Searching for up to 100 curated homologs for GFF624 FitnessBrowser__Phaeo:GFF624 (337 a.a.)
Found high-coverage hits (≥70%) to 57 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
MTAP_RHORT / Q2RXH9 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) (see 2 papers)
61% identity, 86% coverage of query (372 bits)
C6KFA4 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from uncultured bacterium (see paper)
49% identity, 83% coverage of query (266 bits)
4gljA / C6KFA4 Crystal structure of methylthioadenosine phosphorylase in complex with rhodamine b (see paper)
49% identity, 83% coverage of query (266 bits)
flB / Q1EMV9 5'-fluoro-5'-deoxy-adenosine phosphorylase (EC 2.4.2.1) from Streptantibioticus cattleyicolor (see paper)
flB / CAJ20005.1 5'-fluoro-5'-deoxy-adenosine phosphorylase from Streptomyces cattleya (see paper)
51% identity, 82% coverage of query (259 bits)
MTAP_SACS2 / Q97W94 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPII; EC 2.4.2.28 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97W94 purine-nucleoside phosphorylase (EC 2.4.2.1); S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Saccharolobus solfataricus (see 3 papers)
3t94A / Q97W94 Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (mtap) ii complexed with 5'-deoxy-5'-methylthioadenosine and sulfate (see paper)
47% identity, 78% coverage of query (224 bits)
MTAP_PYRFU / Q8U4Q8 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; PfMTAP; EC 2.4.2.28 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
Q8U4Q8 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Pyrococcus furiosus (see paper)
45% identity, 74% coverage of query (223 bits)
MTAP / Q13126 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Homo sapiens (see 5 papers)
MTAP_HUMAN / Q13126 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Homo sapiens (Human) (see 6 papers)
Q13126 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Homo sapiens (see 8 papers)
44% identity, 74% coverage of query (219 bits)
5tc5A / Q13126 Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-dadme-immucillin-a and chloride
45% identity, 73% coverage of query (219 bits)
6dz0A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3- ol
44% identity, 74% coverage of query (219 bits)
6dz3A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1h-1,2,3-triazol-4-yl) propyl)thio)methyl)pyrrolidin-3-ol
45% identity, 73% coverage of query (219 bits)
6dyzA Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3- ol
45% identity, 73% coverage of query (219 bits)
5tc8A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-dadme-immucillin-a
45% identity, 73% coverage of query (219 bits)
5tc6A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-a
45% identity, 73% coverage of query (219 bits)
3ozcA Crystal structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pcl-phenylthiodadmeimma
45% identity, 73% coverage of query (219 bits)
5eubA Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-mta and sulfate
45% identity, 73% coverage of query (219 bits)
1wtaA / Q9YAQ8 Crystal structure of 5'-deoxy-5'-methylthioadenosine from aeropyrum pernix (r32 form)
47% identity, 76% coverage of query (218 bits)
1sd2A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-methylthiotubercidin
46% identity, 73% coverage of query (218 bits)
MTAP_SCHPO / Q09816 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
44% identity, 74% coverage of query (217 bits)
pnp / Q5JEQ6 adenosine phosphorylase (EC 2.4.2.1) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
MTAP_THEKO / Q5JEQ6 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; Nucleoside phosphorylase; EC 2.4.2.28 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
45% identity, 74% coverage of query (216 bits)
1k27A Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with a transition state analogue
45% identity, 73% coverage of query (215 bits)
1sd1A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with formycin a
45% identity, 73% coverage of query (214 bits)
1cg6A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-deoxy-5'-methylthioadenosine and sulfate at 1.7 a resolution
45% identity, 73% coverage of query (214 bits)
1cb0A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 a resolution
45% identity, 73% coverage of query (214 bits)
6dz2A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1h-1,2,3-triazol-4-yl) propyl)thio)methyl)pyrrolidin-3-ol
44% identity, 73% coverage of query (209 bits)
5f7jB / I0B503 Crystal structure of mutant n87t of adenosine/methylthioadenosine phosphorylase from schistosoma mansoni in complex with adenine (see paper)
39% identity, 72% coverage of query (196 bits)
I0B503 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Schistosoma mansoni (see paper)
39% identity, 72% coverage of query (196 bits)
TK1482 / Q5JJB8 guanosine phosphorylase (EC 2.4.2.15) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
