Searching for up to 100 curated homologs for GFF4359 FitnessBrowser__WCS417:GFF4359 (475 a.a.)
Found high-coverage hits (≥70%) to 24 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ARCD_PSEAE / P18275 Arginine/ornithine antiporter; Arginine-ornithine exchanger from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
TC 2.A.3.2.3 / P18275 Arginine:ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
arcD / GB|AAG08555.1 arginine/ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
74% identity, 100% coverage of query (633 bits)
YdgI / b1605 putative arginine:ornithine antiporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ARCD_ECOLI / P0AAE5 Putative arginine/ornithine antiporter from Escherichia coli (strain K12) (see paper)
46% identity, 92% coverage of query (380 bits)
TC 2.A.3.2.4 / P35865 Lysine permease from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
lysI / RF|YP_225261.1 L-lysine transport protein from Corynebacterium glutamicum (see paper)
46% identity, 99% coverage of query (376 bits)
arcD / CAA04686.1 arginine /ornithine antiporter from Lactobacillus sakei (see 2 papers)
40% identity, 94% coverage of query (334 bits)
AAXC_CHLPN / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see paper)
TC 2.A.3.2.7 / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (see 4 papers)
41% identity, 95% coverage of query (328 bits)
TC 2.A.3.2.11 / F2HL56 Arginine/Ornithine antiporter of 526 aas and 14 TMSs from Lactococcus lactis subsp. lactis (strain CV56)
36% identity, 100% coverage of query (308 bits)
ARCD1_LACLM / A2RNI5 Arginine/ornithine antiporter ArcD1; Arginine/ornithine exchanger from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
36% identity, 100% coverage of query (308 bits)
TC 2.A.3.2.10 / F2HL52 Arginine/Ornithine antiporter of 497 aas and 13 TMSs, ArcD2 from Lactococcus lactis subsp. lactis (strain CV56)
35% identity, 97% coverage of query (283 bits)
ARCD2_LACLM / A2RNI1 Arginine/ornithine antiporter ArcD2; Arginine/ornithine exchanger from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
37% identity, 93% coverage of query (276 bits)
Build an alignment for GFF4359 and 9 homologs with ≥ 30% identity
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ADIC_SALTY / P60066 Arginine/agmatine antiporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
28% identity, 88% coverage of query (139 bits)
5j4nA / P60061 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution (see paper)
28% identity, 88% coverage of query (133 bits)
YjdD / b4115 arginine:agmatine antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
adiC / P60061 arginine:agmatine antiporter from Escherichia coli (strain K12) (see 2 papers)
ADIC_ECOLI / P60061 Arginine/agmatine antiporter from Escherichia coli (strain K12) (see 6 papers)
ADIC_ECO57 / P60063 Arginine/agmatine antiporter from Escherichia coli O157:H7 (see 3 papers)
TC 2.A.3.2.5 / P60061 Homodimeric electrogenic arginine (Km=80μM):agmatine antiporter, AdiC, involved in extreme acid resistance (Fang et al., 2007; Gong et al., 2003; Iyer et al., 2003). A projection structure at 6.5 Å resolution has been published (Casagrande et al., 2008), and the 3.2 Å resolution X-ray structure was determined by Fang et al., 2009 and Gao et al., 2009 from Escherichia coli (see 6 papers)
adiC / GB|AAN45533.1 arginine/agmatine antiporter from Shigella flexneri (see 6 papers)
28% identity, 88% coverage of query (133 bits)
3l1lA Structure of arg-bound escherichia coli adic
27% identity, 88% coverage of query (130 bits)
PotE / b0692 putrescine transporter PotE from Escherichia coli K-12 substr. MG1655 (see 13 papers)
potE / P0AAF1 putrescine transporter PotE from Escherichia coli (strain K12) (see 14 papers)
POTE_ECOLI / P0AAF1 Putrescine transporter PotE; Putrescine-proton symporter / putrescine-ornithine antiporter from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.3.2.1 / P0AAF1 Putrescine:ornithine antiporter for putrescine export; putrescine:H+ symporter for uptake from Escherichia coli (see 5 papers)
25% identity, 92% coverage of query (98.2 bits)
CadB / b4132 lysine:cadaverine antiporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
CadB / P0AAE8 lysine:cadaverine antiporter from Escherichia coli (strain K12) (see 12 papers)
CADB_ECOLI / P0AAE8 Cadaverine/lysine antiporter from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.2.2 / P0AAE8 Cadaverine:lysine antiporter [Catalyzes cadaverine uptake via H+ symport (Km=21μM) and cadaverine export (Km=300 μM) via cadaverine:lysine antiport.] (Soksawatmaekhin et al., 2004). Modeling tools have been used to gain information about the structures and functions of CadB and PotE in E. coli from Escherichia coli (see 6 papers)
26% identity, 80% coverage of query (90.5 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
25% identity, 80% coverage of query (70.9 bits)
CAAT3_ARATH / Q8GYB4 Cationic amino acid transporter 3, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 83% coverage of query (65.5 bits)
CAAT1_ARATH / Q84MA5 Cationic amino acid transporter 1; Amino acid transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 71% coverage of query (56.6 bits)
CCNA_00435 L-proline transporter from Caulobacter crescentus NA1000
25% identity, 72% coverage of query (55.8 bits)
S7A13_HUMAN / Q8TCU3 Solute carrier family 7 member 13; Sodium-independent aspartate/glutamate transporter 1; X-amino acid transporter 2 from Homo sapiens (Human) (see paper)
TC 2.A.3.8.24 / Q8TCU3 Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2) from Homo sapiens (see 3 papers)
24% identity, 75% coverage of query (49.3 bits)
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
22% identity, 71% coverage of query (49.3 bits)
S7A13_MOUSE / Q91WN3 Solute carrier family 7 member 13; Sodium-independent aspartate/glutamate transporter 1; X-amino acid transporter 2 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.3.8.8 / Q91WN3 Aspartate/glutamate Na+-independent transporter, AGT1 from Mus musculus (Mouse) (see 5 papers)
24% identity, 75% coverage of query (48.9 bits)
TC 2.A.3.8.9 / Q19834 Heteromeric amino acid transporter #1 (transports most neutral aas with highest rates for Ala and Ser (Km≈100 μM)). They function by obligatory aa:aa exchange (Veljkovic et al., 2004b) (see paper)
24% identity, 76% coverage of query (48.1 bits)
CadR / b2156 lysine:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 15 papers)
lysP / P25737 lysine:H+ symporter from Escherichia coli (strain K12) (see 13 papers)
LYSP_ECOLI / P25737 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.2 / P25737 Lysine:H+ symporter. Forms a stable complex with CadC to allow lysine-dependent adaptation to acidic stress (Rauschmeier et al. 2013). The Salmonella orthologue is 95% identical to the E. coli protein and is highly specific for Lysine. Residues involved in lysine binding have been identified from Escherichia coli (see 5 papers)
lysP lysine-specific permease from Escherichia coli K12 (see 5 papers)
23% identity, 73% coverage of query (44.7 bits)
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Lawrence Berkeley National Laboratory