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Searching for up to 100 curated homologs for GFF4208 HP15_4148 glucose-methanol-choline oxidoreductase (542 a.a.)

Found high-coverage hits (≥70%) to 93 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AAX23098.1 alcohol dehydrogenase from Alcanivorax borkumensis SK2 (see paper)
    49% identity, 100% coverage of query (498 bits)

Q76HN6 alcohol dehydrogenase (EC 1.1.1.1) from Pseudomonas putida (see paper)
    49% identity, 97% coverage of query (491 bits)

alkJ / Q00593 octanol dehydrogenase from Pseudomonas oleovorans (see 3 papers)
alkJ / CAB54054.1 alcohol dehydrogenase from Pseudomonas putida (see 6 papers)
    42% identity, 98% coverage of query (431 bits)

CHDH_RAT / Q6UPE0 Choline dehydrogenase, mitochondrial; CDH; CHD; EC 1.1.99.1 from Rattus norvegicus (Rat) (see paper)
Q6UPE0 choline dehydrogenase (EC 1.1.99.1) from Rattus norvegicus (see 2 papers)
    43% identity, 98% coverage of query (415 bits)

CHDH / Q8NE62 choline dehydrogenase (EC 1.1.99.1) from Homo sapiens (see 4 papers)
Q8NE62 choline dehydrogenase (EC 1.1.99.1) from Homo sapiens (see 3 papers)
    43% identity, 98% coverage of query (409 bits)

CHDH_MOUSE / Q8BJ64 Choline dehydrogenase, mitochondrial; CDH; CHD; EC 1.1.99.1 from Mus musculus (Mouse) (see paper)
Q8BJ64 choline dehydrogenase (EC 1.1.99.1) from Mus musculus (see 2 papers)
    42% identity, 98% coverage of query (407 bits)

BETA2_CHRSD / Q9L4K0 Oxygen-dependent choline dehydrogenase; CDH; CHD; EC 1.1.99.1 from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
    43% identity, 98% coverage of query (401 bits)

betA / P54223 choline dehydrogenase (EC 1.1.99.1) from Rhizobium meliloti (strain 1021) (see 2 papers)
BETA_RHIME / P54223 Oxygen-dependent choline dehydrogenase; CDH; CHD; Betaine aldehyde dehydrogenase; BADH; EC 1.1.99.1; EC 1.2.1.8 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    41% identity, 97% coverage of query (390 bits)

mlr6792 / Q988C9 4-pyridoxate dehydrogenase (EC 1.1.99.42) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (see 3 papers)
4PADH_RHILO / Q988C9 4-pyridoxate dehydrogenase; 4-pyridoxic acid dehydrogenase; 4-PADH; EC 1.1.99.42 from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) (see paper)
Q988C9 4-pyridoxic acid dehydrogenase (EC 1.1.99.42) from Mesorhizobium loti (see 2 papers)
    41% identity, 99% coverage of query (389 bits)

BetA / b0311 choline dehydrogenase (EC 1.1.99.1) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
betA / P17444 choline dehydrogenase (EC 1.1.99.1) from Escherichia coli (strain K12) (see 5 papers)
BETA_ECOLI / P17444 Oxygen-dependent choline dehydrogenase; CDH; CHD; Betaine aldehyde dehydrogenase; BADH; EC 1.1.99.1; EC 1.2.1.8 from Escherichia coli (strain K12) (see 3 papers)
betA / GB|AP_000964.1 choline dehydrogenase; EC 1.1.99.1 from Escherichia coli K12 (see 4 papers)
betA / AAA23504.1 choline dehydrogenase from Escherichia coli (see paper)
    42% identity, 98% coverage of query (386 bits)

phcD / G2INY6 (-)-dehydrodiconiferyl acid dehydrogenase/hydroxylase from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
    41% identity, 97% coverage of query (380 bits)

phcC / G2INY4 (+)-dehydrodiconiferyl acid dehydrogenase from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
    42% identity, 99% coverage of query (379 bits)

BAA13144 / Q47944 L-sorbose dehydrogenase, FAD dependent (EC 1.1.99.32) from Gluconobacter oxydans (see paper)
    38% identity, 97% coverage of query (361 bits)

dddA / C8YX89 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) from Halomonas sp. HTNK1 (see paper)
    40% identity, 98% coverage of query (354 bits)

Q2HXX0 alkan-1-ol dehydrogenase (acceptor) (EC 1.1.99.20) from Ensifer sp. AS08 (see paper)
    39% identity, 98% coverage of query (346 bits)

ntnD / O52645 4-nitrobenzyl alcohol oxidase from Pseudomonas sp. TW3 (see paper)
    36% identity, 96% coverage of query (305 bits)

5nccA / A0A248QE08 Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
    36% identity, 97% coverage of query (304 bits)

FAP_CHLRE / A8JHB7 Fatty acid photodecarboxylase, chloroplastic; CrFAP; EC 4.1.1.106 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 2 papers)
    35% identity, 97% coverage of query (301 bits)

FAP_CHLVA / A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see 5 papers)
    35% identity, 97% coverage of query (298 bits)

6yrvAAA structure of fap after illumination at 100k
    35% identity, 97% coverage of query (297 bits)

A0A173MZJ8 (R)-mandelonitrile oxidase (EC 1.1.3.49) from Chamberlinius hualienensis (see paper)
    36% identity, 98% coverage of query (281 bits)

8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
    35% identity, 99% coverage of query (280 bits)

B4F334 aryl-alcohol oxidase (EC 1.1.3.7) from Chrysomela tremula (see paper)
sao / CAQ19343.1 salicyl alcohol oxidase precursor from Chrysomela tremula (see paper)
    33% identity, 98% coverage of query (268 bits)

B4F335 aryl-alcohol oxidase (EC 1.1.3.7) from Chrysomela populi (see paper)
sao / CAQ19344.1 salicyl alcohol oxidase precursor from Chrysomela populi (see paper)
    34% identity, 98% coverage of query (263 bits)

EO / H6AGY0 ecdysone oxidase (EC 1.1.3.16) from Bombyx mori (see 2 papers)
EO_BOMMO / H6AGY0 Ecdysone oxidase; BmEO; EC 1.1.3.16 from Bombyx mori (Silk moth) (see 3 papers)
H6AGY0 ecdysone oxidase (EC 1.1.3.16) from Bombyx mori (see 2 papers)
AEM17059.1 ecdysone oxidase (BmEO;BGIBMGA005692) (EC 1.1.3.16) (see protein)
    35% identity, 99% coverage of query (258 bits)

codA / Q7X2H8 choline oxidase subunit (EC 1.1.3.17) from Arthrobacter globiformis (see 3 papers)
CHOX_ARTGO / Q7X2H8 Choline oxidase; EC 1.1.3.17 from Arthrobacter globiformis (see 2 papers)
Q7X2H8 alcohol oxidase (EC 1.1.3.13); choline oxidase (EC 1.1.3.17) from Arthrobacter globiformis (see 24 papers)
    34% identity, 99% coverage of query (257 bits)

4mjwA / Q7X2H8 Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
    34% identity, 99% coverage of query (255 bits)

2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism
    34% identity, 97% coverage of query (253 bits)

3ljpA Crystal structure of choline oxidase v464a mutant
    34% identity, 97% coverage of query (251 bits)

D9ZFI1 glucose oxidase (EC 1.1.3.4) from Spodoptera exigua (see paper)
    34% identity, 98% coverage of query (250 bits)

A0A4Y3W1Z2 choline oxidase (EC 1.1.3.17) from Glutamicibacter nicotianae (see paper)
    33% identity, 99% coverage of query (249 bits)

B2MW81 glucose oxidase (EC 1.1.3.4) from Helicoverpa armigera (see paper)
    33% identity, 98% coverage of query (246 bits)

ERIK_HERER / P0DO29 Dehydrogenase eriK; Erinacine biosynthesis cluster protein K; EC 1.1.-.- from Hericium erinaceus (Lion's mane mushroom) (Hydnum erinaceus) (see 2 papers)
    33% identity, 98% coverage of query (243 bits)

B8NHY3 versicolorin B synthase (EC 4.2.1.143) from Aspergillus flavus (see 2 papers)
    33% identity, 98% coverage of query (242 bits)

aflK / Q12062 versiconal cyclase subunit (EC 4.2.1.143) from Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) (see paper)
AFLK_ASPPU / Q12062 Versicolorin B synthase; 5'-oxoaverantin cyclase; Aflatoxin biosynthesis protein K; EC 4.2.1.143; EC 4.2.1.142 from Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) (see 8 papers)
Q12062 5'-oxoaverantin cyclase (EC 4.2.1.142); versicolorin B synthase (EC 4.2.1.143) from Aspergillus parasiticus (see 5 papers)
    33% identity, 98% coverage of query (240 bits)

PNO_MICLT / Q9AJD6 Pyridoxine 4-oxidase; EC 1.1.3.12 from Microbacterium luteolum (Aureobacterium luteolum) (see paper)
Q9AJD6 pyridoxine 4-oxidase (EC 1.1.3.12) from Microbacterium luteolum (see 2 papers)
    32% identity, 96% coverage of query (238 bits)

PKFF_EMENI / Q5B8A1 Dehydrogenase pkfF; EC 1.1.-.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
    31% identity, 98% coverage of query (238 bits)

hmfH / E4QP00 5-hydroxymethylfurfural oxidase (EC 1.1.3.47) from Methylovorus sp. (strain MP688) (see 3 papers)
HMFO_METS6 / E4QP00 5-(hydroxymethyl)furfural oxidase; 5-hydroxymethylfurfural oxidase; HMFO; Thiol oxidase; EC 1.1.3.47; EC 1.8.3.- from Methylovorus sp. (strain MP688) (see 3 papers)
E4QP00 vanillyl-alcohol oxidase (EC 1.1.3.38); 5-(hydroxymethyl)furfural oxidase (EC 1.1.3.47); aryl-alcohol oxidase (EC 1.1.3.7) from Methylovorus sp. MP688 (see 10 papers)
    33% identity, 99% coverage of query (236 bits)

4udqA / E4QP00 Crystal structure of 5-hydroxymethylfurfural oxidase (hmfo) in the reduced state
    34% identity, 98% coverage of query (236 bits)

GMCH_MALS4 / M5EAX2 GMC oxidoreductase family protein Mala s 12; Allergen Mala s 12; EC 1.-.-.- from Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated yeast) (see paper)
GMCH_MALSM / Q5GMY3 GMC oxidoreductase family protein Mala s 12.0101; Allergen Mala s 12.0101; EC 1.-.-.- from Malassezia sympodialis (Atopic eczema-associated yeast) (see paper)
    32% identity, 98% coverage of query (233 bits)

CITC_MONPU / A0A142PTM2 Dehydrogenase mpl7; Citrinin synthesis protein mpl7; EC 1.1.-.- from Monascus purpureus (Red mold) (Monascus anka) (see 4 papers)
CITC_MONRU / A0A161CEV4 Dehydrogenase citC; Citrinin synthesis protein C; EC 1.1.-.- from Monascus ruber (Mold) (see paper)
    32% identity, 98% coverage of query (233 bits)

AY035785 / Q95NZ0 ecdysone oxidase (EC 1.1.3.16) from Spodoptera littoralis (see 3 papers)
EO_SPOLI / Q95NZ0 Ecdysone oxidase; EC 1.1.3.16 from Spodoptera littoralis (Egyptian cotton leafworm) (see paper)
    31% identity, 97% coverage of query (232 bits)

pno / Q988D6 pyridoxine 4-oxidase (EC 1.1.3.12) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (see 4 papers)
Q5NT46 pyridoxine 4-oxidase (EC 1.1.3.12) from Mesorhizobium loti (see 2 papers)
    34% identity, 97% coverage of query (232 bits)

3t37A / Q5NT46 Crystal structure of pyridoxine 4-oxidase from mesorbium loti
    34% identity, 97% coverage of query (232 bits)

4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex
    34% identity, 97% coverage of query (232 bits)

STR4_STRTC / A0A3B1EFP9 Dehydrogenase str4; Strobilurin A biosynthesis cluster protein r4; EC 1.1.-.- from Strobilurus tenacellus (see 3 papers)
    32% identity, 98% coverage of query (226 bits)

PDH3_LEUMG / Q0R4L2 Pyranose dehydrogenase 3; PDH 3; Pyranose:quinone oxidoreductase 3; EC 1.1.99.29 from Leucoagaricus meleagris (Western flat-topped agaric) (Agaricus meleagris) (see paper)
Q0R4L2 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Leucoagaricus meleagris (see 2 papers)
    30% identity, 98% coverage of query (225 bits)

CHOA / B0YA55 choline oxidase (EC 1.1.3.17) from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (see paper)
    31% identity, 99% coverage of query (223 bits)

B8MX95 glucose 1-dehydrogenase (FAD, quinone) (EC 1.1.5.9) from Aspergillus flavus (see 2 papers)
    31% identity, 98% coverage of query (223 bits)

PDH1_AGABI / Q3L1D1 Pyranose dehydrogenase; PDH; Glucose dehydrogenase; GDH; Pyranose 2-dehydrogenase; Pyranose:quinone oxidoreductase; EC 1.1.99.29 from Agaricus bisporus (White button mushroom) (see 2 papers)
Q3L1D1 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Agaricus bisporus (see 3 papers)
    31% identity, 98% coverage of query (223 bits)

4yntA / B8MX95 Crystal structure of aspergillus flavus fad glucose dehydrogenase (see paper)
    31% identity, 98% coverage of query (223 bits)

7vzsA Fad-dpendent glucose dehydrogenase complexed with an inhibitor at ph7.56
    31% identity, 98% coverage of query (223 bits)

4ynuA Crystal structure of aspergillus flavus fadgdh in complex with d- glucono-1,5-lactone
    31% identity, 98% coverage of query (223 bits)

A0A1E1GL61 glucose 1-dehydrogenase (FAD, quinone) (EC 1.1.5.9) from Rasamsonia emersonii (see paper)
    30% identity, 99% coverage of query (222 bits)

PDH1_AGACM / V5NDL4 Pyranose dehydrogenase; PDH; Pyranose:quinone oxidoreductase 1; EC 1.1.99.29 from Agaricus campestris (Field mushroom) (see paper)
V5NDL4 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Agaricus campestris (see 2 papers)
    31% identity, 98% coverage of query (222 bits)

PDH1_AGAXA / V5NC32 Pyranose dehydrogenase; PDH; Pyranose:quinone oxidoreductase 1; EC 1.1.99.29 from Agaricus xanthodermus (Poison yellow meadow mushroom) (see 2 papers)
V5NC32 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Agaricus xanthodermus (see 2 papers)
    31% identity, 98% coverage of query (222 bits)

Build an alignment

Build an alignment for GFF4208 and 56 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5oc1A Crystal structure of aryl-alcohol oxidase from pleurotus eryngii in complex with p-anisic acid
    29% identity, 97% coverage of query (222 bits)

3fimB / O94219 Crystal structure of aryl-alcohol-oxidase from pleurotus eryingii (see paper)
    29% identity, 97% coverage of query (220 bits)

aao / O94219 aryl-alcohol oxidase (EC 1.1.3.7) from Pleurotus eryngii (see paper)
O94219 5-(hydroxymethyl)furfural oxidase (EC 1.1.3.47); aryl-alcohol oxidase (EC 1.1.3.7) from Pleurotus eryngii (see 15 papers)
AAC72747.1 aryl-alcohol oxidase (AaO) (EC 1.1.3.7) (see protein)
aao / AAC72747.1 aryl-alcohol oxidase precursor from Pleurotus eryngii (see 2 papers)
    29% identity, 97% coverage of query (220 bits)

D3YBH4 aryl-alcohol oxidase (EC 1.1.3.7) from Pleurotus eryngii (see paper)
    29% identity, 97% coverage of query (219 bits)

D5KB61 5-(hydroxymethyl)furfural oxidase (EC 1.1.3.47) from Cupriavidus basilensis (see paper)
    33% identity, 97% coverage of query (219 bits)

AAF31169.1 aryl-alcohol oxidase (AaO) (EC 1.1.3.7) (see protein)
    29% identity, 97% coverage of query (219 bits)

PDH2_LEUMG / Q3L243 Pyranose dehydrogenase 2; PDH 2; Pyranose:quinone oxidoreductase 2; EC 1.1.99.29 from Leucoagaricus meleagris (Western flat-topped agaric) (Agaricus meleagris) (see paper)
Q3L243 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Leucoagaricus meleagris (see 2 papers)
    30% identity, 98% coverage of query (219 bits)

A0A145Y386 aryl-alcohol oxidase (EC 1.1.3.7) from Pleurotus sapidus (see paper)
    29% identity, 97% coverage of query (217 bits)

ARMD5_ARMGA / A0A2H3D1U1 Dehydrogenase ARMGADRAFT_1018426; Melleolide biosynthesis cluster protein ARMGADRAFT_1018426; EC 1.1.1.- from Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa) (see 9 papers)
    31% identity, 98% coverage of query (216 bits)

gdh / G8E4B4 glucose dehydrogenase (quinone) (EC 1.1.5.9) from Colletotrichum gloeosporioides (see 10 papers)
    31% identity, 98% coverage of query (215 bits)

Q0CDD9 glucose 1-dehydrogenase (FAD, quinone) (EC 1.1.5.9) from Aspergillus terreus (see paper)
    31% identity, 97% coverage of query (214 bits)

6xuuA Crystallographic structure of oligosaccharide dehydrogenase from pycnoporus cinnabarinus, glucose-bound form
    31% identity, 98% coverage of query (204 bits)

6xutA / A0A060SC37 Crystallographic structure of oligosaccharide dehydrogenase from pycnoporus cinnabarinus, ligand-free form (see paper)
    31% identity, 98% coverage of query (204 bits)

PDH1_LEUMG / Q3L245 Pyranose dehydrogenase 1; PDH 1; Pyranose:quinone oxidoreductase 1; EC 1.1.99.29 from Leucoagaricus meleagris (Western flat-topped agaric) (Agaricus meleagris) (see 3 papers)
Q3L245 pyranose dehydrogenase (acceptor) (EC 1.1.99.29) from Leucoagaricus meleagris (see 12 papers)
    29% identity, 98% coverage of query (202 bits)

4h7uA / Q3L245 Crystal structure of pyranose dehydrogenase from agaricus meleagris, wildtype (see paper)
    29% identity, 98% coverage of query (202 bits)

8bxlB / A0A075TRK9 Patulin synthase from penicillium expansum
    29% identity, 97% coverage of query (199 bits)

3q9tA / Q2UD26 Crystal structure analysis of formate oxidase (see paper)
    30% identity, 97% coverage of query (195 bits)

5zu2A Effect of mutation (r554a) on fad modification in aspergillus oryzae rib40formate oxidase
    30% identity, 97% coverage of query (194 bits)

5nitA Glucose oxidase mutant a2
    30% identity, 99% coverage of query (170 bits)

1cf3A / P13006 Glucose oxidase from apergillus niger (see paper)
    30% identity, 99% coverage of query (170 bits)

6h3oF / T2M2J4 Alcohol oxidase from phanerochaete chrysosporium mutant f101s (see paper)
    26% identity, 98% coverage of query (161 bits)

5i68A Alcohol oxidase from pichia pastoris
    29% identity, 85% coverage of query (161 bits)

5hsaA / F2QY27 Alcohol oxidase aox1 from pichia pastoris (see paper)
    29% identity, 85% coverage of query (161 bits)

6h3gB Alcohol oxidase from phanerochaete chrysosporium
    26% identity, 98% coverage of query (160 bits)

P81156 glucose oxidase (EC 1.1.3.4) from Penicillium amagasakiense (see 4 papers)
1gpeB / P81156 Glucose oxidase from penicillium amagasakiense (see paper)
    28% identity, 99% coverage of query (160 bits)

3redA / B9X0I1 3.0 a structure of the prunus mume hydroxynitrile lyase isozyme-1
    27% identity, 94% coverage of query (115 bits)

3gdnA / Q945K2 Almond hydroxynitrile lyase in complex with benzaldehyde (see paper)
    24% identity, 99% coverage of query (109 bits)

MDL2_PRUDU / Q945K2 (R)-mandelonitrile lyase 2; Hydroxynitrile lyase 2; (R)-oxynitrilase 2; PaHNL1; R-oxynitrile lyase isoenzyme 2; EC 4.1.2.10 from Prunus dulcis (Almond) (Amygdalus dulcis) (see 3 papers)
    24% identity, 99% coverage of query (108 bits)

6jbyA / O24243 Crystal structure of endo-deglycosylated hydroxynitrile lyase isozyme 5 of prunus communis
    27% identity, 94% coverage of query (103 bits)

6lqyA Crystal complex of endo-deglycosylated hydroxynitrile lyase isozyme 5 of prunus communis with benzaldehyde
    27% identity, 94% coverage of query (102 bits)

7bwpA Crystal complex of endo-deglycosylated pchnl5 with (r)-mandelonitrile
    27% identity, 94% coverage of query (100 bits)

5eb5A The crystal structure of almond hnl, pahnl5 v317a, in complex with benzyl alcohol
    26% identity, 94% coverage of query (98.6 bits)

HTH / Q9S746 ω-hydroxy fatty acid ω-alcohol dehydrogenase from Arabidopsis thaliana (see paper)
HTH_ARATH / Q9S746 Protein HOTHEAD; Protein ADHESION OF CALYX EDGES from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    24% identity, 99% coverage of query (94.0 bits)

4qi7B Cellobiose dehydrogenase from neurospora crassa, nccdh
    25% identity, 83% coverage of query (86.3 bits)

4qi7A / Q7RXM0 Cellobiose dehydrogenase from neurospora crassa, nccdh (see paper)
    25% identity, 83% coverage of query (85.9 bits)

4qi5A Dehydrogenase domain of myriococcum thermophilum cellobiose dehydrogenase with bound cellobionolactam, mtdh
    25% identity, 83% coverage of query (76.3 bits)

4qi6A / A9XK88 Cellobiose dehydrogenase from myriococcum thermophilum, mtcdh (see paper)
    25% identity, 83% coverage of query (75.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory