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Searching for up to 100 curated homologs for GFF4021 FitnessBrowser__psRCH2:GFF4021 (476 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AKECT_STUS1 / A4VFY3 Aspartate kinase Ask_Ect; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see paper)
ask / CBM40643.1 aspartokinase from Pseudomonas stutzeri (see paper)
    98% identity, 100% coverage of query (961 bits)

Build an alignment

Build an alignment for GFF4021 and 1 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q5JK18 aspartate kinase (EC 2.7.2.4) from Oryza sativa Japonica Group (see paper)
    25% identity, 98% coverage of query (99.8 bits)

Q57991 aspartate kinase (EC 2.7.2.4) from Methanocaldococcus jannaschii (see 2 papers)
    24% identity, 98% coverage of query (99.0 bits)

2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate
    24% identity, 97% coverage of query (97.1 bits)

AK_YEAST / P10869 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P10869 aspartate kinase (EC 2.7.2.4) from Saccharomyces cerevisiae (see paper)
    25% identity, 97% coverage of query (96.7 bits)

AK2_ARATH / O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23653 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana (see 2 papers)
    25% identity, 98% coverage of query (95.9 bits)

3c1mC / Q57991 Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
    24% identity, 97% coverage of query (95.9 bits)

3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine
    24% identity, 97% coverage of query (93.2 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    23% identity, 97% coverage of query (91.7 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    23% identity, 96% coverage of query (90.5 bits)

Q9RUL9 aspartate kinase (EC 2.7.2.4) from Deinococcus radiodurans (see paper)
    26% identity, 97% coverage of query (88.2 bits)

O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    24% identity, 97% coverage of query (80.9 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    24% identity, 97% coverage of query (69.7 bits)

N515DRAFT_4002 aspartate kinase / diaminopimelate decarboxylase (EC 4.1.1.20; EC 2.7.2.4) from Dyella japonica UNC79MFTsu3.2
    23% identity, 96% coverage of query (64.7 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    23% identity, 97% coverage of query (63.9 bits)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    22% identity, 96% coverage of query (61.6 bits)

FUB3_GIBM7 / W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 10 papers)
    22% identity, 97% coverage of query (50.4 bits)

2j0wA / P08660 Crystal structure of e. Coli aspartokinase iii in complex with aspartate and adp (r-state) (see paper)
    23% identity, 97% coverage of query (46.6 bits)

2j0xA Crystal structure of e. Coli aspartokinase iii in complex with lysine and aspartate (t-state)
    23% identity, 97% coverage of query (46.6 bits)

Apk / b4024 aspartate kinase III (EC 2.7.2.4) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lysC / P08660 aspartate kinase III (EC 2.7.2.4) from Escherichia coli (strain K12) (see 27 papers)
AK3_ECOLI / P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12) (see 2 papers)
P08660 aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    23% identity, 97% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory