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Searching for up to 100 curated homologs for GFF3795 FitnessBrowser__psRCH2:GFF3795 (217 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

Removed hits that are identical to the query, leaving 14

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HIS9_PSEAE / Q9I6F6 Histidinol-phosphatase; Hol-Pase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    72% identity, 100% coverage of query (332 bits)

HP15_461 Histidinol-phosphatase (EC:3.1.3.15) from Marinobacter adhaerens HP15
    53% identity, 100% coverage of query (247 bits)

BPHYT_RS03625 Histidinol-phosphatase (EC:3.1.3.15) from Burkholderia phytofirmans PsJN
    47% identity, 99% coverage of query (209 bits)

HIS9_NEIM8 / P0DV34 Histidinol-phosphatase; Hol-Pase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Neisseria meningitidis serogroup C (strain 8013) (see paper)
    44% identity, 100% coverage of query (204 bits)

SERB1_MYCTU / P9WGJ3 Phosphoserine phosphatase SerB1; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    31% identity, 99% coverage of query (95.5 bits)

Build an alignment

Build an alignment for GFF3795 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SERB2_MYCTU / O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
O53289 phosphoserine phosphatase (EC 3.1.3.3) from Mycobacterium tuberculosis (see 2 papers)
    24% identity, 94% coverage of query (50.1 bits)

SERB_POLSJ / Q12A06 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
    26% identity, 94% coverage of query (50.1 bits)

1l7nA Transition state analogue of phosphoserine phosphatase (aluminum fluoride complex)
    22% identity, 94% coverage of query (45.8 bits)

1f5sA / Q58989 Crystal structure of phosphoserine phosphatase from methanococcus jannaschii (see paper)
    22% identity, 94% coverage of query (45.8 bits)

SERB_METJA / Q58989 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58989 phosphoserine phosphatase (EC 3.1.3.3) from Methanocaldococcus jannaschii (see 4 papers)
    22% identity, 94% coverage of query (45.8 bits)

5jlpA Crystal structure of mycobacterium avium serb2 in complex with serine at act domain
    24% identity, 94% coverage of query (43.1 bits)

8a21A Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with phenylimidazole
    24% identity, 94% coverage of query (43.1 bits)

8a1zA / A0QJI1 Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with 1-(2,4-dichlorophenyl)-3-hydroxyurea (see paper)
    24% identity, 94% coverage of query (43.1 bits)

SERB_MYCA1 / A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium avium (strain 104) (see paper)
    24% identity, 94% coverage of query (42.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory