Searching for up to 100 curated homologs for GFF3963 FitnessBrowser__Marino:GFF3963 (310 a.a.)
Found high-coverage hits (≥70%) to 62 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
74% identity, 100% coverage of query (481 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
52% identity, 95% coverage of query (302 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
49% identity, 100% coverage of query (297 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
49% identity, 100% coverage of query (296 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
49% identity, 100% coverage of query (296 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
49% identity, 100% coverage of query (295 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
47% identity, 99% coverage of query (277 bits)
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
48% identity, 93% coverage of query (266 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
46% identity, 70% coverage of query (190 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
46% identity, 70% coverage of query (187 bits)
PROV_SALTY / P17328 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
45% identity, 73% coverage of query (187 bits)
ProU / b2677 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
proV / P14175 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli (strain K12) (see 6 papers)
PROV_ECOLI / P14175 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.12.1 / P14175 ProV aka B2677, component of Glycine betaine/proline porter, ProU or ProVWX (also transports proline betaine, carnitine, dimethyl proline, homobetaine, γ-butyrobetaine and choline with low affinity) from Escherichia coli (see 6 papers)
proV / GB|AAC75724.1 glycine betaine/l-proline transport atp-binding protein prov from Escherichia coli K12 (see 6 papers)
45% identity, 73% coverage of query (187 bits)
TCYN_BACSU / O34900 L-cystine import ATP-binding protein TcyN; EC 7.4.2.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34900 TcyN (YtmN), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
45% identity, 70% coverage of query (180 bits)
GBUA_LISM4 / Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
41% identity, 74% coverage of query (179 bits)
TC 3.A.1.3.14 / P39456 TcyC (YckI), component of Uptake system for L-cystine from Bacillus subtilis (see 7 papers)
43% identity, 70% coverage of query (176 bits)
TcyN / b1917 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
tcyN / P37774 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 7 papers)
TCYN_ECOLI / P37774 L-cystine transport system ATP-binding protein TcyN; EC 7.4.2.12 from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P37774 YECC aka CysZ aka B1917, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 5 papers)
44% identity, 70% coverage of query (175 bits)
YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
43% identity, 70% coverage of query (174 bits)
AO356_09610 ABC transporter for L-Histidine, ATPase component from Pseudomonas fluorescens FW300-N2C3
45% identity, 70% coverage of query (174 bits)
TC 3.A.1.12.9 / Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see 2 papers)
43% identity, 72% coverage of query (172 bits)
TC 3.A.1.3.5 / P0A2V2 Octopine permease ATP-binding protein P aka occP, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
41% identity, 70% coverage of query (172 bits)
TC 3.A.1.12.5 / Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see paper)
40% identity, 72% coverage of query (172 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
38% identity, 70% coverage of query (147 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
37% identity, 77% coverage of query (145 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
36% identity, 70% coverage of query (139 bits)
1g291 / Q9YGA6 Malk (see paper)
35% identity, 70% coverage of query (137 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
36% identity, 71% coverage of query (136 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
36% identity, 71% coverage of query (136 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
35% identity, 71% coverage of query (132 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
35% identity, 70% coverage of query (129 bits)
8hprD Lpqy-sugabc in state 4
34% identity, 90% coverage of query (126 bits)
8hprC Lpqy-sugabc in state 4
34% identity, 90% coverage of query (126 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
34% identity, 90% coverage of query (126 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
35% identity, 71% coverage of query (126 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
35% identity, 71% coverage of query (126 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
35% identity, 71% coverage of query (125 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
32% identity, 89% coverage of query (123 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
35% identity, 71% coverage of query (122 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
34% identity, 71% coverage of query (114 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
30% identity, 70% coverage of query (111 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
30% identity, 70% coverage of query (111 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
30% identity, 70% coverage of query (111 bits)
SapD / b1291 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
SapD / P0AAH4 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli (strain K12) (see 5 papers)
SAPD_ECOLI / P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see 2 papers)
32% identity, 70% coverage of query (110 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
33% identity, 78% coverage of query (108 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
34% identity, 78% coverage of query (107 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
34% identity, 78% coverage of query (107 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
34% identity, 78% coverage of query (107 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
32% identity, 70% coverage of query (106 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
32% identity, 70% coverage of query (106 bits)
BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
33% identity, 72% coverage of query (105 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
32% identity, 70% coverage of query (105 bits)
7ow8A / O06967 Cryoem structure of the abc transporter bmra e504a mutant in complex with atp-mg (see paper)
33% identity, 72% coverage of query (103 bits)
7bg4A Multidrug resistance transporter bmra mutant e504a bound with atp, mg, and rhodamine 6g solved by cryo-em
33% identity, 72% coverage of query (103 bits)
4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
31% identity, 74% coverage of query (94.4 bits)
4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
30% identity, 74% coverage of query (92.0 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
30% identity, 76% coverage of query (91.3 bits)
Build an alignment for GFF3963 and 55 homologs with ≥ 30% identity
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7r8bB / Q9H221 The structure of human abcg5/abcg8 supplemented with cholesterol (see paper)
28% identity, 75% coverage of query (89.4 bits)
ABCG8_HUMAN / Q9H221 ATP-binding cassette sub-family G member 8; Sterolin-2; EC 7.6.2.- from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.204.5 / Q9H221 ABCG8 aka ATP-binding cassette sub-family G member 8, component of The ABCG5 (sterolin-1)/ABCG8 (sterolin-2) heterodimeric neutral sterol (cholesterol and plant sterols) (e.g., sitosterol) (phosphoryl donors ATP > CTP > GTP > UTP) exporter; present in the apical membranes of enterocytes and hepatocytes. Cholesteryl oleate, phosphatidyl choline and enantiomeric cholesterol are poorly transported (mutation of either ABCG5 or ABCG8 cause sitosterolemia and coronary atherosclerosis) (Zhang et al., 2006; Wang et al., 2006; 2011) from Homo sapiens (Human) (see 7 papers)
ABCG8 / RF|NP_071882.1 ATP-binding cassette sub-family G member 8 from Homo sapiens (see paper)
28% identity, 75% coverage of query (89.4 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
27% identity, 79% coverage of query (85.1 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
27% identity, 79% coverage of query (81.3 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
26% identity, 92% coverage of query (75.1 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
27% identity, 92% coverage of query (70.9 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
22% identity, 71% coverage of query (70.9 bits)
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Lawrence Berkeley National Laboratory