Searching for up to 100 curated homologs for GFF4056 FitnessBrowser__psRCH2:GFF4056 (495 a.a.)
Found high-coverage hits (≥70%) to 31 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
73% identity, 100% coverage of query (738 bits)
TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
61% identity, 100% coverage of query (582 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
61% identity, 96% coverage of query (553 bits)
Build an alignment for GFF4056 and 3 homologs with ≥ 30% identity
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BICA_PICP2 / Q14SY0 Bicarbonate transporter BicA from Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
28% identity, 73% coverage of query (164 bits)
DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
27% identity, 95% coverage of query (145 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
25% identity, 97% coverage of query (142 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
27% identity, 93% coverage of query (137 bits)
6ki1B / Q55415 The transmembrane domain of a cyanobacterium bicarbonate transporter bica (see paper)
29% identity, 73% coverage of query (135 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
26% identity, 94% coverage of query (135 bits)
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
27% identity, 88% coverage of query (125 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 76% coverage of query (123 bits)
7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
27% identity, 76% coverage of query (123 bits)
7v74A Thermostabilized human prestin in complex with sulfate
25% identity, 97% coverage of query (110 bits)
P96878 carbonic anhydrase (EC 4.2.1.1) from Mycobacterium tuberculosis (see paper)
TC 2.A.53.3.12 / P96878 A bicarbonate transporter fused to a carbonic anhydrase, Rv3273 from Mycobacterium tuberculosis
29% identity, 77% coverage of query (108 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
24% identity, 97% coverage of query (106 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
26% identity, 75% coverage of query (95.9 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
21% identity, 95% coverage of query (87.0 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
21% identity, 94% coverage of query (85.1 bits)
S26A5_HUMAN / P58743 Prestin; Solute carrier family 26 member 5 from Homo sapiens (Human) (see 2 papers)
TC 2.A.53.2.19 / P58743 Prestin (Solute carrier family 26 member 5) from Homo sapiens (see 3 papers)
21% identity, 96% coverage of query (85.1 bits)
S26A5_CHICK / A0FKN5 Prestin; Solute carrier family 26 member 5 from Gallus gallus (Chicken) (see 5 papers)
TC 2.A.53.2.9 / A0FKN5 The electrogenic divalent anion: chloride exchanger (1:1 stoichiometry) (transports sulfate, chloride, and oxalate) from Gallus gallus (Chicken) (see paper)
22% identity, 86% coverage of query (84.0 bits)
S26A5_MERUN / Q9JKQ2 Prestin; Solute carrier family 26 member 5 from Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) (see 4 papers)
21% identity, 97% coverage of query (83.2 bits)
TC 2.A.53.2.5 / Q99NH7 Prestin, the outer hair cell voltage-sensitive motor protein (voltage sensitivity depends on intracellular Cl- and HCO3- which may bind to prestin). Prestin transports anions including formate and oxalate; transport and voltage-sensing capabilities are independent functions of the same protein (Bai et al., 2009). Prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility from Mus musculus (Mouse) (see paper)
Slc26a5 / GB|AAG59999.2 prestin from Mus musculus
21% identity, 96% coverage of query (83.2 bits)
S26A5_RAT / Q9EPH0 Prestin; Solute carrier family 26 member 5 from Rattus norvegicus (Rat) (see 11 papers)
21% identity, 96% coverage of query (82.8 bits)
S26A5_MOUSE / Q99NH7 Prestin; Solute carrier family 26 member 5 from Mus musculus (Mouse) (see 5 papers)
21% identity, 96% coverage of query (82.4 bits)
S26A6_HUMAN / Q9BXS9 Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 from Homo sapiens (Human) (see 7 papers)
TC 2.A.53.2.7 / Q9BXS9 The human Slc26a6 anion exchanger (transports sulfate, formate, oxalate, chloride and bicarbonate in antiport with any one of these anions) (Jiang et al., 2002). However, Cl- and HSO4- are transported slowly; Cl-/HCO3-, Cl-/OH- and Cl-:oxalate exchange reactions are electroneutral (Chernova et al., 2005). (The oxalate nephrolithiasis gene; Clark et al., 2008). Catalyzes 1Cl-/2HCO3- antiport from Homo sapiens (Human) (see 4 papers)
23% identity, 85% coverage of query (82.4 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 75% coverage of query (76.3 bits)
S26A1_HUMAN / Q9H2B4 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Homo sapiens (Human) (see 4 papers)
TC 2.A.53.2.16 / Q9H2B4 Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger. Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003). The mouse and rat orthologues have the same specificities and functions. Loss in mice is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013). When homozygous, they can cause severe nephrocalcinosis from Homo sapiens (see 5 papers)
25% identity, 76% coverage of query (66.6 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
24% identity, 76% coverage of query (63.9 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
23% identity, 76% coverage of query (62.0 bits)
7ch1A / Q7LBE3 The overall structure of slc26a9 (see paper)
20% identity, 95% coverage of query (59.3 bits)
S26A9_HUMAN / Q7LBE3 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Homo sapiens (Human) (see 5 papers)
TC 2.A.53.2.15 / Q7LBE3 Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) from Homo sapiens (see 4 papers)
20% identity, 79% coverage of query (53.9 bits)
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Lawrence Berkeley National Laboratory