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Searching for up to 100 curated homologs for GFF4026 FitnessBrowser__psRCH2:GFF4026 (367 a.a.)

Found high-coverage hits (≥70%) to 47 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5cm6A Crystal structure of a trap periplasmic solute binding protein from pseudoalteromonas atlantica t6c(patl_2292, target efi-510180) with bound sodium and pyruvate
    46% identity, 85% coverage of query (297 bits)

4petA / Q48AL6 Crystal structure of a trap periplasmic solute binding protein from colwellia psychrerythraea (cps_0129, target efi-510097) with bound calcium and pyruvate (see paper)
    43% identity, 87% coverage of query (286 bits)

TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
    43% identity, 100% coverage of query (281 bits)

7ug8B / Q0I6F8 Crystal structure of a solute receptor from synechococcus cc9311 in complex with alpha-ketovaleric and calcium
    42% identity, 87% coverage of query (261 bits)

TAKP_CERS4 / Q3J1R2 Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
    39% identity, 88% coverage of query (245 bits)

2hzlB / Q3J1R2 Crystal structures of a sodium-alpha-keto acid binding subunit from a trap transporter in its closed forms (see paper)
    39% identity, 89% coverage of query (245 bits)

TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    41% identity, 83% coverage of query (243 bits)

4yicA / A0A0J9X284 Crystal structure of a trap transporter solute binding protein (ipr025997) from bordetella bronchiseptica rb50 (bb0280, target efi- 500035) with bound picolinic acid
    38% identity, 89% coverage of query (238 bits)

TLBP_THET8 / Q5SK82 Lactate-binding periplasmic protein TTHA0766; ABC transporter, solute-binding protein; Extracytoplasmic solute receptor protein TTHA0766; TRAP transporter lactate-binding subunit P from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    31% identity, 75% coverage of query (129 bits)

2zzvA / Q5SK82 Crystal structure of a periplasmic substrate binding protein in complex with calcium and lactate (see paper)
    31% identity, 75% coverage of query (127 bits)

2zzwA Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
    31% identity, 75% coverage of query (127 bits)

Build an alignment

Build an alignment for GFF4026 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4pe3A / A3PQU4 Crystal structure of a trap periplasmic solute binding protein from rhodobacter sphaeroides (rsph17029_3620, target efi-510199), apo open structure (see paper)
    27% identity, 77% coverage of query (102 bits)

4xf5A / Q1QZR9 Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound (s)-(+)-2-amino-1-propanol.
    26% identity, 85% coverage of query (89.4 bits)

4uabA Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound ethanolamine
    26% identity, 85% coverage of query (89.4 bits)

TC 2.A.56.3.2 / Q9RBR1 FcbT1, component of Tripartite 4-chlorobenzoate symporter (also binds and may transport 4-bromo-, 4-iodo-, and 4-fluorobenzoate and with a lower affinity, 3-chlorobenzoate, 2-chlorobenzoate, 4-hydroxybenzoate, 3-hydroxybenzoate, and benzoate) (see paper)
    24% identity, 75% coverage of query (75.1 bits)

PP_1169 D-glucuronate / D-galacturonate TRAP transporter, solute receptor component from Pseudomonas putida KT2440
    25% identity, 74% coverage of query (68.6 bits)

7nrrBBB / Q1R0W5 7nrrBBB (see paper)
    26% identity, 81% coverage of query (65.1 bits)

7nrrAAA / Q1R0W5 7nrrAAA (see paper)
    26% identity, 81% coverage of query (65.1 bits)

7nswBBB TRAP dicarboxylate transporter-DctP subunit
    26% identity, 81% coverage of query (65.1 bits)

7ntdAAA TRAP dicarboxylate transporter-DctP subunit
    26% identity, 81% coverage of query (64.7 bits)

TC 2.A.56.1.9 / R4JTF7 Putative TRAP transporter solute receptor DctP, component of The possible disulfide 3,3'-dithiodipropionic acid (DTDP) tripartite transporter, DctMPQ from Advenella mimigardefordensis DPN7
    24% identity, 75% coverage of query (64.3 bits)

7bbrA / R4JTF7 Crystal structure of the sugar acid binding protein dctpam from advenella mimigardefordensis strain dpn7t (see paper)
    24% identity, 75% coverage of query (64.3 bits)

7bcrA Crystal structure of the sugar acid binding protein dctpam from advenella mimigardefordensis strain dpn7t in complex with galactonate
    24% identity, 75% coverage of query (64.3 bits)

7bcpA Crystal structure of the sugar acid binding protein dctpam from advenella mimigardefordensis strain dpn7t in complex with gluconate
    24% identity, 75% coverage of query (64.3 bits)

