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Searching for up to 100 curated homologs for GFF4621 FitnessBrowser__WCS417:GFF4621 (468 a.a.)

Found high-coverage hits (≥70%) to 64 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AO353_05930 L-tryptophan transporter from Pseudomonas fluorescens FW300-N2E3
    89% identity, 98% coverage of query (815 bits)

GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
    37% identity, 98% coverage of query (314 bits)

gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
    37% identity, 98% coverage of query (314 bits)

AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
    38% identity, 95% coverage of query (313 bits)

AO356_17670 L-alanine and D-alanine permease from Pseudomonas fluorescens FW300-N2C3
    41% identity, 93% coverage of query (311 bits)

PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
    37% identity, 91% coverage of query (305 bits)

AO353_16120 D-alanine and L-alanine transporter from Pseudomonas fluorescens FW300-N2E3
    41% identity, 93% coverage of query (304 bits)

MmuP / b0260 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
mmuP / Q47689 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.1.10 / Q47689 S-Methylmethionine permease, MmuP from Escherichia coli (see 3 papers)
    37% identity, 95% coverage of query (303 bits)

PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
    40% identity, 96% coverage of query (303 bits)

RR42_RS28305 L-threonine:H+ symporter from Cupriavidus basilensis FW507-4G11
    36% identity, 96% coverage of query (301 bits)

PfGW456L13_4291 L-tryptophan transporter from Pseudomonas fluorescens GW456-L13
    38% identity, 98% coverage of query (299 bits)

RR42_RS33495 L-phenylalanine:H+ symporter AroP from Cupriavidus basilensis FW507-4G11
    36% identity, 97% coverage of query (296 bits)

ROCE_BACSU / P39137 Amino-acid permease RocE from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.1.11 / P39137 L-Arginine permease, RocE from Bacillus subtilis (see 3 papers)
    36% identity, 99% coverage of query (295 bits)

AO353_12275 histidine permease from Pseudomonas fluorescens FW300-N2E3
    35% identity, 96% coverage of query (285 bits)

H281DRAFT_04042 phenylacetate transporter from Paraburkholderia bryophila 376MFSha3.1
    37% identity, 89% coverage of query (285 bits)

TC 2.A.3.1.6 / P37460 Proline-specific permease (ProY) from Salmonella typhimurium (see 2 papers)
    34% identity, 96% coverage of query (277 bits)

YifK / b3795 putative transporter YifK from Escherichia coli K-12 substr. MG1655 (see 5 papers)
thrP / P27837 threonine/serine:H+ symporter ThrP from Escherichia coli (strain K12) (see 5 papers)
    34% identity, 95% coverage of query (276 bits)

AO356_18530 L-tyrosine transporter from Pseudomonas fluorescens FW300-N2C3
    36% identity, 95% coverage of query (275 bits)

YajM / b0402 putative transporter ProY from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 2.A.3.1.23 / P0AAE2 ProY of 457 aas and 12 TMSs from Escherichia coli (strain K12)
    35% identity, 96% coverage of query (271 bits)

YVBW_BACSU / O32257 Uncharacterized amino acid permease YvbW from Bacillus subtilis (strain 168)
    35% identity, 94% coverage of query (259 bits)

LYSP_LACLM / A2RNZ6 Lysine-specific permease LysP; Lysine transporter LysP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    36% identity, 96% coverage of query (257 bits)

YBXG_BACSU / P54425 Probable threonine/serine transporter YbxG from Bacillus subtilis (strain 168) (see paper)
    34% identity, 95% coverage of query (255 bits)

TC 2.A.3.1.18 / K7VV21 The lysine specific transporter, LysP of 488 aas and 12 TMSs from Lactococcus lactis subsp. cremoris UC509.9
    35% identity, 96% coverage of query (254 bits)

DagA / b4208 D-serine/alanine/glycine/:H+symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
cycA / P0AAE0 D-serine/alanine/glycine:H+symporter from Escherichia coli (strain K12) (see 15 papers)
CYCA_ECOLI / P0AAE0 D-serine/D-alanine/glycine transporter; Amino acid carrier CycA from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.7 / P0AAE0 D-Serine/D-alanine/glycine/D-cycloserine:H+ symporter from Escherichia coli (see 4 papers)
    34% identity, 82% coverage of query (251 bits)

YncF / b1453 L-asparagine transporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ANSP_ECOLI / P77610 L-asparagine permease; L-asparagine transport protein from Escherichia coli (strain K12) (see paper)
TC 2.A.3.1.24 / P77610 Asparagine transporter of 499 aas and 12 TMSs, 91% identical to the orthologue in Salmonella enterica (2.A.3.1.8) from Escherichia coli (strain K12)
    34% identity, 85% coverage of query (245 bits)

CYCA_ECOL6 / A0A0H2VDI7 D-serine/D-alanine/glycine transporter from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 2 papers)
    34% identity, 82% coverage of query (243 bits)

TC 2.A.3.1.8 / P40812 Asparagine permease (AnsP) of 497 aas and 12 TMSs from Salmonella typhimurium (see 2 papers)
ansP / AAA80001.1 L-asparagine permease from Salmonella enterica (see paper)
    34% identity, 85% coverage of query (243 bits)

CadR / b2156 lysine:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 15 papers)
lysP / P25737 lysine:H+ symporter from Escherichia coli (strain K12) (see 13 papers)
LYSP_ECOLI / P25737 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.2 / P25737 Lysine:H+ symporter. Forms a stable complex with CadC to allow lysine-dependent adaptation to acidic stress (Rauschmeier et al. 2013). The Salmonella orthologue is 95% identical to the E. coli protein and is highly specific for Lysine. Residues involved in lysine binding have been identified from Escherichia coli (see 5 papers)
lysP lysine-specific permease from Escherichia coli K12 (see 5 papers)
    32% identity, 93% coverage of query (236 bits)

ANSP2_MYCTU / P9WQM7 L-asparagine permease 2; L-asparagine transport protein 2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    32% identity, 94% coverage of query (234 bits)

GabP / b2663 4-aminobutanoate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 11 papers)
gabP / P25527 4-aminobutanoate:H+ symporter from Escherichia coli (strain K12) (see 10 papers)
GABP_ECOLI / P25527 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate carrier; 4-aminobutyrate permease; Gamma-aminobutyrate permease from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.4 / P25527 γ-aminobutyrate:H+ symporter, GabP. It also transports a variety of pyridine carboxylates. Phosphatidylethanolamine is required for its proper topological organization(Zhang et al. 2005) from Escherichia coli (see 5 papers)
    32% identity, 89% coverage of query (230 bits)

TC 2.A.3.1.17 / M1IW84 D-serine/L-alanine/D-alanine/glycine/D-cycloserine uptake porter of 556 aas, CycA from Mycobacterium bovis BCG str. Korea 1168P
    36% identity, 84% coverage of query (226 bits)

AROP_CORGL / Q46065 Aromatic amino acid transport protein AroP; General aromatic amino acid permease from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 2.A.3.1.12 / Q46065 Aromatic amino acid permease, AroP from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
    35% identity, 80% coverage of query (223 bits)

HISP_LACLM / A2RI97 Histidine permease HisP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    30% identity, 95% coverage of query (221 bits)

agtA amino acid transporter from Emericella nidulans (see 2 papers)
    32% identity, 85% coverage of query (209 bits)

GAP1_CANAL / Q5AG77 Amino-acid permease GAP1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 9 papers)
TC 2.A.3.10.23 / Q5AG77 Amino acid permease, GAP1. Transports Arg, Met, Leu and Phe from Candida albicans (see 2 papers)
GAP1 general amino acid permease from Candida albicans (see 3 papers)
    34% identity, 84% coverage of query (208 bits)

BAUD_PSEAE / Q9I703 Probable GABA permease; 4-amino butyrate transport carrier; Gamma-aminobutyrate permease from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    33% identity, 86% coverage of query (204 bits)

TC 2.A.3.1.20 / F2HQ24 Serine transporter, SerP2 or YdgB, of 459 aas and 12 TMSs (Trip et al. 2013). Transports L-alanine (Km = 20 μM), D-alanine (Km = 38 μM), L-serine, D-serine (Km = 356 μM) and glycine (Noens and Lolkema 2015). The encoding gene is adjacent to the one encoding SerP1 (TC# 2.A.3.1.21) from Lactococcus lactis subsp. lactis (strain CV56)
    33% identity, 81% coverage of query (203 bits)

GAP3_CANAL / A0A1D8PN88 Amino-acid permease GAP3 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 5 papers)
    30% identity, 89% coverage of query (202 bits)

GAP4_CANAL / Q59WB3 S-adenosylmethionine permease GAP4; SAM permease; Amino-acid permease GAP4 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 6 papers)
TC 2.A.3.10.25 / Q59WB3 Arginine transporter, GAP4 from Candida albicans (see paper)
GAP4 potential general amino acid permease from Candida albicans (see paper)
    37% identity, 80% coverage of query (201 bits)

SERP2_LACLM / A2RI86 DL-alanine permease SerP2 from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
    32% identity, 81% coverage of query (201 bits)

TC 2.A.3.1.21 / F2HQ25 Serine uptake transporter, SerP1, of 259 aas and 12 TMSs (Trip et al. 2013). L-serine is the highest affinity substrate (Km = 18 μM), but SerP1 also transports L-threonine and L-cysteine (Km values = 20 - 40 μM) from Lactococcus lactis subsp. lactis (strain CV56)
    32% identity, 83% coverage of query (200 bits)

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Build an alignment for GFF4621 and 41 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

LYP1_YEAST / P32487 Lysine-specific permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
TC 2.A.3.10.10 / P32487 Lysine permease of 611 aas and 13 putative TMSs, Lyp1 from Saccharomyces cerevisiae (Baker's yeast) (see 9 papers)
LYP1 / GI|1302328 lysine-specific permease from Saccharomyces cerevisiae
    29% identity, 88% coverage of query (197 bits)

SERP1_LACLM / A2RI87 Serine permease SerP1 from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
    32% identity, 83% coverage of query (196 bits)

TC 2.A.3.10.28 / O60170 Probable amino-acid permease Meu22 (Meiotic expression up-regulated protein 22) from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (see 2 papers)
    31% identity, 86% coverage of query (196 bits)

CAN1_YEAST / P04817 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 12 papers)
TC 2.A.3.10.4 / P04817 Arginine permease from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
CAN1 / RF|NP_010851.1 arginine permease from Saccharomyces cerevisiae
    29% identity, 91% coverage of query (195 bits)

PUT4_YEAST / P15380 Proline-specific permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.3.10.3 / P15380 Proline permease from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
PUT4 / RF|NP_014993.1 proline-specific permease from Saccharomyces cerevisiae
    31% identity, 88% coverage of query (191 bits)

DIP5_YEAST / P53388 Dicarboxylic amino acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
TC 2.A.3.10.13 / P53388 Dicarboxylic amino acid permease from Saccharomyces cerevisiae (Baker's yeast) (see 7 papers)
DIP5 / RF|NP_015058.1 dicarboxylic amino acid permease from Saccharomyces cerevisiae
    32% identity, 84% coverage of query (188 bits)

CAN1_CANAL / A0A1D8PPI5 Lysine/arginine permease CAN1; Basic amino acids permease CAN1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
    31% identity, 89% coverage of query (187 bits)

TC 2.A.3.10.20 / P43059 The high affinity basic amino acid (Arg, Lys, His) transporter, Can1 from Candida albicans (Yeast) (see paper)
    31% identity, 89% coverage of query (187 bits)

YQD2_SCHPO / Q9C0V0 Probable amino-acid permease PB1C11.02 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 81% coverage of query (186 bits)

GAP5_CANAL / A0A1D8PMB1 Amino-acid permease GAP5 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
    30% identity, 91% coverage of query (185 bits)

GAP2_CANAL / A0A1D8PK89 General amino-acid permease GAP2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 6 papers)
TC 2.A.3.10.24 / Q59YT0 General amino and permease and transceptor, GAP2. Transports all amino acids including citruline and eight tested toxic amino acid derivatives from Candida albicans (see paper)
    32% identity, 82% coverage of query (182 bits)

CAT1_SCHPO / Q9URZ4 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    32% identity, 81% coverage of query (182 bits)

TC 2.A.3.10.21 / Q9URZ4 The basic amino acid (canavanine sensitivity) transporter, Cat1 from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
cat1 / RF|NP_595008.2 uncharacterized amino-acid permease C869.11 from Schizosaccharomyces pombe (see 3 papers)
    32% identity, 81% coverage of query (181 bits)

CAN1_CANGA / Q6FNY1 Arginine permease CAN1 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see paper)
    29% identity, 85% coverage of query (181 bits)

GNP1_YEAST / P48813 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
TC 2.A.3.10.5 / P48813 High affinity glutamine permease from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
GNP1 / GI|927778 high-affinity glutamine permease from Saccharomyces cerevisiae
    29% identity, 83% coverage of query (167 bits)

GAP1_YEAST / P19145 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 19 papers)
TC 2.A.3.10.2 / P19145 General amino acid permease (all L-amino acids and some D-amino acids as well as β-alanine, polyamines and GABA) from Saccharomyces cerevisiae (Baker's yeast) (see 8 papers)
GAP1 / RF|NP_012965.1 general amino-acid permease GAP1 from Saccharomyces cerevisiae
    29% identity, 89% coverage of query (156 bits)

SSY1_YEAST / Q03770 SPS-sensor component SSY1; Amino-acid permease homolog SSY1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
TC 2.A.3.10.12 / Q03770 Leucine sensor/transcription factor. Mutants hyper- and hyposensitive to inducer (Poulsen et al., 2008) suggest a sensor mechanism involving outward and inward facing conformations from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
SSY1 / RF|NP_010444.1 amino-acid permease SSY1 from Saccharomyces cerevisiae (see paper)
    22% identity, 71% coverage of query (73.9 bits)

STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
    24% identity, 98% coverage of query (61.6 bits)

CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
    20% identity, 85% coverage of query (53.5 bits)

6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
    22% identity, 94% coverage of query (49.3 bits)

5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
    22% identity, 94% coverage of query (48.9 bits)

PotE / b0692 putrescine transporter PotE from Escherichia coli K-12 substr. MG1655 (see 13 papers)
potE / P0AAF1 putrescine transporter PotE from Escherichia coli (strain K12) (see 14 papers)
POTE_ECOLI / P0AAF1 Putrescine transporter PotE; Putrescine-proton symporter / putrescine-ornithine antiporter from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.3.2.1 / P0AAF1 Putrescine:ornithine antiporter for putrescine export; putrescine:H+ symporter for uptake from Escherichia coli (see 5 papers)
    22% identity, 71% coverage of query (45.1 bits)

6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
    22% identity, 83% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory