Sites on a Tree

 

Searching for up to 100 curated homologs for GFF38 FitnessBrowser__Marino:GFF38 (329 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
    30% identity, 95% coverage of query (119 bits)

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    30% identity, 95% coverage of query (119 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    30% identity, 95% coverage of query (119 bits)

6iymA / K0A9N9 Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
    32% identity, 75% coverage of query (112 bits)

lra6 / Q1NEI7 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
    33% identity, 72% coverage of query (111 bits)

K0A9N9 fumarylacetoacetase (EC 3.7.1.2) from Exiguobacterium antarcticum (see paper)
    31% identity, 75% coverage of query (109 bits)

Build an alignment

Build an alignment for GFF38 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
    28% identity, 99% coverage of query (108 bits)

6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
    28% identity, 74% coverage of query (82.8 bits)

3bqbX / Q97UA0 Hexagonal kristal form of 2-keto-3-deoxyarabinonate dehydratase (see paper)
    25% identity, 75% coverage of query (67.0 bits)

kdaD / Q97UA0 2-keto-3-deoxy-D-arabinonate dehydratase subunit (EC 4.2.1.141) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see 2 papers)
KDAD_SACS2 / Q97UA0 2-dehydro-3-deoxy-D-arabinonate dehydratase; 2-keto-3-deoxy-D-arabinonate dehydratase; KdaD; EC 4.2.1.141 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97UA0 2-dehydro-3-deoxy-D-arabinonate dehydratase (EC 4.2.1.141) from Saccharolobus solfataricus (see 2 papers)
    25% identity, 75% coverage of query (67.0 bits)

2q1cX 2-keto-3-deoxy-d-arabinonate dehydratase complexed with calcium and 2- oxobutyrate
    25% identity, 75% coverage of query (67.0 bits)

2q1aX 2-keto-3-deoxy-d-arabinonate dehydratase complexed with magnesium and 2-oxobutyrate
    25% identity, 75% coverage of query (67.0 bits)

GI|2832727 fumarylacetoacetate hydrolase; EC 3.7.1.2 from Emericella nidulans (see 2 papers)
fahA / CAA05043.1 fumarylacetoacetate hydrolase from Aspergillus nidulans (see paper)
    24% identity, 76% coverage of query (66.6 bits)

FAAA_EMENI / Q00770 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    24% identity, 76% coverage of query (65.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory