Searching for up to 100 curated homologs for GFF644 PGA1_c06580 ketol-acid reductoisomerase IlvC (340 a.a.)
Found high-coverage hits (≥70%) to 75 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ilvC / Q0KCU2 acetohydroxyacid isomeroreductase (EC 1.1.1.86) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
67% identity, 100% coverage of query (474 bits)
ILVC_AZOVD / C1DFH7 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Azotobacter vinelandii (strain DJ / ATCC BAA-1303) (see paper)
C1DFH7 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Azotobacter vinelandii (see paper)
61% identity, 100% coverage of query (441 bits)
ILVC_PSEAE / Q9HVA2 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
60% identity, 100% coverage of query (432 bits)
7latA / Q9PHN5 Campylobacter jejuni keto-acid reductoisomerase in complex with mg2+
63% identity, 97% coverage of query (431 bits)
7rduA Crystal structure of campylobacter jejuni keto said reductoisomerase in complex with magnesium and oxidixized and reduced NADPH
63% identity, 97% coverage of query (431 bits)
4xiyA / C1DFH7 Crystal structure of ketol-acid reductoisomerase from azotobacter (see paper)
61% identity, 97% coverage of query (427 bits)
D3PT81 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Meiothermus ruber (see paper)
61% identity, 97% coverage of query (421 bits)
8cy8A Apo form cryo-em structure of campylobacter jejune ketol-acid reductoisommerase crosslinked by glutaraldehyde
59% identity, 97% coverage of query (397 bits)
ILVC_THEPS / K4LVZ1 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 26808 / PB) (see paper)
56% identity, 97% coverage of query (383 bits)
ILVC_MYCTU / P9WKJ7 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
A5U713 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Mycobacterium tuberculosis (see paper)
P9WKJ7 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Mycobacterium tuberculosis (see 6 papers)
54% identity, 97% coverage of query (373 bits)
ILVC_ALIAD / C8WR67 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-IA) (Bacillus acidocaldarius) (see paper)
C8WR67 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Alicyclobacillus acidocaldarius subsp. acidocaldarius (see 2 papers)
56% identity, 99% coverage of query (373 bits)
ilvC / AAB38428.1 acetohydroxy acid isomeroreductase from Mycobacterium avium (see paper)
54% identity, 96% coverage of query (373 bits)
4tskA / C8WR67 Ketol-acid reductoisomerase from alicyclobacillus acidocaldarius (see paper)
56% identity, 99% coverage of query (372 bits)
4ypoA / P9WKJ7 Crystal structure of mycobacterium tuberculosis ketol-acid reductoisomerase in complex with mg2+ (see paper)
55% identity, 96% coverage of query (372 bits)
ILVC_SLAES / D0WGK0 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Slackia exigua (strain ATCC 700122 / DSM 15923 / CIP 105133 / JCM 11022 / KCTC 5966 / S-7) (see paper)
D0WGK0 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Slackia exigua (see paper)
55% identity, 96% coverage of query (366 bits)
4kqwA The structure of the slackia exigua kari in complex with NADP
55% identity, 96% coverage of query (366 bits)
8ep7C / Q81S27 Crystal structure of the ketol-acid reductoisomerase from bacillus anthracis in complex with NADP
55% identity, 97% coverage of query (365 bits)
A0A0K2AZ61 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces ambofaciens (see paper)
56% identity, 96% coverage of query (364 bits)
Q57179 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Corynebacterium glutamicum (see paper)
55% identity, 97% coverage of query (364 bits)
6jx2B / Q57179 Crystal structure of ketol-acid reductoisomerase from corynebacterium glutamicum (see paper)
55% identity, 97% coverage of query (363 bits)
4kqxB / D0WGK0 Mutant slackia exigua kari ddv in complex with NAD and an inhibitor (see paper)
54% identity, 97% coverage of query (361 bits)
ilvC / AAL99358.2 ketol-acid reductoisomerase from Geobacillus stearothermophilus (see paper)
55% identity, 97% coverage of query (360 bits)
Q59818 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces avermitilis (see paper)
55% identity, 96% coverage of query (358 bits)
6jx2A Crystal structure of ketol-acid reductoisomerase from corynebacterium glutamicum
56% identity, 96% coverage of query (358 bits)
D6ERQ9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans (see paper)
Q9Z565 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor (see paper)
57% identity, 96% coverage of query (357 bits)
Q9FBT8 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor (see paper)
56% identity, 96% coverage of query (356 bits)
D6EC76 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans (see paper)
56% identity, 96% coverage of query (353 bits)
ILVC_SYNWW / Q0AV19 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
53% identity, 98% coverage of query (353 bits)
ILVC_HYDS0 / B4U6I9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Hydrogenobaculum sp. (strain Y04AAS1) (see paper)
55% identity, 98% coverage of query (351 bits)
A6UW80 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Methanococcus aeolicus (see paper)
52% identity, 96% coverage of query (347 bits)
6bulB / Q2YUF3 Crystal structure of staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2
54% identity, 96% coverage of query (345 bits)
6vo2A Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex with mg, NADPH and inhibitor.
