Searching for up to 100 curated homologs for GFF3833 PGA1_262p02370 putative histidine transport system permease protein HisQ (250 a.a.)
Found high-coverage hits (≥70%) to 42 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
AO353_03050 ABC transporter for L-Arginine and L-Citrulline, permease component 2 from Pseudomonas fluorescens FW300-N2E3
44% identity, 86% coverage of query (169 bits)
PS417_21740 ABC transporter for L-Arginine, permease component 1 from Pseudomonas simiae WCS417
43% identity, 86% coverage of query (167 bits)
Pf1N1B4_3432 ABC transporter for L-Arginine and L-Citrulline, permease component 1 from Pseudomonas fluorescens FW300-N1B4
42% identity, 86% coverage of query (166 bits)
AO356_18705 L-Arginine ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N2C3
42% identity, 86% coverage of query (165 bits)
Pf6N2E2_5661 L-Arginine ABC transporter, permease protein AotQ from Pseudomonas fluorescens FW300-N2E2
42% identity, 86% coverage of query (164 bits)
BPHYT_RS24005 L-histidine ABC transporter, permease component 1 from Burkholderia phytofirmans PsJN
41% identity, 90% coverage of query (164 bits)
TC 3.A.1.3.6 / P35118 NocQ aka ATU6026 aka AGR_PTI_66, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
42% identity, 92% coverage of query (162 bits)
TC 3.A.1.3.5 / P0A4N5 Octopine transport system permease protein occQ, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
37% identity, 92% coverage of query (154 bits)
SMc00139 L-lysine ABC transporter, permease component 1 from Sinorhizobium meliloti 1021
39% identity, 92% coverage of query (153 bits)
hisQ / b2308 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisQ (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
HISQ_ECOLI / P52094 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P52094 Histidine transport system permease protein HisQ, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
39% identity, 86% coverage of query (147 bits)
HISQ_SALTY / P0A2I9 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I9 Histidine transport system permease protein HisQ aka STM2353, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
40% identity, 86% coverage of query (146 bits)
Pf6N2E2_2959 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2E2
41% identity, 72% coverage of query (136 bits)
AO356_05500 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
41% identity, 72% coverage of query (136 bits)
TC 3.A.1.3.11 / O50182 AotQ, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa (see paper)
aotQ / GI|2668596 arginine/ornithine transport protein from Pseudomonas aeruginosa (see paper)
39% identity, 79% coverage of query (130 bits)
TC 3.A.1.3.23 / Q9HU30 Probable permease of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
37% identity, 89% coverage of query (127 bits)
PP_3594 L-lysine and D-lysine ABC transporter, permease component 1 from Pseudomonas putida KT2440
31% identity, 92% coverage of query (112 bits)
4ymtC / Q8RCC3 Crystal structure of an amino acid abc transporter complex with arginines (see paper)
33% identity, 88% coverage of query (110 bits)
4ymwC Crystal structure of an amino acid abc transporter with histidines
33% identity, 87% coverage of query (109 bits)
TC 3.A.1.3.12 / P73544 BgtB aka GLNH aka SLL1270, component of Arginine/lysine/histidine/glutamine porter (see paper)
33% identity, 84% coverage of query (97.1 bits)
Build an alignment for GFF3833 and 19 homologs with ≥ 30% identity
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TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
29% identity, 89% coverage of query (94.7 bits)
TcyL / b1918 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
tcyL / P0AFT2 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 3 papers)
TCYL_ECOLI / P0AFT2 L-cystine transport system permease protein TcyL from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P0AFT2 Inner membrane amino-acid ABC transporter permease protein YECS CysY aka B1918, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 4 papers)
32% identity, 93% coverage of query (94.7 bits)
GlnP / b0810 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnP / P0AEQ6 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.3.2 / P0AEQ6 Glutamine transport system permease protein GlnP aka B0810, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
29% identity, 84% coverage of query (94.7 bits)
TC 3.A.1.3.6 / P35113 NocM aka ATU6025 aka AGR_PTI_65, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
30% identity, 89% coverage of query (93.2 bits)
Ac3H11_2554 ABC transporter for L-Histidine, permease component 1 from Acidovorax sp. GW101-3H11
31% identity, 88% coverage of query (90.5 bits)
AO356_00470 ABC transporter for D-Glucosamine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
Pf6N2E2_2051 ABC transporter for D-Glucosamine Hydrochloride, permease component 1 from Pseudomonas fluorescens FW300-N2E2
30% identity, 84% coverage of query (86.7 bits)
AO353_21720 ABC transporter for D-glucosamine, permease component 2 from Pseudomonas fluorescens FW300-N2E3
29% identity, 84% coverage of query (85.5 bits)
HisM / b2307 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
HISM_ECOLI / P0AEU3 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU3 Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
29% identity, 90% coverage of query (85.5 bits)
HISM_SALTY / P0A2I7 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
30% identity, 86% coverage of query (84.0 bits)
YXEN_BACSU / P54953 Probable amino-acid permease protein YxeN from Bacillus subtilis (strain 168) (see paper)
29% identity, 70% coverage of query (83.6 bits)
AO353_21715 ABC transporter for D-glucosamine, permease component 1 from Pseudomonas fluorescens FW300-N2E3
31% identity, 78% coverage of query (82.4 bits)
AO356_00475 ABC transporter for D-Glucosamine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
30% identity, 78% coverage of query (82.4 bits)
Pf6N2E2_2052 ABC transporter for D-Glucosamine Hydrochloride, permease component 2 from Pseudomonas fluorescens FW300-N2E2
30% identity, 78% coverage of query (81.6 bits)
BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
28% identity, 85% coverage of query (77.8 bits)
ARTQ_BACSU / P54536 Arginine transport system permease protein ArtQ from Bacillus subtilis (strain 168) (see paper)
27% identity, 86% coverage of query (76.6 bits)
TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
29% identity, 86% coverage of query (76.3 bits)
ARGU_CORGL / Q8NQU3 Arginine transport system permease protein ArgU from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
25% identity, 87% coverage of query (75.5 bits)
TCYB_BACSU / P42200 L-cystine transport system permease protein TcyB from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.3.14 / P42200 TcyB (YckJ), component of Uptake system for L-cystine from Bacillus subtilis (see 4 papers)
26% identity, 82% coverage of query (75.1 bits)
SMc00138 L-lysine ABC transporter, permease component 2 from Sinorhizobium meliloti 1021
28% identity, 85% coverage of query (75.1 bits)
PS417_21735 ABC transporter for L-Arginine, permease component 2 from Pseudomonas simiae WCS417
30% identity, 70% coverage of query (74.7 bits)
TCYL_BACSU / O34315 L-cystine transport system permease protein TcyL from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34315 TcyL (YtmL), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
26% identity, 78% coverage of query (73.9 bits)
AO356_18710 L-Arginine ABC transporter, permease component 1 from Pseudomonas fluorescens FW300-N2C3
30% identity, 70% coverage of query (73.6 bits)
AO353_03045 ABC transporter for L-Arginine and L-Citrulline, permease component 1 from Pseudomonas fluorescens FW300-N2E3
29% identity, 70% coverage of query (73.2 bits)
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Lawrence Berkeley National Laboratory