Searching for up to 100 curated homologs for GFF4515 FitnessBrowser__WCS417:GFF4515 (559 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

leuA / CAA50295.1 2-isopropylmalate synthase from Corynebacterium glutamicum (see paper)
    55% identity, 97% coverage of query (620 bits)

LEU1_CORGL / P42455 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    55% identity, 97% coverage of query (620 bits)

LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis (see 6 papers)
    51% identity, 97% coverage of query (590 bits)

3figB / P9WQB3 Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
    53% identity, 97% coverage of query (586 bits)

3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
    53% identity, 97% coverage of query (586 bits)

3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
    53% identity, 97% coverage of query (585 bits)

1sr9A Crystal structure of leua from mycobacterium tuberculosis
    53% identity, 97% coverage of query (585 bits)

CH_124190 2-isopropylmalate synthase 2 from Magnaporthe grisea 70-15 (see paper)
    52% identity, 98% coverage of query (583 bits)

3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
    53% identity, 97% coverage of query (582 bits)

LEU4 putative 2-isopropylmalalate synthase from Candida albicans (see paper)
    51% identity, 99% coverage of query (572 bits)

LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    52% identity, 98% coverage of query (565 bits)

LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    50% identity, 98% coverage of query (559 bits)

GLOH_GLAL2 / S3D9F8 Isopropyl malate synthase gloH; L-homotyrosine biosynthesis sub-cluster protein gloH; Pneumocandin biosynthesis cluster protein H; EC 2.3.3.13 from Glarea lozoyensis (strain ATCC 20868 / MF5171) (see 5 papers)
    45% identity, 75% coverage of query (401 bits)

HtyA / K0E4E5 2-(4-hydroxybenzyl)-malate synthase from Aspergillus rugulosus (see paper)
HTYA_ASPRU / K0E4E5 Isopropyl malate synthase htyA; L-homotyrosine biosynthetic cluster protein A; EC 2.3.3.13 from Aspergillus rugulosus (Emericella rugulosa) (see paper)
    40% identity, 97% coverage of query (394 bits)

AMT7_ALTAL / C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    44% identity, 78% coverage of query (375 bits)

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Build an alignment for GFF4515 and 15 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
    27% identity, 92% coverage of query (132 bits)

K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
    27% identity, 99% coverage of query (132 bits)

LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
    27% identity, 93% coverage of query (128 bits)

Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
    26% identity, 92% coverage of query (128 bits)

LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
    27% identity, 93% coverage of query (122 bits)

BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
    26% identity, 91% coverage of query (120 bits)

Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
    28% identity, 91% coverage of query (119 bits)

Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
    28% identity, 92% coverage of query (119 bits)

LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
    24% identity, 92% coverage of query (117 bits)

Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
    26% identity, 92% coverage of query (110 bits)

D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
    26% identity, 92% coverage of query (110 bits)

LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
    25% identity, 93% coverage of query (105 bits)

LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
    24% identity, 97% coverage of query (103 bits)

LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida) (see paper)
    25% identity, 93% coverage of query (103 bits)

LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
    24% identity, 93% coverage of query (102 bits)

cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
    22% identity, 92% coverage of query (66.2 bits)

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