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Searching for up to 100 curated homologs for GFF5417 FitnessBrowser__WCS417:GFF5417 (474 a.a.)

Found high-coverage hits (≥70%) to 79 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YjiR / b4340 fused putative DNA-binding transcriptional regulator/putative aminotransferase YjiR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
yjiR / RF|NP_418760 uncharacterized HTH-type transcriptional regulator yjiR from Escherichia coli K12 (see 2 papers)
    57% identity, 99% coverage of query (560 bits)

DVU0030 / VIMSS7650531 DVU0030 regulator of Amino acid transport from Desulfovibrio magneticus RS-1
    36% identity, 99% coverage of query (317 bits)

DVU0030 / VIMSS8508254 DVU0030 regulator of Amino acid transport from Desulfovibrio salexigens DSM 2638
    36% identity, 97% coverage of query (313 bits)

YdcR / b1439 fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydcR / MB|P77730 uncharacterized HTH-type transcriptional regulator ydcR from Escherichia coli K12 (see 3 papers)
    36% identity, 97% coverage of query (305 bits)

DVU0030 / VIMSS8501445 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris str. Miyazaki F
    37% identity, 95% coverage of query (292 bits)

DVU0030 / VIMSS7454265 DVU0030 regulator of Amino acid transport from Desulfohalobium retbaense DSM 5692
    37% identity, 97% coverage of query (285 bits)

DVU0030 / VIMSS7533539 DVU0030 regulator of Amino acid transport from Desulfomicrobium baculatum DSM 4028
    35% identity, 99% coverage of query (283 bits)

DVU0030 / VIMSS393253 DVU0030 regulator of Amino acid transport from Desulfovibrio desulfuricans G20
    35% identity, 95% coverage of query (275 bits)

DVU0030 / VIMSS408289 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris Hildenborough
    36% identity, 97% coverage of query (275 bits)

O57946 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Pyrococcus horikoshii (see paper)
    31% identity, 79% coverage of query (204 bits)

3aovA / O57946 Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with plp
    31% identity, 79% coverage of query (204 bits)

3wx9A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, gla, 4ad, 2og, glu and kya
    31% identity, 79% coverage of query (204 bits)

3av7A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, kyn as substrates and kya as products
    31% identity, 79% coverage of query (204 bits)

3aowC Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with akg
    31% identity, 79% coverage of query (204 bits)

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp. (see paper)
    32% identity, 78% coverage of query (200 bits)

ARAT1_THELN / H3ZPL1 Aromatic-amino-acid aminotransferase 1; ARAT-I; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    31% identity, 78% coverage of query (196 bits)

Build an alignment

Build an alignment for GFF5417 and 16 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

YdfD/YisV / VIMSS6924547 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Paenibacillus sp. JDR-2
    29% identity, 97% coverage of query (195 bits)

AZOBR_RS06555 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Azospirillum brasilense Sp245
    31% identity, 78% coverage of query (184 bits)

1wstA / Q9V2W5 Crystal structure of multiple substrate aminotransferase (msat) from thermococcus profundus
    30% identity, 79% coverage of query (171 bits)

2zc0A / Q9C4M4 Crystal structure of an archaeal alanine:glyoxylate aminotransferase (see paper)
    30% identity, 75% coverage of query (160 bits)

NORG_STAA8 / Q2G1P1 HTH-type transcriptional regulator NorG from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    25% identity, 92% coverage of query (159 bits)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus (see paper)
2zyjA / Q72LL6 Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-glutamate), from thermus thermophilus hb27 (see paper)
    30% identity, 80% coverage of query (153 bits)

lysN / Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    30% identity, 80% coverage of query (153 bits)

YdfD/YisV / VIMSS63013 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus halodurans C-125
    27% identity, 99% coverage of query (153 bits)

3cbfA Crystal structure of lysn, alpha-aminoadipate aminotransferase, from thermus thermophilus hb27
    30% identity, 80% coverage of query (153 bits)

2egyA Crystal structure of lysn, alpha-aminoadipate aminotransferase (substrate free form), from thermus thermophilus hb27
    30% identity, 80% coverage of query (153 bits)

Ac3H11_1015 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Acidovorax sp. GW101-3H11
    28% identity, 78% coverage of query (150 bits)

YdfD/YisV / VIMSS822665 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus clausii KSM-K16
    27% identity, 99% coverage of query (150 bits)

2z1yA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-leucine), from thermus thermophilus hb27
    30% identity, 77% coverage of query (149 bits)

BWI76_RS24235 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Klebsiella michiganensis M5al
    28% identity, 78% coverage of query (145 bits)

1vp4A / Q9X0L5 Crystal structure of a putative aminotransferase (tm1131) from thermotoga maritima msb8 at 1.82 a resolution
    25% identity, 77% coverage of query (139 bits)

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
    28% identity, 74% coverage of query (132 bits)

Aadat / Q64602 α-aminoadipate aminotransferase subunit (EC 2.6.1.39) from Rattus norvegicus (see paper)
AADAT_RAT / Q64602 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Rattus norvegicus (Rat) (see paper)
Q64602 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus (see 2 papers)
    28% identity, 72% coverage of query (132 bits)

PdxR / VIMSS5804477 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus equi subsp. zooepidemicus MGCS10565
    27% identity, 84% coverage of query (117 bits)

TAUR_RHOCB / D5AKX9 HTH-type transcriptional regulator TauR from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    26% identity, 98% coverage of query (117 bits)

1v2eA / Q75WK2 Crystal structure of t.Th hb8 glutamine aminotransferase complex with a-keto-g-methylthiobutyrate (see paper)
    29% identity, 76% coverage of query (109 bits)

1v2fA Crystal structure of t.Th hb8 glutamine aminotransferase complex with 3-phenylpropionate
    29% identity, 76% coverage of query (109 bits)

BAD06364.1 aminotransferase from Thermus thermophilus (see paper)
    29% identity, 76% coverage of query (108 bits)

PdxR / VIMSS10395811 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus gallolyticus UCN34
    28% identity, 75% coverage of query (104 bits)

aruH / Q9HUI9 L-arginine:pyruvate transaminase subunit (EC 2.6.1.84) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
ARUH_PSEAE / Q9HUI9 Arginine--pyruvate transaminase AruH; EC 2.6.1.84 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HUI9 arginine-pyruvate transaminase (EC 2.6.1.84) from Pseudomonas aeruginosa (see paper)
    28% identity, 81% coverage of query (103 bits)

O59096 aromatic-amino-acid transaminase (EC 2.6.1.57) from Pyrococcus horikoshii (see paper)
    27% identity, 76% coverage of query (101 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    27% identity, 76% coverage of query (101 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    27% identity, 76% coverage of query (101 bits)

PdxR / VIMSS3789276 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus gordonii str. Challis substr. CH1
    26% identity, 79% coverage of query (100 bits)

Desal_3745 / VIMSS8508801 Desal_3745 regulator of Metabolite transport from Desulfovibrio salexigens DSM 2638
    24% identity, 91% coverage of query (98.6 bits)

GABR_BACSU / P94426 HTH-type transcriptional regulatory protein GabR from Bacillus subtilis (strain 168) (see 2 papers)
    27% identity, 80% coverage of query (98.6 bits)

P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    23% identity, 80% coverage of query (95.9 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    27% identity, 75% coverage of query (93.2 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    27% identity, 75% coverage of query (93.2 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    27% identity, 75% coverage of query (93.2 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    27% identity, 75% coverage of query (92.8 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    27% identity, 75% coverage of query (92.8 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    27% identity, 75% coverage of query (92.8 bits)

7zlaB / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the half-closed conformation (see paper)
    25% identity, 81% coverage of query (90.1 bits)

7zn5B / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the closed conformation, c2 symmetry. (see paper)
    25% identity, 81% coverage of query (86.7 bits)

6hndB / A0A1D8PMC5 Crystal structure of the aromatic aminotransferase aro9 from c. Albicans (see paper)
    26% identity, 74% coverage of query (86.3 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    25% identity, 73% coverage of query (85.9 bits)

