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Searching for up to 100 curated homologs for GFF854 FitnessBrowser__WCS417:GFF854 (154 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PtsN / b3204 phosphotransferase system enzyme IIA(Ntr) from Escherichia coli K-12 substr. MG1655 (see 22 papers)
ptsN / AAB60165.1 Enzyme IIANtr from Escherichia coli (see 3 papers)
    48% identity, 85% coverage of query (117 bits)

TC 4.A.2.1.14 / D2RXA7 Putative PTS IIA-like nitrogen-regulatory protein PtsN, component of Fructose Enzyme II complex (IIAFru - IIBFru - IICFru) (based on homology) from Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (see paper)
    36% identity, 95% coverage of query (87.0 bits)

TC 4.A.2.1.26 / Q5V5X4 Sugar hosphotransferase system IIA component, component of Fructose-specific Enzyme I-HPr-Enzyme IIABC complex, all encoded within a single operon with genes in the order: ptsC (IIC), ptsA (IIA), ptsH (HPr), ptsI (Enzyme I) and ptsB (IIB) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
    34% identity, 88% coverage of query (78.2 bits)

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Build an alignment for GFF854 and 3 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 4.A.2.1.4 / P71012 The fructose porter, FruA (fructose-1-P forming IIABC) (Delobbe et al. 1975) FruA is 39% identical to 4.A.2.1.1). fructose can be metabolized to Fru-1-P via this system as well as Fru-6-P by another PTS system from Bacillus subtilis (see paper)
    27% identity, 95% coverage of query (76.6 bits)

TC 4.A.2.1.7 / Q1LZ59 The fructose inducible fructose/xylitol porter, FruI from Streptococcus mutans UA159 (see paper)
    27% identity, 87% coverage of query (70.9 bits)

tagM / A0A1Y0YTF1 tagatose-specific PTS enzyme IIA component from Bacillus licheniformis (see 2 papers)
TC 4.A.2.1.23 / T5HNP5 PTS fructose transporter subunit IIA, component of The tagatose-1-P-forming tagatose phosphorylating Enzyme IIA/IIBC, TagM/L (Van der Heiden et al. 2015). The product is phosphorylated by tagatose-1-P kinase (TagK), and then cleaved by tagatose-1,6-bisphosphate aldolase (GatY) from Bacillus licheniformis CG-B52
    33% identity, 78% coverage of query (68.9 bits)

PTN3B_BACSU / O31645 PTS system mannose-specific EIIBCA component; EIIBCA-Man; EII-Man; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see 2 papers)
O31645 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Bacillus subtilis (see paper)
TC 4.A.2.1.6 / O31645 The mannose porter (ManP) (37% identical to 4.A.2.1.1). It is encoded in an operon with 3 genes: from Bacillus subtilis (see 5 papers)
    25% identity, 94% coverage of query (63.2 bits)

FrvA / b3900 putative PTS enzyme IIA component FrvA from Escherichia coli K-12 substr. MG1655 (see paper)
TC 4.A.2.1.25 / P32155 Fructose-like phosphotransferase enzyme IIA component, component of Fructose-like PTS Enzyme II complex, FrvA (IIA of 148 aas) - FrvB (IIBC of 483 aas and 9 predicted TMSs) from Escherichia coli (strain K12)
    25% identity, 84% coverage of query (58.9 bits)

MngA 2-O-α-mannosyl-D-glycerate specific PTS enzyme II (EC 2.7.1.195) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
MngA / P54745 2-O-α-mannosyl-D-glycerate specific PTS enzyme II (EC 2.7.1.195) from Escherichia coli (strain K12) (see 5 papers)
MNGA_ECOLI / P54745 PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component; 2-O-alpha-mannosyl-D-glycerate-specific phosphotransferase enzyme MngA; Protein-Npi-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase; EC 2.7.1.195 from Escherichia coli (strain K12) (see 2 papers)
P54745 protein-Npi-phosphohistidine-2-O-alpha-mannosyl-D-glycerate phosphotransferase (EC 2.7.1.195) from Escherichia coli (see paper)
TC 4.A.2.1.3 / P54745 The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) from Escherichia coli (see 5 papers)
    28% identity, 99% coverage of query (58.5 bits)

TC 4.A.2.1.9 / Q1R4S9 Putative phosphotransferase system (PTS), fructose-specific, component of The FrzABC PTS putative transporter (promotes bacterial fitness under stress conditions and promotes fimbrial (fim) gene expression indirectly (Rouquet et al., 2009). Might transport D-tagatose, D-psicose and/or D-sorbose, or a disaccharide of these (Rouquet et al. 2009); involved in environmental sensing, host adaptation and virulence from Escherichia coli (strain UTI89 / UPEC) (see paper)
    29% identity, 83% coverage of query (57.0 bits)

FruB / b2169 fructose-specific PTS multiphosphoryl transfer protein FruB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
FruB / P69811 fructose-specific PTS multiphosphoryl transfer protein FruB from Escherichia coli (strain K12) (see 2 papers)
PTFAH_ECOLI / P69811 Multiphosphoryl transfer protein; MTP; Diphosphoryl transfer protein; DTP; Phosphotransferase FPr protein; Pseudo-HPr from Escherichia coli (strain K12) (see paper)
TC 4.A.2.1.1 / P69811 PTFA aka FRUB aka FRUF aka FPR aka B2169, component of Fructose porter (FruAB) (fructose-1-P forming) from Escherichia coli (see 5 papers)
    31% identity, 89% coverage of query (50.4 bits)

PTFAH_SALTY / P17127 Multiphosphoryl transfer protein; MTP; Diphosphoryl transfer protein; DTP; Phosphotransferase FPr protein; Pseudo-HPr from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    30% identity, 87% coverage of query (49.7 bits)

PTFAH_VIBCH / Q9KM70 Multiphosphoryl transfer protein; MTP from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 2 papers)
    29% identity, 84% coverage of query (48.5 bits)

Pf1N1B4_1146 fructose-specific PTS system (fructose 1-phosphate forming), EI, Hpr, and EII-A components from Pseudomonas fluorescens FW300-N1B4
    33% identity, 82% coverage of query (46.2 bits)

LicR / VIMSS279545 LicR regulator of Beta-glucosides utilization, effector HPr, phosphocarrier protein; LicB, lichenan-specific enzyme IIB PTS component (activator) from Oceanobacillus iheyensis HTE831
    26% identity, 87% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory