Searching for up to 100 curated homologs for GFF4244 FitnessBrowser__WCS417:GFF4244 (229 a.a.)
Found high-coverage hits (≥70%) to 45 curated proteins.
Removed hits that are identical to the query, leaving 44
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
AO356_18705 L-Arginine ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N2C3
98% identity, 100% coverage of query (446 bits)
Pf1N1B4_3432 ABC transporter for L-Arginine and L-Citrulline, permease component 1 from Pseudomonas fluorescens FW300-N1B4
97% identity, 100% coverage of query (444 bits)
Pf6N2E2_5661 L-Arginine ABC transporter, permease protein AotQ from Pseudomonas fluorescens FW300-N2E2
97% identity, 100% coverage of query (442 bits)
AO353_03050 ABC transporter for L-Arginine and L-Citrulline, permease component 2 from Pseudomonas fluorescens FW300-N2E3
97% identity, 100% coverage of query (439 bits)
TC 3.A.1.3.11 / O50182 AotQ, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa (see paper)
aotQ / GI|2668596 arginine/ornithine transport protein from Pseudomonas aeruginosa (see paper)
83% identity, 100% coverage of query (342 bits)
HISQ_SALTY / P0A2I9 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I9 Histidine transport system permease protein HisQ aka STM2353, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
54% identity, 100% coverage of query (231 bits)
hisQ / b2308 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisQ (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
HISQ_ECOLI / P52094 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P52094 Histidine transport system permease protein HisQ, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
53% identity, 100% coverage of query (231 bits)
Pf6N2E2_2959 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2E2
47% identity, 99% coverage of query (197 bits)
AO356_05500 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
47% identity, 99% coverage of query (197 bits)
BPHYT_RS07675 ABC transporter for L-Arginine, permease component 2 from Burkholderia phytofirmans PsJN
51% identity, 100% coverage of query (196 bits)
AO356_09905 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
45% identity, 97% coverage of query (185 bits)
TC 3.A.1.3.23 / Q9HU30 Probable permease of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
43% identity, 97% coverage of query (180 bits)
BPHYT_RS24005 L-histidine ABC transporter, permease component 1 from Burkholderia phytofirmans PsJN
38% identity, 90% coverage of query (156 bits)
TC 3.A.1.3.6 / P35118 NocQ aka ATU6026 aka AGR_PTI_66, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
38% identity, 97% coverage of query (150 bits)
ArtQ / b0862 L-arginine ABC transporter membrane subunit ArtQ (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ArtQ / P0AE34 L-arginine ABC transporter membrane subunit ArtQ (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
ARTQ_ECOLI / P0AE34 Arginine ABC transporter permease protein ArtQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P0AE34 Arginine transport system permease protein ArtQ aka B0862, component of Arginine porter from Escherichia coli (see 6 papers)
35% identity, 90% coverage of query (147 bits)
SMc00139 L-lysine ABC transporter, permease component 1 from Sinorhizobium meliloti 1021
36% identity, 96% coverage of query (145 bits)
TC 3.A.1.3.5 / P0A4N5 Octopine transport system permease protein occQ, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
37% identity, 97% coverage of query (144 bits)
PP_3594 L-lysine and D-lysine ABC transporter, permease component 1 from Pseudomonas putida KT2440
37% identity, 98% coverage of query (142 bits)
TcyL / b1918 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
tcyL / P0AFT2 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 3 papers)
TCYL_ECOLI / P0AFT2 L-cystine transport system permease protein TcyL from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P0AFT2 Inner membrane amino-acid ABC transporter permease protein YECS CysY aka B1918, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 4 papers)
31% identity, 95% coverage of query (113 bits)
AO353_21715 ABC transporter for D-glucosamine, permease component 1 from Pseudomonas fluorescens FW300-N2E3
37% identity, 87% coverage of query (110 bits)
Ac3H11_2554 ABC transporter for L-Histidine, permease component 1 from Acidovorax sp. GW101-3H11
33% identity, 94% coverage of query (110 bits)
AO356_00475 ABC transporter for D-Glucosamine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
36% identity, 87% coverage of query (108 bits)
Pf6N2E2_2052 ABC transporter for D-Glucosamine Hydrochloride, permease component 2 from Pseudomonas fluorescens FW300-N2E2
36% identity, 87% coverage of query (107 bits)
Build an alignment for GFF4244 and 23 homologs with ≥ 30% identity
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TCYB_BACSU / P42200 L-cystine transport system permease protein TcyB from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.3.14 / P42200 TcyB (YckJ), component of Uptake system for L-cystine from Bacillus subtilis (see 4 papers)
29% identity, 95% coverage of query (102 bits)
GLNM_BACSU / O34671 Probable glutamine ABC transporter permease protein GlnM from Bacillus subtilis (strain 168) (see paper)
31% identity, 92% coverage of query (97.8 bits)
YXEN_BACSU / P54953 Probable amino-acid permease protein YxeN from Bacillus subtilis (strain 168) (see paper)
36% identity, 77% coverage of query (97.1 bits)
HISM_SALTY / P0A2I7 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
30% identity, 92% coverage of query (96.3 bits)
AO353_21720 ABC transporter for D-glucosamine, permease component 2 from Pseudomonas fluorescens FW300-N2E3
31% identity, 91% coverage of query (95.5 bits)
AO356_00470 ABC transporter for D-Glucosamine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
Pf6N2E2_2051 ABC transporter for D-Glucosamine Hydrochloride, permease component 1 from Pseudomonas fluorescens FW300-N2E2
31% identity, 91% coverage of query (94.4 bits)
ARTQ_BACSU / P54536 Arginine transport system permease protein ArtQ from Bacillus subtilis (strain 168) (see paper)
30% identity, 92% coverage of query (94.4 bits)
HisM / b2307 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
HISM_ECOLI / P0AEU3 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU3 Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
30% identity, 96% coverage of query (94.4 bits)
GlnP / b0810 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnP / P0AEQ6 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.3.2 / P0AEQ6 Glutamine transport system permease protein GlnP aka B0810, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
30% identity, 94% coverage of query (93.2 bits)
TC 3.A.1.3.25 / Q9CES5 Glutamine ABC transporter permease and substrate binding protein protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
30% identity, 91% coverage of query (92.4 bits)
TC 3.A.1.3.6 / P35113 NocM aka ATU6025 aka AGR_PTI_65, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
33% identity, 84% coverage of query (92.4 bits)
TC 3.A.1.3.12 / P73544 BgtB aka GLNH aka SLL1270, component of Arginine/lysine/histidine/glutamine porter (see paper)
32% identity, 85% coverage of query (90.9 bits)
4ymtC / Q8RCC3 Crystal structure of an amino acid abc transporter complex with arginines (see paper)
27% identity, 94% coverage of query (90.1 bits)
4ymwC Crystal structure of an amino acid abc transporter with histidines
27% identity, 94% coverage of query (90.1 bits)
TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
31% identity, 92% coverage of query (89.0 bits)
TC 3.A.1.3.5 / P35114 OCM1 aka OccM, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
31% identity, 86% coverage of query (88.2 bits)
AO356_09910 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
33% identity, 91% coverage of query (88.2 bits)
BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
30% identity, 92% coverage of query (86.7 bits)
GLNP_BACSU / O34606 Probable glutamine ABC transporter permease protein GlnP from Bacillus subtilis (strain 168) (see paper)
32% identity, 96% coverage of query (86.3 bits)
TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
28% identity, 92% coverage of query (85.1 bits)
BPHYT_RS24010 L-histidine ABC transporter, permease component 2 from Burkholderia phytofirmans PsJN
33% identity, 84% coverage of query (85.1 bits)
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Lawrence Berkeley National Laboratory