7bcoA Crystal structure of the sugar acid binding protein dctpam from advenella mimigardefordensis strain dpn7t in complex with d-foconate
    24% identity, 75% coverage of query (64.3 bits)

7bcnA Crystal structure of the sugar acid binding protein dctpam from advenella mimigardefordensis strain dpn7t in complex with xylonic acid
    24% identity, 75% coverage of query (64.3 bits)

4xfeA / I3UZ52 Crystal structure of a trap periplasmic solute binding protein from pseudomonas putida f1 (pput_1203), target efi-500184, with bound d- glucuronate
    25% identity, 72% coverage of query (63.9 bits)

2pfyA / Q7VXB1 Crystal structure of dctp7, a bordetella pertussis extracytoplasmic solute receptor binding pyroglutamic acid (see paper)
    28% identity, 71% coverage of query (62.8 bits)

4n6dA / C6C297 Crystal structure of a trap periplasmic solute binding protein from desulfovibrio salexigens dsm2638 (desal_3247), target efi-510112, phased with i3c, open complex, c-terminus of symmetry mate bound in ligand binding site (see paper)
    22% identity, 74% coverage of query (61.2 bits)

Psest_2125 D-gluconate TRAP transporter, periplasmic component from Pseudomonas stutzeri RCH2
    25% identity, 73% coverage of query (59.7 bits)

Ac3H11_3226 gluconate TRAP transporter, periplasmic solute-binding component from Acidovorax sp. GW101-3H11
    26% identity, 75% coverage of query (59.3 bits)

4pgpA Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634, target efi-510120) with bound 3-indole acetic acid
    25% identity, 74% coverage of query (58.5 bits)

4pgnA Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634, target efi-510120) with bound indole pyruvate
    25% identity, 74% coverage of query (58.5 bits)

4napD / Q315G1 Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634), target efi-510102, with bound d-tryptophan (see paper)
    25% identity, 74% coverage of query (58.5 bits)

3gyyD / E1VBK1 The ectoine binding protein of the teaabc trap transporter teaa in the apo-state (see paper)
    25% identity, 76% coverage of query (57.0 bits)

TEAA_HALED / E1VBK1 Ectoine-binding periplasmic protein TeaA from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) (see 3 papers)
    25% identity, 77% coverage of query (57.0 bits)

2vpnB High-resolution structure of the periplasmic ectoine- binding protein from teaabc trap-transporter of halomonas elongata
    25% identity, 70% coverage of query (55.8 bits)

4p56B / A0A0H3LM73 Crystal structure of a trap periplasmic solute binding protein from bordetella bronchiseptica, target efi-510038 (bb2442), with bound (r)-mandelate and (s)-mandelate (see paper)
    22% identity, 71% coverage of query (55.5 bits)

4p56A Crystal structure of a trap periplasmic solute binding protein from bordetella bronchiseptica, target efi-510038 (bb2442), with bound (r)-mandelate and (s)-mandelate
    22% identity, 71% coverage of query (55.5 bits)

4ovrA / A7IKQ4 Crystal structure of a trap periplasmic solute binding protein from xanthobacter autotrophicus py2, target efi-510329, with bound beta-d- galacturonate (see paper)
    23% identity, 72% coverage of query (53.9 bits)

4x04A / A8AR30 Crystal structure of a trap periplasmic solute binding protein from citrobacter koseri (cko_04899, target efi-510094) with bound d- glucuronate
    26% identity, 73% coverage of query (53.9 bits)

2vpoA High resolution structure of the periplasmic binding protein teaa from teaabc trap transporter of halomonas elongata in complex with hydroxyectoine
    25% identity, 76% coverage of query (53.9 bits)

2vpnA High-resolution structure of the periplasmic ectoine- binding protein from teaabc trap-transporter of halomonas elongata
    25% identity, 70% coverage of query (52.8 bits)

2pfzA / Q7VXB3 Crystal structure of dctp6, a bordetella pertussis extracytoplasmic solute receptor binding pyroglutamic acid (see paper)
    24% identity, 83% coverage of query (49.3 bits)

DCTP_ALBFT / Q21XD7 Solute-binding protein Rfer_1840 from Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens) (see paper)
    26% identity, 70% coverage of query (48.9 bits)

AZOBR_RS15915 gluconate TRAP transporter, periplasmic solute-binding component from Azospirillum brasilense Sp245
    24% identity, 77% coverage of query (47.0 bits)

4oanA / Q2IWM2 Crystal structure of a trap periplasmic solute binding protein from rhodopseudomonas palustris haa2 (rpb_2686), target efi-510221, with density modeled as (s)-2-hydroxy-2-methyl-3-oxobutanoate ((s)-2- acetolactate) (see paper)
    21% identity, 73% coverage of query (47.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory