Searching for up to 100 curated homologs for GFF43 FitnessBrowser__Phaeo:GFF43 (418 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5ti1H / Q144Z1 Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400
    53% identity, 99% coverage of query (426 bits)

FAAA_MOUSE / P35505 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) (see 3 papers)
P35505 fumarylacetoacetase (EC 3.7.1.2) from Mus musculus (see 2 papers)
    48% identity, 94% coverage of query (382 bits)

1hyoB / P35505 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid (see paper)
    48% identity, 95% coverage of query (381 bits)

FAAA_RAT / P25093 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Rattus norvegicus (Rat) (see paper)
    48% identity, 95% coverage of query (381 bits)

2hzyA Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate
    48% identity, 94% coverage of query (381 bits)

1qcoA Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate
    48% identity, 94% coverage of query (381 bits)

FAH_ARATH / Q8RW90 Fumarylacetoacetase; Fumarylacetoacetate hydrolase; AtFAH; Protein SHORT-DAY SENSITIVE CELL DEATH 1; EC 3.7.1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q8RW90 fumarylacetoacetase (EC 3.7.1.2) from Arabidopsis thaliana (see 3 papers)
    47% identity, 98% coverage of query (378 bits)

FAH / P16930 Fumarylacetoacetase (EC 3.7.1.2) from Homo sapiens (see paper)
FAAA_HUMAN / P16930 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) (see 14 papers)
P16930 fumarylacetoacetase (EC 3.7.1.2) from Homo sapiens (see 2 papers)
    48% identity, 94% coverage of query (374 bits)

FAHA_ASPFU / Q4WHT8 Fumarylacetoacetase fahA; Fumarylacetoacetate hydrolase fahA; L-tyrosine degradation gene cluster protein fahA; Pyomelanin biosynthesis cluster protein fahA; EC 3.7.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    47% identity, 98% coverage of query (360 bits)

FAAA_CAEEL / Q94272 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Caenorhabditis elegans (see paper)
Q94272 fumarylacetoacetase (EC 3.7.1.2) from Caenorhabditis elegans (see paper)
    46% identity, 98% coverage of query (349 bits)

GI|2832727 fumarylacetoacetate hydrolase; EC 3.7.1.2 from Emericella nidulans (see 2 papers)
fahA / CAA05043.1 fumarylacetoacetate hydrolase from Aspergillus nidulans (see paper)
    44% identity, 98% coverage of query (343 bits)

FAAA_EMENI / Q00770 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    44% identity, 98% coverage of query (341 bits)

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Build an alignment for GFF43 and 12 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    24% identity, 76% coverage of query (54.7 bits)

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
    24% identity, 76% coverage of query (54.7 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    24% identity, 76% coverage of query (54.7 bits)

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