Searching for up to 100 curated homologs for GFF4241 Psest_4314 ABC-type metal ion transport system, ATPase component (335 a.a.)
Found high-coverage hits (≥70%) to 54 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
85% identity, 100% coverage of query (579 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
51% identity, 94% coverage of query (318 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
47% identity, 100% coverage of query (296 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
47% identity, 100% coverage of query (294 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
47% identity, 100% coverage of query (294 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
47% identity, 100% coverage of query (294 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
45% identity, 100% coverage of query (290 bits)
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
45% identity, 96% coverage of query (265 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
46% identity, 72% coverage of query (194 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
43% identity, 72% coverage of query (189 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
43% identity, 72% coverage of query (189 bits)
2olkA Abc protein artp in complex with adp-beta-s
43% identity, 72% coverage of query (189 bits)
2oljA Abc protein artp in complex with adp/mg2+
43% identity, 72% coverage of query (189 bits)
ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
43% identity, 72% coverage of query (188 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
41% identity, 72% coverage of query (187 bits)
TC 3.A.1.12.9 / Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see 2 papers)
43% identity, 70% coverage of query (181 bits)
TC 3.A.1.3.25 / Q9CES4 Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
42% identity, 72% coverage of query (179 bits)
GLUA_CORGL / P48243 Glutamate transport ATP-binding protein GluA; Glutamate uptake system protein GluA; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
44% identity, 72% coverage of query (179 bits)
AO356_05515 ABC transporter for L-Lysine, ATPase component from Pseudomonas fluorescens FW300-N2C3
42% identity, 70% coverage of query (178 bits)
GLNQ_BACSU / O34677 Glutamine transport ATP-binding protein GlnQ; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
42% identity, 72% coverage of query (177 bits)
SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
42% identity, 72% coverage of query (177 bits)
YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
43% identity, 72% coverage of query (177 bits)
Q8ZQM4 ABC-type glutathione transporter (EC 7.4.2.10) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
40% identity, 75% coverage of query (177 bits)
TCYN_BACSU / O34900 L-cystine import ATP-binding protein TcyN; EC 7.4.2.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34900 TcyN (YtmN), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
43% identity, 72% coverage of query (176 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
44% identity, 70% coverage of query (168 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
44% identity, 70% coverage of query (168 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
37% identity, 72% coverage of query (147 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
36% identity, 71% coverage of query (141 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
36% identity, 71% coverage of query (140 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
36% identity, 72% coverage of query (140 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
38% identity, 73% coverage of query (140 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
33% identity, 72% coverage of query (136 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
37% identity, 71% coverage of query (135 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
35% identity, 73% coverage of query (130 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
35% identity, 73% coverage of query (130 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
35% identity, 73% coverage of query (129 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
34% identity, 73% coverage of query (129 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
34% identity, 73% coverage of query (127 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
34% identity, 83% coverage of query (123 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
33% identity, 72% coverage of query (114 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
33% identity, 72% coverage of query (112 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
33% identity, 76% coverage of query (110 bits)
8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
33% identity, 73% coverage of query (107 bits)
5d3mB Folate ecf transporter: amppnp bound state
33% identity, 73% coverage of query (107 bits)
8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
33% identity, 73% coverage of query (106 bits)
7pslA / P40416 S. Cerevisiae atm1 in msp1d1 nanodiscs in nucleotide-free state (see paper)
31% identity, 71% coverage of query (105 bits)
4myhB Structure of the glutathione bound mitochondrial abc transporter, atm1
31% identity, 71% coverage of query (105 bits)
ATM1_YEAST / P40416 Iron-sulfur clusters transporter ATM1, mitochondrial; EC 7.-.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
TC 3.A.1.210.1 / P40416 The mitochondrial iron transporter, ATM1 from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
ATM1 / RF|NP_014030.1 iron-sulfur clusters transporter ATM1, mitochondrial from Saccharomyces cerevisiae
31% identity, 71% coverage of query (105 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
34% identity, 71% coverage of query (103 bits)
4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
31% identity, 73% coverage of query (98.6 bits)
4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
31% identity, 73% coverage of query (97.8 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
34% identity, 76% coverage of query (91.7 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
35% identity, 70% coverage of query (91.7 bits)
Build an alignment for GFF4241 and 53 homologs with ≥ 30% identity
Or download the sequences
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
25% identity, 75% coverage of query (75.5 bits)
Or start over
Lawrence Berkeley National Laboratory