Searching for up to 100 curated homologs for GFF3785 FitnessBrowser__psRCH2:GFF3785 (234 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
47% identity, 100% coverage of query (191 bits)
LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
46% identity, 91% coverage of query (181 bits)
TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
42% identity, 89% coverage of query (178 bits)
TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
42% identity, 99% coverage of query (172 bits)
TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
44% identity, 89% coverage of query (169 bits)
TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
44% identity, 90% coverage of query (166 bits)
TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
42% identity, 98% coverage of query (164 bits)
braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
43% identity, 90% coverage of query (164 bits)
HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
43% identity, 90% coverage of query (163 bits)
AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
42% identity, 89% coverage of query (162 bits)
Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
42% identity, 88% coverage of query (160 bits)
Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
43% identity, 89% coverage of query (160 bits)
TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
38% identity, 89% coverage of query (152 bits)
TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
36% identity, 98% coverage of query (149 bits)
E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
35% identity, 92% coverage of query (140 bits)
lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
36% identity, 90% coverage of query (138 bits)
TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
39% identity, 88% coverage of query (133 bits)
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
35% identity, 90% coverage of query (132 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 89% coverage of query (131 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
34% identity, 93% coverage of query (126 bits)
YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
34% identity, 93% coverage of query (126 bits)
A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
33% identity, 89% coverage of query (124 bits)
TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
39% identity, 88% coverage of query (124 bits)
TC 3.A.1.3.7 / Q52666 BztD, component of Glutamate/glutamine/aspartate/asparagine porter from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
35% identity, 91% coverage of query (123 bits)
lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
32% identity, 93% coverage of query (123 bits)
SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
33% identity, 95% coverage of query (122 bits)
LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
35% identity, 90% coverage of query (122 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
35% identity, 90% coverage of query (122 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
35% identity, 90% coverage of query (122 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
35% identity, 90% coverage of query (122 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
35% identity, 90% coverage of query (122 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
35% identity, 90% coverage of query (122 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
35% identity, 90% coverage of query (122 bits)
TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
34% identity, 91% coverage of query (121 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
35% identity, 90% coverage of query (120 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 93% coverage of query (108 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 94% coverage of query (98.6 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
30% identity, 94% coverage of query (98.6 bits)
2olkA Abc protein artp in complex with adp-beta-s
30% identity, 94% coverage of query (98.6 bits)
2oljA Abc protein artp in complex with adp/mg2+
30% identity, 94% coverage of query (98.6 bits)
MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
30% identity, 90% coverage of query (96.3 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
32% identity, 90% coverage of query (95.1 bits)
Build an alignment for GFF3785 and 42 homologs with ≥ 30% identity
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5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
29% identity, 90% coverage of query (94.4 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
29% identity, 89% coverage of query (94.4 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
33% identity, 83% coverage of query (92.0 bits)
7roqA / O95477 Alternative structure of human abca1
33% identity, 82% coverage of query (92.0 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
28% identity, 94% coverage of query (91.7 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 91% coverage of query (91.3 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
29% identity, 97% coverage of query (90.9 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
31% identity, 89% coverage of query (90.5 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
30% identity, 87% coverage of query (90.5 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
31% identity, 89% coverage of query (90.1 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
25% identity, 91% coverage of query (89.7 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
29% identity, 92% coverage of query (89.4 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
29% identity, 87% coverage of query (89.4 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
29% identity, 87% coverage of query (89.4 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 87% coverage of query (89.4 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
34% identity, 85% coverage of query (88.2 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
32% identity, 80% coverage of query (88.2 bits)
7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8)
34% identity, 94% coverage of query (85.9 bits)
7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4)
34% identity, 94% coverage of query (85.9 bits)
7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
34% identity, 94% coverage of query (85.9 bits)
8ipsA / P23886 Cryo-em structure of heme transporter cyddc from escherichia coli in the inward facing heme loading state (see paper)
34% identity, 94% coverage of query (85.5 bits)
7zdbC If(heme/bound) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
34% identity, 90% coverage of query (85.5 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
31% identity, 88% coverage of query (85.1 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
31% identity, 88% coverage of query (85.1 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
31% identity, 88% coverage of query (85.1 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
31% identity, 88% coverage of query (85.1 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
31% identity, 88% coverage of query (85.1 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
31% identity, 88% coverage of query (85.1 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
31% identity, 88% coverage of query (85.1 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
31% identity, 88% coverage of query (84.7 bits)
ABC3_SCHPO / Q9P5N0 Vacuolar heme ABC transmembrane exporter abc3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
TC 3.A.1.208.28 / Q9P5N0 Vacuolar iron transporter, Abc3(+) of 1465 aas from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
abc3 ABC transporter Abc3, unknown specificity from Schizosaccharomyces pombe (see paper)
31% identity, 94% coverage of query (84.7 bits)
7zdtC Occ(apo/return) conformation of cyddc mutant (e500q.C) in atp(cydc) bound state (dataset-18)
34% identity, 94% coverage of query (84.3 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
29% identity, 85% coverage of query (84.3 bits)
FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
28% identity, 86% coverage of query (84.0 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
32% identity, 85% coverage of query (84.0 bits)
8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
28% identity, 86% coverage of query (84.0 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
30% identity, 88% coverage of query (83.6 bits)
8tzjA / A0A085R4L6 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
30% identity, 79% coverage of query (83.6 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
30% identity, 82% coverage of query (83.2 bits)
8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
28% identity, 85% coverage of query (82.8 bits)
CFTR / P13569 cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) from Homo sapiens (see 23 papers)
CFTR_HUMAN / P13569 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Homo sapiens (Human) (see 120 papers)
P13569 adenylate kinase (EC 2.7.4.3); channel-conductance-controlling ATPase (EC 5.6.1.6) from Homo sapiens (see 17 papers)
TC 3.A.1.202.1 / P13569 Cystic fibrosis transmembrane conductance regulator (CFTR) (also called ABCC7); cyclic AMP-dependent chloride channel; also catalyzes nucleotide (ATP-ADP)-dependent glutathione and glutathione-conjugate flux (Kogan et al., 2003) (may also activate inward rectifying K+ channels). The underlying mechanism by which ATP hydrolysis controls channel opening is described by Gadsby et al., 2006. The most common cause of cystic fibrosis (CF) is defective folding of a cystic fibrosis transmembrane conductance regulator (CFTR) mutant lacking Phe508 (DeltaF508)(Riordan, 2008). The DeltaF508 protein appears to be trapped in a prefolded state with incomplete packing of the transmembrane segments, a defect that can be repaired by direct interaction with correctors such as corr-4a, VRT-325, and VRT-532 (Wang et al., 2007). CFTR interacts directly with MRP4 (3.A.1.208.7) to control Cl- secretion (Li et al., 2007). It has intrinsic adenylate kinase activity that may be of functional importance (Randak and Welsh, 2007). The intact CFTR protein mediates ATPase rather than adenylate kinase activity (Ramjeesingh et al., 2008). Regulated by Na+/H+ exchange regulatory cofactors (NHERF; O14745; TC #8.A.24.1.1) (Seidler et al., 2009). Regulated by protein kinase A and C phosphorylation (Csanády et al., 2010). It is also activated by membrane stretch induced by negative pressures (Zhang et al., 2010). TMS6 plays roles in gating and permeation (Bai et al., 2010; 2011). The 3-D structure revealed the probable location of the channel gate (Rosenberg et al., 2011). Conformational changes opening the CFTR chloride channel pore, coupled to ATP-dependent gating, have been studied (Wang and Linsdell, 2012). Alternating access to the transmembrane domain of CFTR has been demonstrated from Homo sapiens (Human) (see 71 papers)
CFTR / RF|NP_000483.3 cystic fibrosis transmembrane conductance regulator from Homo sapiens (see paper)
31% identity, 97% coverage of query (82.4 bits)
AB25B_ARATH / Q9LVM1 ABC transporter B family member 25, mitochondrial; ABC transporter ABCB.25; AtABCB25; ABC transporter of the mitochondrion 3; AtATM3; Iron-sulfur clusters transporter ATM3; Protein STARIK 1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.210.8 / Q9LVM1 Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively from Arabidopsis thaliana (Mouse-ear cress) (see 11 papers)
GB|AAN13224.1 putative ABC transporter protein from Arabidopsis thaliana (see paper)
30% identity, 89% coverage of query (81.6 bits)
7n59A / Q9LVM1 Structure of atatm3 in the inward-facing conformation with gssg bound (see paper)
30% identity, 88% coverage of query (81.3 bits)
7n5aA Structure of atatm3 in the closed conformation
30% identity, 88% coverage of query (81.3 bits)
CFTR_DANRE / Q1LX78 Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 6 papers)
Q1LX78 channel-conductance-controlling ATPase (EC 5.6.1.6) from Danio rerio (see paper)
29% identity, 97% coverage of query (80.9 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
31% identity, 83% coverage of query (80.9 bits)
6msmA / P13569 Phosphorylated, atp-bound human cystic fibrosis transmembrane conductance regulator (cftr) (see paper)
30% identity, 97% coverage of query (80.9 bits)
6o2pA Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (cftr)
30% identity, 97% coverage of query (80.9 bits)
6o1vA Complex of human cystic fibrosis transmembrane conductance regulator (cftr) and glpg1837
30% identity, 97% coverage of query (80.9 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
29% identity, 84% coverage of query (80.9 bits)
8ubrA Cystic fibrosis transmembrane conductance regulator
30% identity, 97% coverage of query (80.9 bits)
7svdA The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with atp/mg and lumacaftor (vx-809)
30% identity, 97% coverage of query (80.9 bits)
7sv7A The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with atp/mg and tezacaftor (vx-661)
30% identity, 97% coverage of query (80.9 bits)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
28% identity, 89% coverage of query (80.1 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
28% identity, 89% coverage of query (80.1 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
27% identity, 90% coverage of query (79.7 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
27% identity, 90% coverage of query (79.7 bits)
3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
32% identity, 92% coverage of query (79.7 bits)
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Lawrence Berkeley National Laboratory