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Searching for up to 100 curated homologs for GFF39 FitnessBrowser__psRCH2:GFF39 (554 a.a.)

Found high-coverage hits (≥70%) to 48 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
    63% identity, 100% coverage of query (706 bits)

pgmA / I6Y2G3 phosphoglucomutase (EC 5.4.2.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
I6Y2G3 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Mycobacterium tuberculosis (see paper)
    64% identity, 99% coverage of query (676 bits)

A0A0H3NJ17 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Q8ZQW9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    61% identity, 100% coverage of query (657 bits)

2fuvA / Q8ZQW9 Phosphoglucomutase from salmonella typhimurium.
    60% identity, 99% coverage of query (654 bits)

Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
    61% identity, 100% coverage of query (647 bits)

Build an alignment

Build an alignment for GFF39 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PGM1 / P33401 phosphoglucomutase-1 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
PGM1_YEAST / P33401 Phosphoglucomutase 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
    28% identity, 92% coverage of query (107 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    28% identity, 75% coverage of query (100 bits)

6snqA Crystal structures of human pgm1 isoform 2
    28% identity, 75% coverage of query (100 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    28% identity, 75% coverage of query (99.4 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    28% identity, 75% coverage of query (99.4 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    28% identity, 75% coverage of query (99.4 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    28% identity, 75% coverage of query (99.4 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    28% identity, 75% coverage of query (97.4 bits)

PGM1_RAT / P38652 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Rattus norvegicus (Rat) (see paper)
    28% identity, 75% coverage of query (95.1 bits)

PGM5_HUMAN / Q15124 Phosphoglucomutase-like protein 5; Aciculin; Phosphoglucomutase-related protein; PGM-RP from Homo sapiens (Human) (see 2 papers)
    27% identity, 70% coverage of query (94.0 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    27% identity, 75% coverage of query (94.0 bits)

PGM5_MOUSE / Q8BZF8 Phosphoglucomutase-like protein 5 from Mus musculus (Mouse) (see paper)
    27% identity, 70% coverage of query (92.0 bits)

PGM2 / P37012 phosphoglucomutase-2 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
PGM2_YEAST / P37012 Phosphoglucomutase 2; PGM 2; D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase; Glucose phosphomutase 2; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
    25% identity, 94% coverage of query (92.0 bits)

6y8yA / A0A6P3VN15 Structure of baltic herring (clupea harengus) phosphoglucomutase 5 (pgm5) with bound glucose-1-phosphate (see paper)
    26% identity, 78% coverage of query (90.9 bits)

PGM5_RAT / D3ZVR9 Phosphoglucomutase-like protein 5 from Rattus norvegicus (Rat) (see paper)
    25% identity, 86% coverage of query (89.7 bits)

PGM_ENTH1 / O15820 Phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
    26% identity, 77% coverage of query (89.7 bits)

7pjcB / A0A1D8PSA9 The structure of candida albicans phosphoglucomutase with isothiazolone modification on cys359
    26% identity, 91% coverage of query (88.2 bits)

PGM_DROME / Q9VUY9 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Drosophila melanogaster (Fruit fly) (see paper)
    26% identity, 85% coverage of query (88.2 bits)

A0A2H5BEG8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Ganoderma lucidum (see paper)
    27% identity, 70% coverage of query (87.8 bits)

Q4QCF1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Leishmania major (see paper)
    27% identity, 71% coverage of query (82.8 bits)

Q9SGC1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    26% identity, 78% coverage of query (79.7 bits)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    24% identity, 92% coverage of query (79.3 bits)

A8N8Z1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Coprinopsis cinerea (see paper)
    27% identity, 75% coverage of query (79.0 bits)

Q670S5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Trypanosoma cruzi (see paper)
    26% identity, 71% coverage of query (79.0 bits)

PGM / Q9SCY0 phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see 2 papers)
PGMP_ARATH / Q9SCY0 Phosphoglucomutase, chloroplastic; PGM; Glucose phosphomutase; Protein REDUCED GRAVITROPIC 2; EC 5.4.2.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SCY0 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    24% identity, 94% coverage of query (75.9 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    25% identity, 88% coverage of query (73.9 bits)

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    23% identity, 88% coverage of query (73.2 bits)

AAV49510.1 phosphoglucomutase from Acidithiobacillus ferrooxidans (see paper)
    28% identity, 79% coverage of query (73.2 bits)

O49299 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Arabidopsis thaliana (see paper)
    24% identity, 78% coverage of query (68.9 bits)

P74027 glucose-1,6-bisphosphate synthase from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    26% identity, 73% coverage of query (68.6 bits)

4il8A / P26276 Crystal structure of an h329a mutant of p. Aeruginosa pmm/pgm (see paper)
    23% identity, 82% coverage of query (59.7 bits)

3uw2A / Q2SYG4 X-ray crystal structure of phosphoglucomutase/phosphomannomutase family protein (bth_i1489)from burkholderia thailandensis (see paper)
    25% identity, 71% coverage of query (59.3 bits)

1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    22% identity, 82% coverage of query (59.3 bits)

algC / P26276 phosphomannomutase (EC 5.4.2.2; EC 5.4.2.8) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
ALGC_PSEAE / P26276 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 12 papers)
    22% identity, 82% coverage of query (59.3 bits)

Q02E40 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain UCBPP-PA14)
    22% identity, 82% coverage of query (59.3 bits)

2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate
    22% identity, 82% coverage of query (58.9 bits)

2h4lX Complex of pmm/pgm with ribose 1-phosphate
    22% identity, 82% coverage of query (58.9 bits)

2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound
    22% identity, 82% coverage of query (58.9 bits)

1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    22% identity, 82% coverage of query (58.9 bits)

1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    22% identity, 82% coverage of query (58.9 bits)

1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    22% identity, 82% coverage of query (58.9 bits)

1k2yX Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa
    22% identity, 82% coverage of query (58.2 bits)

PGM2 / Q96G03 phosphoglucomutase-2 (EC 5.4.2.2; EC 5.4.2.7) from Homo sapiens (see 2 papers)
PGM2_HUMAN / Q96G03 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-2; EC 5.4.2.7; EC 5.4.2.2 from Homo sapiens (Human) (see 2 papers)
    24% identity, 71% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory