6 papers)
MglA / P0AAG8 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.2.3 / P0AAG8 Galactose/methyl galactoside import ATP-binding protein MglA aka B2149, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli (see 7 papers)
36% identity, 91% coverage of query (157 bits)
MGLA_SALTY / P23924 Galactose/methyl galactoside import ATP-binding protein MglA; EC 7.5.2.11 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
35% identity, 91% coverage of query (156 bits)
TC 3.A.1.2.10 / O83341 Ribose/galactose ABC transporter, ATP-binding protein aka RbsA-2, component of The purine nucleoside permease (probably transports guanosine, adenosine, 2'-deoxyguanosine, inosine and xanthosine with decreasing affinity in this order) from Treponema pallidum (see paper)
35% identity, 90% coverage of query (155 bits)
eryE / Q2YIY4 putative erythritol ABC transporter ATP-binding protein from Brucella abortus (strain 2308) (see 3 papers)
37% identity, 89% coverage of query (155 bits)
Q73KK2 ABC-type D-galactose transporter (EC 7.5.2.11) from Treponema denticola (see paper)
34% identity, 93% coverage of query (154 bits)
Q6VMN4 ABC-type D-xylose transporter (EC 7.5.2.10) from Thermoanaerobacter ethanolicus (see paper)
34% identity, 91% coverage of query (152 bits)
AlsA / b4087 D-allose ABC transporter ATP binding subunit (EC 7.5.2.8) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
AlsA / P32721 D-allose ABC transporter ATP binding subunit (EC 7.5.2.8) from Escherichia coli (strain K12) (see 2 papers)
ALSA_ECOLI / P32721 D-allose import ATP-binding protein AlsA; EC 7.5.2.8 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.2.6 / P32721 AlsA aka B4087, component of D-allose porter from Escherichia coli (see 5 papers)
alsA / GB|AAC77048.1 D-allose import ATP-binding protein AlsA; EC 3.6.3.17 from Escherichia coli K12 (see 5 papers)
35% identity, 92% coverage of query (151 bits)
TC 3.A.1.2.26 / A6LW11 Xylose import ATP-binding protein XylG, component of Xylose transporter, XylFGH (XylF (R), 359 aas; XylG (C), 525 aas; XylH (M), 389 aas from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
37% identity, 91% coverage of query (150 bits)
TC 3.A.1.2.16 / Q1M4Q7 ATP binding component of erythritol ABC transporter, component of The erythritol uptake permease, EryEFG (Yost et al., 2006) (probably orthologous to 3.A.1.2.11) from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
36% identity, 85% coverage of query (150 bits)
TSGDD_HALVD / D4GPW3 Glucose import ATP-binding protein TsgD13; EC 7.5.2.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
34% identity, 91% coverage of query (148 bits)
TC 3.A.1.2.9 / Q7BSH4 RhaT, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii)
40% identity, 81% coverage of query (147 bits)
TC 3.A.1.2.11 / Q92WK2 EryE aka RB0337, component of The erythritol permease, EryEFG (Geddes et al., 2010) (probably orthologous to 3.A.1.2.16) from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
35% identity, 87% coverage of query (147 bits)
TC 3.A.1.2.12 / Q8DU37 RnsB, component of The (deoxy)ribonucleoside permease; probably takes up all deoxy- and ribonucleosides (cytidine, uridine, adenosine and toxic analogues, fluorocytidine and fluorouridine tested), but not ribose or nucleobases from Streptococcus mutans (see paper)
33% identity, 92% coverage of query (140 bits)
AraG / b1900 arabinose ABC transporter ATP binding subunit (EC 7.5.2.13; EC 7.5.2.12) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
AraG / P0AAF3 arabinose ABC transporter ATP binding subunit (EC 7.5.2.13) from Escherichia coli (strain K12) (see paper)
ARAG_ECOLI / P0AAF3 Arabinose import ATP-binding protein AraG; EC 7.5.2.12 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.2.2 / P0AAF3 Arabinose import ATP-binding protein AraG aka B1900, component of Arabinose porter from Escherichia coli (see 6 papers)
araG / RF|NP_416413.1 L-arabinose ABC transporter, ATP-binding protein AraG; EC 3.6.3.17 from Escherichia coli K12 (see paper)
34% identity, 95% coverage of query (139 bits)
PS417_12065 xylitol ABC transporter, ATPase component from Pseudomonas simiae WCS417
33% identity, 91% coverage of query (137 bits)
BPHYT_RS16930 D-galactose ABC transporter, ATPase component from Burkholderia phytofirmans PsJN
33% identity, 89% coverage of query (136 bits)
Pf1N1B4_410 ABC transporter for D-galactose/L-arabinose, ATPase component from Pseudomonas fluorescens FW300-N1B4
33% identity, 95% coverage of query (134 bits)
BPHYT_RS34245 ABC transporter for L-rhamnose/L-fucose/xylitol, ATPase component from Burkholderia phytofirmans PsJN
31% identity, 94% coverage of query (133 bits)
NUPA_LACLM / A2RKA7 Nucleoside import ATP-binding protein NupA; EC 7.6.2.- from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
TC 3.A.1.2.17 / A2RKA7 Purine/cytidine ABC transporter ATP-binding protein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al., 2010) (Most similar to 3.A.1.2.12). NupA is 506aas with two ABC (C) domains. NupB has 8 predicted TMSs, NupC has 9 or 10 predicted TMSs in a 4 + 1 (or 2) + 4 arrangement from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
33% identity, 91% coverage of query (132 bits)
YphE / b2547 putative ABC transporter ATP-binding protein YphE from Escherichia coli K-12 substr. MG1655 (see 4 papers)
31% identity, 93% coverage of query (130 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
30% identity, 92% coverage of query (107 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
30% identity, 92% coverage of query (107 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
30% identity, 90% coverage of query (102 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
30% identity, 90% coverage of query (102 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
30% identity, 90% coverage of query (101 bits)
Build an alignment for GFF3641 and 44 homologs with ≥ 30% identity
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6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
26% identity, 92% coverage of query (100 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
29% identity, 90% coverage of query (100 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
30% identity, 90% coverage of query (99.8 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
30% identity, 90% coverage of query (99.8 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
32% identity, 82% coverage of query (99.0 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 88% coverage of query (98.2 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
28% identity, 88% coverage of query (98.2 bits)
2olkA Abc protein artp in complex with adp-beta-s
28% identity, 88% coverage of query (98.2 bits)
2oljA Abc protein artp in complex with adp/mg2+
28% identity, 88% coverage of query (98.2 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
31% identity, 82% coverage of query (98.2 bits)
MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
29% identity, 85% coverage of query (97.8 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
32% identity, 82% coverage of query (97.8 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
32% identity, 82% coverage of query (97.8 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
32% identity, 82% coverage of query (97.8 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
31% identity, 85% coverage of query (97.1 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
27% identity, 84% coverage of query (96.7 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
29% identity, 84% coverage of query (96.7 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
31% identity, 89% coverage of query (94.7 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
29% identity, 80% coverage of query (92.8 bits)
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
24% identity, 92% coverage of query (92.8 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
28% identity, 84% coverage of query (92.8 bits)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
28% identity, 84% coverage of query (92.8 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
28% identity, 84% coverage of query (92.4 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
31% identity, 79% coverage of query (91.7 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
28% identity, 84% coverage of query (90.9 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
28% identity, 84% coverage of query (90.9 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
28% identity, 87% coverage of query (90.1 bits)
FhuC / b0151 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FhuC / P07821 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see paper)
FHUC_ECOLI / P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.3 / P07821 FhuC aka B0151, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 6 papers)
fhuC / GB|BAB96727.2 ferrichrome transport ATP-binding protein FhuC; EC 3.6.3.34 from Escherichia coli K12 (see 8 papers)
27% identity, 89% coverage of query (89.0 bits)
1g291 / Q9YGA6 Malk (see paper)
30% identity, 87% coverage of query (89.0 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
26% identity, 87% coverage of query (89.0 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
31% identity, 80% coverage of query (88.6 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
30% identity, 85% coverage of query (88.6 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
27% identity, 87% coverage of query (88.6 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
29% identity, 87% coverage of query (87.8 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
29% identity, 87% coverage of query (87.8 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 87% coverage of query (87.8 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
29% identity, 79% coverage of query (87.8 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
28% identity, 83% coverage of query (87.0 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
27% identity, 86% coverage of query (86.7 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
27% identity, 87% coverage of query (86.3 bits)
8hprD Lpqy-sugabc in state 4
30% identity, 80% coverage of query (86.3 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
30% identity, 80% coverage of query (86.3 bits)
8hprC Lpqy-sugabc in state 4
30% identity, 80% coverage of query (86.3 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
27% identity, 88% coverage of query (85.9 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
26% identity, 88% coverage of query (85.9 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
25% identity, 88% coverage of query (84.7 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
28% identity, 79% coverage of query (84.3 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 79% coverage of query (84.3 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
28% identity, 79% coverage of query (84.3 bits)
8t1pD Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
30% identity, 88% coverage of query (84.0 bits)
7lkpA Structure of atp-free human abca4
28% identity, 79% coverage of query (84.0 bits)
7w78A / Q6NEF2 Heme exporter hrtba in complex with mg-amppnp (see paper)
28% identity, 86% coverage of query (83.6 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
28% identity, 84% coverage of query (83.6 bits)
8fmvD Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to substrate and atp: bmrcd_if-2ht/atp
30% identity, 88% coverage of query (83.2 bits)
7w79A Heme exporter hrtba in complex with mn-amppnp
28% identity, 84% coverage of query (83.2 bits)
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Lawrence Berkeley National Laboratory