Searching for up to 100 curated homologs for GFF789 FitnessBrowser__Marino:GFF789 (511 a.a.)
Found high-coverage hits (≥70%) to 98 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
HerC / b2890 lysine—tRNA ligase, constitutive (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 53 papers)
lysS / P0A8N3 lysine—tRNA ligase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 53 papers)
lysS lysine--tRNA ligase; EC 6.1.1.6 from Escherichia coli K12 (see paper)
62% identity, 95% coverage of query (624 bits)
LysU / b4129 lysine—tRNA ligase/Ap4A synthetase/Ap3A synthetase (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 70 papers)
lysU / P0A8N5 lysyl-tRNA synthetase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 73 papers)
P0A8N5 lysine-tRNA ligase (EC 6.1.1.6) from Escherichia coli (see paper)
lysU / RF|NP_418553 lysyl-tRNA synthetase, heat inducible; EC 6.1.1.6 from Escherichia coli K12 (see 10 papers)
61% identity, 95% coverage of query (622 bits)
P0A8N5 Lysine--tRNA ligase, heat inducible; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Escherichia coli (strain K12)
61% identity, 95% coverage of query (622 bits)
1bbuA / P0A8N3 Lysyl-tRNA synthetase (lyss) complexed with lysine (see paper)
61% identity, 95% coverage of query (612 bits)
1e1tA / P0A8N5 Lysyl-tRNA synthetase (lysu) hexagonal form complexed with the lysyl_adenylate intermediate (see paper)
61% identity, 95% coverage of query (608 bits)
1e24A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and atp and mn2+
61% identity, 95% coverage of query (608 bits)
1e22A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and the non-hydrolysable atp analogue amp-pcp
61% identity, 95% coverage of query (608 bits)
5yzxA Crystal structure of e.Coli lysu t146d mutant
61% identity, 95% coverage of query (606 bits)
1e1oA Lysyl-tRNA synthetase (lysu) hexagonal form, complexed with lysine
61% identity, 95% coverage of query (602 bits)
4ex5A / Q2SXD6 Crystal structure of lysyl-tRNA synthetase lysrs from burkholderia thailandensis bound to lysine (see paper)
56% identity, 95% coverage of query (546 bits)
6wbdB / B2FQ84 Crystal structure of lysyl-tRNA synthetase from stenotrophomonas maltophilia with bound l-lysine
55% identity, 96% coverage of query (542 bits)
SYK_STAAU / Q53638 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Staphylococcus aureus (see paper)
51% identity, 95% coverage of query (476 bits)
Q9RHV9 lysine-tRNA ligase (EC 6.1.1.6) from Geobacillus stearothermophilus (see 3 papers)
50% identity, 96% coverage of query (473 bits)
3a74A / Q9RHV9 Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with diadenosine tetraphosphate (ap4a)
49% identity, 95% coverage of query (462 bits)
3e9iA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysine hydroxamate-amp
49% identity, 95% coverage of query (462 bits)
3e9hA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysylsulfamoyl adenosine
49% identity, 95% coverage of query (462 bits)
Q1D380 lysine-tRNA ligase (EC 6.1.1.6) from Myxococcus xanthus (see 2 papers)
48% identity, 96% coverage of query (454 bits)
Q04LI2 lysine-tRNA ligase (EC 6.1.1.6) from Streptococcus pneumoniae (see paper)
46% identity, 94% coverage of query (399 bits)
SYKM_ARATH / Q9LJE2 Lysine--tRNA ligase, chloroplastic/mitochondrial; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 2; AtKRS-2; Protein OVULE ABORTION 5; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
41% identity, 94% coverage of query (382 bits)
P15180 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
42% identity, 96% coverage of query (373 bits)
4up7A / C4M7X2 Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate (see paper)
41% identity, 97% coverage of query (372 bits)
SYK_MOUSE / Q99MN1 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Mus musculus (Mouse) (see paper)
Q99MN1 lysine-tRNA ligase (EC 6.1.1.6) from Mus musculus (see paper)
40% identity, 99% coverage of query (369 bits)
Q580G3 lysine-tRNA ligase (EC 6.1.1.6) from Trypanosoma brucei (see paper)
40% identity, 94% coverage of query (369 bits)
SYK_CRIGR / P37879 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
40% identity, 96% coverage of query (368 bits)
SYK_HUMAN / Q15046 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Homo sapiens (Human) (see 25 papers)
Q15046 lysine-tRNA ligase (EC 6.1.1.6) from Homo sapiens (see 12 papers)
40% identity, 96% coverage of query (367 bits)
SYK_RAT / Q5XIM7 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Rattus norvegicus (Rat) (see 5 papers)
40% identity, 96% coverage of query (365 bits)
4ycuA Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase
40% identity, 95% coverage of query (364 bits)
6chdA / Q15046 Crystal structure of human lysyl-tRNA synthetase complexed with l- lysylsulfamoyl adenosine
40% identity, 95% coverage of query (363 bits)
7f6wA / P15180 Crystal structure of saccharomyces cerevisiae lysyl-tRNA synthetase (see paper)
41% identity, 94% coverage of query (362 bits)
Q8IDJ8 lysine-tRNA ligase (EC 6.1.1.6) from Plasmodium falciparum (see 2 papers)
40% identity, 95% coverage of query (358 bits)
SYK_CAEEL / Q22099 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Caenorhabditis elegans (see paper)
41% identity, 96% coverage of query (358 bits)
6agtB / Q8IDJ8 Crystal structure of pfkrs complexed with chromone inhibitor (see paper)
40% identity, 95% coverage of query (357 bits)
6kctA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5
40% identity, 95% coverage of query (357 bits)
6kabA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2
40% identity, 95% coverage of query (357 bits)
6kbfA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
40% identity, 95% coverage of query (357 bits)
3bjuA Crystal structure of tetrameric form of human lysyl-tRNA synthetase
40% identity, 95% coverage of query (355 bits)
4dpgA Crystal structure of human lysrs: p38/aimp2 complex i
40% identity, 95% coverage of query (353 bits)
4up9A Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with atp
40% identity, 97% coverage of query (351 bits)
CLA4_CLACD / A0A120HYZ1 Lysine--tRNA ligase cla4; Cladosporin biosynthesis cluster protein 4; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Cladosporium cladosporioides (see paper)
38% identity, 100% coverage of query (350 bits)
6ildB Crystal structure of human lysrs: p38/aimp2 complex ii
40% identity, 95% coverage of query (350 bits)
4upaA Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with amppnp
40% identity, 97% coverage of query (350 bits)
4ycwA Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant
40% identity, 95% coverage of query (347 bits)
6kcnA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
40% identity, 95% coverage of query (344 bits)
J5K1T7 lysine-tRNA ligase (EC 6.1.1.6) from Beauveria bassiana (see paper)
37% identity, 95% coverage of query (343 bits)
5hgqB Loa loa lysyl-tRNA synthetase in complex with cladosporin. (see paper)
41% identity, 96% coverage of query (341 bits)
6m0tA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and cladosporin derivative (cl-2)
40% identity, 95% coverage of query (341 bits)
6l4qA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-b
39% identity, 95% coverage of query (340 bits)
6aqgC / A0PV47 Crystal structure of lysyl-tRNA synthetase from mycobacterium ulcerans complexed with l-lysine and cladosporin
42% identity, 94% coverage of query (338 bits)
A0R577 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
41% identity, 97% coverage of query (338 bits)
6ka6A Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
39% identity, 95% coverage of query (336 bits)
SYKC_ARATH / Q9ZPI1 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 1; AtKRS-1; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 97% coverage of query (333 bits)
A0QHC4 lysyltransferase (EC 2.3.2.3) from Mycobacterium avium (see paper)
42% identity, 85% coverage of query (333 bits)
6bniA / Q5CR27 Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and adenosine
39% identity, 94% coverage of query (333 bits)
6hcwA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and a difluoro cyclohexyl chromone ligand
39% identity, 94% coverage of query (333 bits)
6c86A Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysylsulfamoyl adenosine
39% identity, 94% coverage of query (333 bits)
5eloA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and cladosporin
39% identity, 94% coverage of query (333 bits)
4pg3A Crystal structure of krs complexed with inhibitor
39% identity, 95% coverage of query (332 bits)
7bt5A Crystal structure of plasmodium lysrs complexing with an antitumor compound
39% identity, 95% coverage of query (330 bits)
6hcuA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
39% identity, 95% coverage of query (328 bits)
6aqhB / G7CF12 Crystal structure of lysyl-tRNA synthetase from mycobacterium thermoresistibile complexed with l-lysine and cladosporin
41% identity, 94% coverage of query (327 bits)
A0QYV1 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
40% identity, 94% coverage of query (323 bits)
5zh4A Crystal structure of pfkrs with inhibitor clado-7
38% identity, 95% coverage of query (323 bits)
6l3yA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-c
39% identity, 95% coverage of query (322 bits)
5zh2A / W7JP72 Crystal structure of pfkrs with inhibitor clado-5 (see paper)
38% identity, 95% coverage of query (321 bits)
LYSX_MYCTU / P9WFU7 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; EC 6.1.1.6; EC 2.3.2.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
A5U2Z7 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see paper)
P9WFU7 lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see 2 papers)
39% identity, 94% coverage of query (321 bits)
5zh5A Crystal structure of pfkrs with inhibitor clado-2
39% identity, 95% coverage of query (321 bits)
5zh4B Crystal structure of pfkrs with inhibitor clado-7
38% identity, 95% coverage of query (319 bits)
7zogA Crystal structure of cryptosporidium parvum -plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
38% identity, 94% coverage of query (318 bits)
6hcvA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with a chromone ligand
38% identity, 95% coverage of query (318 bits)
5zh3B Crystal structure of pfkrs with inhibitor clado-6
38% identity, 95% coverage of query (316 bits)
5zh3A Crystal structure of pfkrs with inhibitor clado-6
38% identity, 95% coverage of query (315 bits)
6nrzA / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
6nrzB / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
37% identity, 94% coverage of query (307 bits)
6o3fA Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis with complexed with l-lysine and a difluoro cyclohexyl chromone ligand
37% identity, 94% coverage of query (307 bits)
6ns0A Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and cladosporin
37% identity, 94% coverage of query (307 bits)
7qh8A / P9WFU9 Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine (see paper)
40% identity, 93% coverage of query (306 bits)
7qi8A Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and inhibitor
39% identity, 93% coverage of query (304 bits)
7qhnA Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and an inhibitor
39% identity, 91% coverage of query (296 bits)
SYKM_SCHPO / O74858 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
36% identity, 84% coverage of query (263 bits)
SYKM_YEAST / P32048 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P32048 lysine-tRNA ligase (EC 6.1.1.6) from Saccharomyces cerevisiae (see paper)
34% identity, 71% coverage of query (182 bits)
SYDND_HALSA / O07683 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
O07683 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Halobacterium salinarum (see paper)
30% identity, 82% coverage of query (122 bits)
Build an alignment for GFF789 and 80 homologs with ≥ 30% identity
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SYDND_METMA / Q8Q0R2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) (see paper)
27% identity, 89% coverage of query (120 bits)
SYDND_METTH / O26328 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
O26328 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Methanothermobacter thermautotrophicus (see paper)
26% identity, 82% coverage of query (110 bits)
1b8aA / Q52428 Aspartyl-tRNA synthetase (see paper)
26% identity, 88% coverage of query (100 bits)
SYD_THEKO / Q52428 Aspartate--tRNA(Asp) ligase; Aspartyl-tRNA synthetase; AspRS; Discriminating aspartyl-tRNA synthetase; D-AspRS; EC 6.1.1.12 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 4 papers)
Q52428 aspartate-tRNA ligase (EC 6.1.1.12) from Thermococcus kodakarensis (see 4 papers)
26% identity, 88% coverage of query (99.8 bits)
SYDND_THET8 / Q5SIC2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 4 papers)
Q5SIC2 aspartate-tRNA ligase (EC 6.1.1.12) from Thermus thermophilus (see paper)
27% identity, 86% coverage of query (99.8 bits)
3nemB Aspartyl-tRNA synthetase complexed with aspartyl adenylate
26% identity, 88% coverage of query (99.8 bits)
3nemA Aspartyl-tRNA synthetase complexed with aspartyl adenylate
26% identity, 88% coverage of query (99.8 bits)
3nelA Aspartyl-tRNA synthetase complexed with aspartic acid
26% identity, 88% coverage of query (99.8 bits)
4o2dB / A0QWN3 Crystal structure of aspartyl-tRNA synthetase from mycobacterium smegmatis with bound aspartic acid (see paper)
25% identity, 73% coverage of query (93.6 bits)
3kfuC / Q5SIC2 Crystal structure of the transamidosome (see paper)
26% identity, 86% coverage of query (84.3 bits)
erdS / Q4WKG3 aspartate--tRNA ligase/ergosteryl-3β-O-L-aspartate synthase (EC 6.1.1.23; EC 2.3.2.37) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see paper)
25% identity, 77% coverage of query (83.6 bits)
Q585M3 aspartate-tRNA ligase (EC 6.1.1.12) from Trypanosoma brucei (see paper)
23% identity, 84% coverage of query (80.5 bits)
C4LZN0 aspartate-tRNA ligase (EC 6.1.1.12); aspartate-tRNAAsn ligase (EC 6.1.1.23) from Entamoeba histolytica (see paper)
26% identity, 71% coverage of query (79.7 bits)
8tc9A Human asparaginyl-tRNA synthetase bound to osm-s-106
23% identity, 82% coverage of query (75.9 bits)
8h53A Human asparaginyl-tRNA synthetase in complex with asparagine-amp
23% identity, 82% coverage of query (73.6 bits)
1x55A Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
23% identity, 88% coverage of query (65.1 bits)
1x54A / O57980 Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate (see paper)
23% identity, 88% coverage of query (65.1 bits)
3m4pA / C4LWW8 Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs) in complex with asparaginyl-adenylate
20% identity, 85% coverage of query (64.3 bits)
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Lawrence Berkeley National Laboratory