54% identity, 96% coverage of query (345 bits)
6c5nA Crystal structure of staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1
54% identity, 96% coverage of query (345 bits)
6c55A Crystal structure of staphylococcus aureus ketol-acid reductosimerrase with hydroxyoxamate inhibitor 3
54% identity, 96% coverage of query (345 bits)
6aqjA Crystal structures of staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity.
54% identity, 96% coverage of query (345 bits)
5w3kA Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, mg2+ and cpd
54% identity, 96% coverage of query (345 bits)
Q2FWK4 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Staphylococcus aureus (see 3 papers)
54% identity, 97% coverage of query (343 bits)
7q03A Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus in the close state with NADP and mg2+ (see paper)
52% identity, 96% coverage of query (342 bits)
ILVC_LACLA / Q02138 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
Q02138 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Lactococcus lactis subsp. lactis (see paper)
53% identity, 97% coverage of query (334 bits)
ILVC_ARCFU / O28294 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
O28294 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382) from Archaeoglobus fulgidus (see paper)
53% identity, 97% coverage of query (333 bits)
6l2iA / Q04M32 Ilvc, a ketol-acid reductoisomerase, from streptococcus pneumoniae_wt
53% identity, 96% coverage of query (330 bits)
6l2iB Ilvc, a ketol-acid reductoisomerase, from streptococcus pneumoniae_wt
53% identity, 96% coverage of query (327 bits)
7ke2A Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex with mg2+ and nsc116565
53% identity, 95% coverage of query (322 bits)
ilvC / O27491 acetohydroxy-acid isomeroreductase subunit (EC 1.1.1.383) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 3 papers)
51% identity, 96% coverage of query (316 bits)
5e4rA / E0SRA9 Crystal structure of domain-duplicated synthetic class ii ketol-acid reductoisomerase 2ia_kari-dd (see paper)
48% identity, 96% coverage of query (301 bits)
ILVC_IGNAA / E0SRA9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1) (see 3 papers)
E0SRA9 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Ignisphaera aggregans (see paper)
48% identity, 96% coverage of query (301 bits)
4xdzA Holo structure of ketol-acid reductoisomerase from ignisphaera aggregans
48% identity, 96% coverage of query (300 bits)
ILVC_UNCAG / Q64BR7 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Uncultured archaeon GZfos26G2 (see paper)
Q64BR7 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from uncultured archaeon GZfos26G2 (see paper)
46% identity, 96% coverage of query (292 bits)
4xdyA / Q64BR7 Structure of nadh-preferring ketol-acid reductoisomerase from an uncultured archean (see paper)
46% identity, 96% coverage of query (292 bits)
5yeqB / Q4J8K9 The structure of sac-kari protein (see paper)
49% identity, 96% coverage of query (285 bits)
Q4J8K9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Sulfolobus acidocaldarius (see paper)
49% identity, 96% coverage of query (285 bits)
ILVC_METS5 / A4YI15 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
45% identity, 96% coverage of query (271 bits)
P78827 Probable ketol-acid reductoisomerase, mitochondrial; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.86 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
36% identity, 84% coverage of query (154 bits)
A0KS29 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Shewanella sp. (see paper)
34% identity, 83% coverage of query (150 bits)
7pcoA Burg e232q mutant (holo) in complex with 2r,3r-2,3-dihydroxy-6-methyl- heptanoate (12): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (147 bits)
7pctA Burg e232q mutant (holo) in complex with enol-oxalacetate (15): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (147 bits)
7pciA / Q2T3G7 Burg (holo) in complex with hydroxypyruvate-enol (8): biosynthesis of cyclopropanol rings in bacterial toxins (see paper)
30% identity, 94% coverage of query (146 bits)
7pceA Burg (apo): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (146 bits)
7pcmA Burg (holo) in complex with (z)-2,3-dihydroxy-6-methyl-hept-2-enoate (13): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (146 bits)
7pclA Burg (holo) in complex with 2-hydroxy-2-(hydroxy(isopropyl)amino) acetate (11): biosynthesis of cyclopropanolrings in bacterial toxins
30% identity, 94% coverage of query (146 bits)
7pcgA Burg (holo) in complex with cyclopropane-1,1-dicarboxylate (7): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (146 bits)
7pcnA Burg (holo) in complex with gonyenediol (14), trigonic acid (6) and dms: biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 94% coverage of query (146 bits)
3ulkA / P05793 E. Coli ketol-acid reductoisomerase in complex with NADPH and mg2+ (see paper)
34% identity, 84% coverage of query (134 bits)
IlvC / b3774 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ilvC / P05793 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli (strain K12) (see 40 papers)
ILVC_ECOLI / P05793 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Escherichia coli (strain K12) (see 9 papers)
P05793 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Escherichia coli (see 3 papers)
ilvC ketol-acid reductoisomerase; EC 1.1.1.86 from Escherichia coli K12 (see 2 papers)
34% identity, 84% coverage of query (134 bits)
ILVC_SALTY / P05989 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
34% identity, 84% coverage of query (132 bits)
A6TGG1 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Klebsiella pneumoniae subsp. pneumoniae (see paper)
34% identity, 84% coverage of query (131 bits)
6jczC / Q97YJ9 Cryo-em structure of sulfolobus solfataricus ketol-acid reductoisomerase (sso-kari) in complex with mg2+, NADPH, and cpd at ph7.5 (see paper)
32% identity, 87% coverage of query (130 bits)
6jd1A Cryo-em structure of sulfolobus solfataricus ketol-acid reductoisomerase (sso-kari) in complex with mg2+, nadh, and cpd at ph7.5
32% identity, 87% coverage of query (130 bits)
ILVC_DESOH / A8ZTR0 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.382 from Desulfosudis oleivorans (strain DSM 6200 / JCM 39069 / Hxd3) (Desulfococcus oleovorans) (see paper)
34% identity, 75% coverage of query (129 bits)
7tocA / A0A2H0ZMH9 Crystal structure of the mitochondrial ketol-acid reductoisomerase ilvc from candida auris
34% identity, 84% coverage of query (125 bits)
ILV5 mitochondrial ketol-acid reductoisomerase from Candida albicans (see paper)
30% identity, 99% coverage of query (125 bits)
ILV5_YEAST / P06168 Ketol-acid reductoisomerase, mitochondrial; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Isoleucine-plus-valine requiring protein 5; EC 1.1.1.86 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 84% coverage of query (118 bits)
Build an alignment for GFF644 and 72 homologs with ≥ 30% identity
Or download the sequences
1qmgA / Q01292 Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and adp-ribose. (see paper)
28% identity, 91% coverage of query (103 bits)
ILV5_SPIOL / Q01292 Ketol-acid reductoisomerase, chloroplastic; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.86 from Spinacia oleracea (Spinach) (see 3 papers)
28% identity, 91% coverage of query (103 bits)
1yveI Acetohydroxy acid isomeroreductase complexed with NADPH, magnesium and inhibitor ipoha (n-hydroxy-n-isopropyloxamate)
28% identity, 91% coverage of query (103 bits)
Or start over
Lawrence Berkeley National Laboratory