PNPH_THEKO / Q5JJB8 Probable 6-oxopurine nucleoside phosphorylase; Purine nucleoside phosphorylase; PNP; EC 2.4.2.1 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
42% identity, 77% coverage of query (192 bits)
PNPH_PYRFU / Q8U2I1 6-oxopurine nucleoside phosphorylase; Purine nucleoside phosphorylase; PNP; PfPNP; EC 2.4.2.1 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 2 papers)
Q8U2I1 purine-nucleoside phosphorylase (EC 2.4.2.1) from Pyrococcus furiosus (see 2 papers)
41% identity, 77% coverage of query (190 bits)
MTAP_YEAST / Q07938 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; Multicopy enhancer of UAS2; EC 2.4.2.28 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
37% identity, 82% coverage of query (185 bits)
MTAP_MYCS2 / A0QR54 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
43% identity, 70% coverage of query (181 bits)
salT / B0L7E7 chloro-purine nucleoside phosphorylase (EC 2.4.2.1) from Salinispora tropica (see paper)
B0L7E7 purine-nucleoside phosphorylase (EC 2.4.2.1) from Salinispora tropica (see paper)
41% identity, 76% coverage of query (177 bits)
MTAP_MYCTU / O06401 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O06401 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Mycobacterium tuberculosis (see paper)
43% identity, 70% coverage of query (172 bits)
Build an alignment for GFF624 and 32 homologs with ≥ 30% identity
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4lnaA / D2QIK7 Crystal structure of purine nucleoside phosphorylase i from spirosoma linguale dsm 74, nysgrc target 029362
27% identity, 70% coverage of query (72.0 bits)
7zslA Human purine nucleoside phosphorylase in complex with js-196
23% identity, 74% coverage of query (55.5 bits)
4earA Crystal structure of purine nucleoside phosphorylase (w16y, w94y, w178y, h257w) mutant from human complexed with dadme-immg and phosphate
22% identity, 74% coverage of query (53.9 bits)
3ggsA Human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2'-deoxyadenosine
22% identity, 74% coverage of query (50.8 bits)
3gb9A Human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoroadenine
22% identity, 74% coverage of query (50.8 bits)
3d1vA / P00491 Crystal structure of human pnp complexed with 2-mercapto(3h) quinazolinone (see paper)
22% identity, 74% coverage of query (50.1 bits)
3phbE Crystal structure of human purine nucleoside phosphorylase in complex with dadme-immg
22% identity, 74% coverage of query (50.1 bits)
3k8oE Crystal structure of human purine nucleoside phosphorylase in complex with datme-immh
22% identity, 74% coverage of query (50.1 bits)
3k8qA Crystal structure of human purine nucleoside phosphorylase in complex with serme-immucillin h
22% identity, 74% coverage of query (50.1 bits)
3inyA Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine
22% identity, 74% coverage of query (50.1 bits)
1yryE Crystal structure of human pnp complexed with mesg
22% identity, 74% coverage of query (50.1 bits)
1v45E Crystal structure of human pnp complexed with 3-deoxyguanosine
22% identity, 74% coverage of query (50.1 bits)
1v41E Crystal structure of human pnp complexed with 8-azaguanine
22% identity, 74% coverage of query (50.1 bits)
1v3qE Structure of human pnp complexed with ddi
22% identity, 74% coverage of query (50.1 bits)
1v2hE Crystal structure of human pnp complexed with guanine
22% identity, 74% coverage of query (50.1 bits)
1rfgE Crystal structure of human purine nucleoside phosphorylase complexed with guanosine
22% identity, 74% coverage of query (50.1 bits)
1rctE Crystal structure of human purine nucleoside phosphorylase complexed with inosine
22% identity, 74% coverage of query (50.1 bits)
1pwyE Crystal structure of human pnp complexed with acyclovir
22% identity, 74% coverage of query (50.1 bits)
1pf7E Crystal structure of human pnp complexed with immucillin h
22% identity, 74% coverage of query (50.1 bits)
1rszA Structure of human purine nucleoside phosphorylase in complex with dadme-immucillin-h and sulfate
22% identity, 74% coverage of query (50.1 bits)
PNP / P00491 purine nucleoside phosphorylase subunit (EC 2.4.2.1; EC 2.4.2.15) from Homo sapiens (see 9 papers)
PNPH_HUMAN / P00491 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Homo sapiens (Human) (see 6 papers)
P00491 purine-nucleoside phosphorylase (EC 2.4.2.1) from Homo sapiens (see 29 papers)
22% identity, 74% coverage of query (49.3 bits)
7zsoA Human purine nucleoside phosphorylase in complex with js-554
22% identity, 74% coverage of query (49.3 bits)
7zsnA Human purine nucleoside phosphorylase in complex with js-379
22% identity, 74% coverage of query (49.3 bits)
7zsmA Human purine nucleoside phosphorylase in complex with js-375
22% identity, 74% coverage of query (49.3 bits)
7zspA Human purine nucleoside phosphorylase in complex with js-555
22% identity, 74% coverage of query (48.9 bits)
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Lawrence Berkeley National Laboratory