6hnvB Crystal structure of aminotransferase aro9 from c. Albicans with ligands
    26% identity, 74% coverage of query (85.1 bits)

6hnvA Crystal structure of aminotransferase aro9 from c. Albicans with ligands
    26% identity, 74% coverage of query (85.1 bits)

5wmiA Arabidopsis thaliana prephenate aminotransferase mutant- t84v
    25% identity, 78% coverage of query (81.3 bits)

mfnC / Q58097 2-furaldehyde phosphate aminotransferase (EC 2.6.1.108) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MFNC_METJA / Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase; 4-HFC-P:alanine aminotransferase; EC 2.6.1.108 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase (EC 2.6.1.108) from Methanocaldococcus jannaschii (see paper)
    26% identity, 76% coverage of query (80.9 bits)

5wmhA Arabidopsis thaliana prephenate aminotransferase
    24% identity, 75% coverage of query (79.3 bits)

TAT / P17735 Tyrosine aminotransferase (EC 2.6.1.1) from Homo sapiens (see 2 papers)
ATTY_HUMAN / P17735 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Homo sapiens (Human) (see 3 papers)
    23% identity, 73% coverage of query (77.4 bits)

3dydA / P17735 Human tyrosine aminotransferase
    23% identity, 73% coverage of query (77.4 bits)

5wmlA / Q9SIE1 Arabidopsis thaliana prephenate aminotransferase mutant- k306a (see paper)
    24% identity, 75% coverage of query (77.0 bits)

ATTY_CAEEL / Q93703 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Caenorhabditis elegans (see 3 papers)
    23% identity, 72% coverage of query (76.3 bits)

Tat / P04694 tyrosine aminotransferase subunit (EC 2.6.1.1) from Rattus norvegicus (see 10 papers)
ATTY_RAT / P04694 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Rattus norvegicus (Rat) (see 2 papers)
    22% identity, 76% coverage of query (75.9 bits)

6f77A / Q02635 Crystal structure of the prephenate aminotransferase from rhizobium meliloti (see paper)
    25% identity, 76% coverage of query (73.9 bits)

AAPAT_RHIME / Q02635 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.79 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 4 papers)
Q02635 aspartate transaminase (EC 2.6.1.1); aspartate-prephenate aminotransferase (EC 2.6.1.78); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Sinorhizobium meliloti (see 2 papers)
aatA / AAA26245.1 aspartate aminotransferase from Sinorhizobium meliloti (see paper)
    25% identity, 76% coverage of query (73.9 bits)

1j32A / Q8RR70 Aspartate aminotransferase from phormidium lapideum
aspC / BAB86290.1 aspartate aminotransferase from Phormidium lapideum (see paper)
    24% identity, 72% coverage of query (68.9 bits)

2x5dD / Q9HV83 Crystal structure of a probable aminotransferase from pseudomonas aeruginosa (see paper)
    24% identity, 70% coverage of query (67.4 bits)

SMc04386 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) from Sinorhizobium meliloti 1021
AAT_RHIME / P58350 Aspartate aminotransferase; AAT; AspAT; Putative 2-aminoadipate transaminase; Transaminase A; EC 2.6.1.1; EC 2.6.1.39 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
    25% identity, 77% coverage of query (65.1 bits)

6f35A / P58350 Crystal structure of the aspartate aminotranferase from rhizobium meliloti (see paper)
    25% identity, 77% coverage of query (65.1 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    24% identity, 70% coverage of query (62.4 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    24% identity, 70% coverage of query (62.0 bits)

6l1nA Substrate bound bacf structure from bacillus subtillis
    24% identity, 70% coverage of query (62.0 bits)

1u08A / P77806 Crystal structure and reactivity of ybdl from escherichia coli identify a methionine aminotransferase function. (see paper)
    25% identity, 75% coverage of query (59.7 bits)

1iayA / P18485 Crystal structure of acc synthase complexed with cofactor plp and inhibitor avg (see paper)
    22% identity, 71% coverage of query (57.0 bits)

2o1bA / Q2FV61 Structure of aminotransferase from staphylococcus aureus
    21% identity, 75% coverage of query (49.7 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory