Searching for up to 100 curated homologs for GFF5095 FitnessBrowser__WCS417:GFF5095 (239 a.a.)
Found high-coverage hits (≥70%) to 39 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PP_3594 L-lysine and D-lysine ABC transporter, permease component 1 from Pseudomonas putida KT2440
79% identity, 100% coverage of query (372 bits)
SMc00139 L-lysine ABC transporter, permease component 1 from Sinorhizobium meliloti 1021
52% identity, 96% coverage of query (239 bits)
BPHYT_RS24005 L-histidine ABC transporter, permease component 1 from Burkholderia phytofirmans PsJN
37% identity, 95% coverage of query (155 bits)
hisQ / b2308 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisQ (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
HISQ_ECOLI / P52094 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P52094 Histidine transport system permease protein HisQ, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
38% identity, 91% coverage of query (150 bits)
HISQ_SALTY / P0A2I9 Histidine/lysine/arginine/ornithine transport system permease protein HisQ from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I9 Histidine transport system permease protein HisQ aka STM2353, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
37% identity, 91% coverage of query (145 bits)
AO353_03050 ABC transporter for L-Arginine and L-Citrulline, permease component 2 from Pseudomonas fluorescens FW300-N2E3
35% identity, 91% coverage of query (145 bits)
TC 3.A.1.3.6 / P35118 NocQ aka ATU6026 aka AGR_PTI_66, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
36% identity, 96% coverage of query (142 bits)
AO356_18705 L-Arginine ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N2C3
35% identity, 91% coverage of query (142 bits)
PS417_21740 ABC transporter for L-Arginine, permease component 1 from Pseudomonas simiae WCS417
35% identity, 91% coverage of query (142 bits)
Pf6N2E2_5661 L-Arginine ABC transporter, permease protein AotQ from Pseudomonas fluorescens FW300-N2E2
34% identity, 91% coverage of query (140 bits)
Pf1N1B4_3432 ABC transporter for L-Arginine and L-Citrulline, permease component 1 from Pseudomonas fluorescens FW300-N1B4
34% identity, 91% coverage of query (139 bits)
AO356_09905 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
42% identity, 92% coverage of query (138 bits)
TC 3.A.1.3.23 / Q9HU30 Probable permease of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
41% identity, 92% coverage of query (137 bits)
TC 3.A.1.3.11 / O50182 AotQ, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa (see paper)
aotQ / GI|2668596 arginine/ornithine transport protein from Pseudomonas aeruginosa (see paper)
36% identity, 80% coverage of query (127 bits)
TC 3.A.1.3.5 / P0A4N5 Octopine transport system permease protein occQ, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
34% identity, 95% coverage of query (127 bits)
Pf6N2E2_2959 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2E2
36% identity, 97% coverage of query (122 bits)
ArtQ / b0862 L-arginine ABC transporter membrane subunit ArtQ (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ArtQ / P0AE34 L-arginine ABC transporter membrane subunit ArtQ (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
ARTQ_ECOLI / P0AE34 Arginine ABC transporter permease protein ArtQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P0AE34 Arginine transport system permease protein ArtQ aka B0862, component of Arginine porter from Escherichia coli (see 6 papers)
35% identity, 90% coverage of query (122 bits)
AO356_05500 ABC transporter for L-Lysine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
35% identity, 97% coverage of query (122 bits)
TcyL / b1918 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
tcyL / P0AFT2 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 3 papers)
TCYL_ECOLI / P0AFT2 L-cystine transport system permease protein TcyL from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P0AFT2 Inner membrane amino-acid ABC transporter permease protein YECS CysY aka B1918, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 4 papers)
35% identity, 92% coverage of query (118 bits)
BPHYT_RS07675 ABC transporter for L-Arginine, permease component 2 from Burkholderia phytofirmans PsJN
34% identity, 92% coverage of query (112 bits)
TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
37% identity, 89% coverage of query (110 bits)
TC 3.A.1.3.12 / P73544 BgtB aka GLNH aka SLL1270, component of Arginine/lysine/histidine/glutamine porter (see paper)
34% identity, 89% coverage of query (109 bits)
TCYB_BACSU / P42200 L-cystine transport system permease protein TcyB from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.3.14 / P42200 TcyB (YckJ), component of Uptake system for L-cystine from Bacillus subtilis (see 4 papers)
35% identity, 89% coverage of query (108 bits)
SMc02120 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, permease component 2 from Sinorhizobium meliloti 1021
36% identity, 93% coverage of query (107 bits)
TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
33% identity, 90% coverage of query (103 bits)
Ac3H11_2554 ABC transporter for L-Histidine, permease component 1 from Acidovorax sp. GW101-3H11
32% identity, 87% coverage of query (101 bits)
BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
30% identity, 90% coverage of query (95.1 bits)
ARTQ_BACSU / P54536 Arginine transport system permease protein ArtQ from Bacillus subtilis (strain 168) (see paper)
32% identity, 77% coverage of query (94.4 bits)
TC 3.A.1.3.25 / Q9CES5 Glutamine ABC transporter permease and substrate binding protein protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
34% identity, 73% coverage of query (93.6 bits)
SMc00138 L-lysine ABC transporter, permease component 2 from Sinorhizobium meliloti 1021
33% identity, 92% coverage of query (93.2 bits)
4ymtC / Q8RCC3 Crystal structure of an amino acid abc transporter complex with arginines (see paper)
30% identity, 80% coverage of query (91.7 bits)
4ymwC Crystal structure of an amino acid abc transporter with histidines
30% identity, 80% coverage of query (91.3 bits)
AO356_09910 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
34% identity, 90% coverage of query (88.6 bits)
TC 3.A.1.3.8 / Q52814 AapM, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapM / CAA57935.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
31% identity, 92% coverage of query (88.6 bits)
TC 3.A.1.3.5 / P35114 OCM1 aka OccM, component of Octopine porter from Agrobacterium tumefaciens (see 2 papers)
31% identity, 88% coverage of query (88.2 bits)
TC 3.A.1.3.6 / P35113 NocM aka ATU6025 aka AGR_PTI_65, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
31% identity, 90% coverage of query (87.8 bits)
Pf6N2E2_5404 ABC transporter for D-Alanine, permease component 1 from Pseudomonas fluorescens FW300-N2E2
31% identity, 95% coverage of query (85.9 bits)
YhdY / b3270 putative ABC transporter membrane subunit YhdY from Escherichia coli K-12 substr. MG1655 (see 5 papers)
32% identity, 87% coverage of query (82.0 bits)
Build an alignment for GFF5095 and 38 homologs with ≥ 30% identity
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HISM_SALTY / P0A2I7 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
27% identity, 89% coverage of query (80.1 bits)
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Lawrence Berkeley National Laboratory