Searching for up to 100 curated homologs for GFF878 FitnessBrowser__Marino:GFF878 (460 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.22.5.3 / Q9KDT3 Neurotransmitter:sodium symporter of 455 aas, MhsT from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
44% identity, 98% coverage of query (331 bits)
6yu6B / Q9KDT3 Crystal structure of mhst in complex with l-leucine (see paper)
45% identity, 96% coverage of query (327 bits)
6yu5A Crystal structure of mhst in complex with l-valine
45% identity, 97% coverage of query (327 bits)
6yu3A Crystal structure of mhst in complex with l-phenylalanine
45% identity, 97% coverage of query (327 bits)
6yu2A Crystal structure of mhst in complex with l-isoleucine
45% identity, 97% coverage of query (327 bits)
4us3A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state
45% identity, 97% coverage of query (327 bits)
6yu7A Crystal structure of mhst in complex with l-tyrosine
45% identity, 97% coverage of query (327 bits)
6yu4A Crystal structure of mhst in complex with l-4f-phenylalanine
45% identity, 97% coverage of query (327 bits)
4us4A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state (lipidic cubic phase form)
45% identity, 95% coverage of query (318 bits)
TC 2.A.22.4.1 / O50649 High affinity tryptophan:Na+ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The Km for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with Ki values of 200 and 440 μM, respectively. An evolutionarily conserved role of adjacent transmembrane segments 7 and 8 has been proposed from Symbiobacterium thermophilum (see 2 papers)
tnaT / BAD39427.1 sodium-and chloride-dependent transporter, TnaT from Symbiobacterium thermophilum IAM 14863 (see paper)
31% identity, 98% coverage of query (184 bits)
TC 2.A.22.5.1 / Q58715 Hypothetical Na+-dependent permease from Methanococcus jannaschii (see paper)
35% identity, 74% coverage of query (168 bits)
TC 2.A.22.5.2 / Q8RHM5 The 11 TMS Na+-dependent tyrosine transporter, Tyt1 from Fusobacterium nucleatum subsp. nucleatum (see paper)
30% identity, 93% coverage of query (161 bits)
Build an alignment for GFF878 and 12 homologs with ≥ 30% identity
Or download the sequences
3gwwA Leucine transporter leut in complex with s-fluoxetine
29% identity, 96% coverage of query (156 bits)
TC 2.A.22.4.2 / O67854 The amino acid (leucine):2 Na+ symporter, LeuTAa (Yamashita et al., 2005). LeuT possesses two ion binding sites, NA1 and NA2, both highly specific for Na+ but with differing mechanisms of binding (Noskov and Roux, 2008). X-ray structures have been determined for LeuT in substrate-free outward-open and apo inward-open states from Aquifex aeolicus (see paper)
29% identity, 97% coverage of query (155 bits)
3f3aA Crystal structure of leut bound to l-tryptophan and sodium
30% identity, 96% coverage of query (155 bits)
3mpnA F177r1 mutant of leut
29% identity, 96% coverage of query (155 bits)
3uslA Crystal structure of leut bound to l-selenomethionine in space group c2 from lipid bicelles
30% identity, 96% coverage of query (155 bits)
3usgA Crystal structure of leut bound to l-leucine in space group c2 from lipid bicelles
30% identity, 96% coverage of query (155 bits)
3gwvA Leucine transporter leut in complex with r-fluoxetine
29% identity, 96% coverage of query (155 bits)
2q6hA / O67854 Crystal structure analysis of leut complexed with l-leucine, sodium, and clomipramine (see paper)
29% identity, 96% coverage of query (154 bits)
TC 2.A.22.4.3 / Q8NRL8 Transporter, component of The methionine/alanine uptake porter, MetPS (Trotschel et al., 2008) (MetP is the transporter; MetS is an essential auxiliary subunit) from Corynebacterium glutamicum
32% identity, 92% coverage of query (154 bits)
2qeiA Crystal structure analysis of leut complexed with l-alanine, sodium, and clomipramine
29% identity, 96% coverage of query (154 bits)
2q72A Crystal structure analysis of leut complexed with l-leucine, sodium, and imipramine
29% identity, 96% coverage of query (154 bits)
3gwuA Leucine transporter leut in complex with sertraline
29% identity, 96% coverage of query (154 bits)
3f4jA Crystal structure of leut bound to glycine and sodium
29% identity, 96% coverage of query (154 bits)
3f3dA Crystal structure of leut bound to l-methionine and sodium
29% identity, 96% coverage of query (154 bits)
3f3cA Crystal structure of leut bound to 4-fluoro-l-phenylalanine and sodium
29% identity, 96% coverage of query (154 bits)
2qb4A Crystal structure analysis of leut complexed with l-leucine, sodium and desipramine
29% identity, 96% coverage of query (154 bits)
3uspA Crystal structure of leut in heptyl-beta-d-selenoglucoside
29% identity, 96% coverage of query (154 bits)
6xwmA Mechanism of substrate release in neurotransmitter:sodium symporters: the structure of leut in an inward-facing occluded conformation
29% identity, 94% coverage of query (147 bits)
4mm7A Crystal structure of leubat (delta13 mutant) in complex with desvenlafaxine
29% identity, 96% coverage of query (146 bits)
4mm4B Crystal structure of leubat (delta13 mutant) in complex with paroxetine
29% identity, 96% coverage of query (146 bits)
4mm4A Crystal structure of leubat (delta13 mutant) in complex with paroxetine
29% identity, 96% coverage of query (146 bits)
4mm6A Crystal structure of leubat (delta13 mutant) in complex with (s)- duloxetine
29% identity, 96% coverage of query (146 bits)
4mm9A Crystal structure of leubat (delta13 mutant) in complex with fluvoxamine
29% identity, 96% coverage of query (146 bits)
4mmeA Crystal structure of leubat (delta6 mutant) in complex with mazindol
29% identity, 96% coverage of query (145 bits)
INE_DROME / Q9VR07 Sodium- and chloride-dependent GABA transporter ine; Protein inebriated; Protein receptor oscillation A from Drosophila melanogaster (Fruit fly) (see 6 papers)
TC 2.A.22.3.12 / Q9VR07 Sodium- and chloride-dependent GABA transporter, Ine (Protein inebriated) (Protein receptor oscillation A) from Drosophila melanogaster (see 10 papers)
27% identity, 75% coverage of query (131 bits)
S6A13_HUMAN / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Homo sapiens (Human) (see 3 papers)
TC 2.A.22.3.10 / Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) from Homo sapiens (see 5 papers)
25% identity, 100% coverage of query (127 bits)
S6A13_MOUSE / P31649 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 13 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.22.3.8 / P31649 Mouse GABA, β-alanine, fluoro-β-alanine and taurine transporter-3 (GAT3) (Liu et al. 1999). Orthologous to rat and human GAT2; 72% identical to GAT4 (2.A.22.3.7) (takes up GABA with high affinity into presynaptic terminals). Also takes up the carnitine precursor, gamma-butyrobetaine from Mus musculus (see 3 papers)
25% identity, 97% coverage of query (122 bits)
S6A13_RAT / P31646 Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 100% coverage of query (122 bits)
SC6A4_MOUSE / Q60857 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Mus musculus (Mouse) (see 10 papers)
27% identity, 72% coverage of query (119 bits)
SC6A4_HUMAN / P31645 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Homo sapiens (Human) (see 20 papers)
TC 2.A.22.1.1 / P31645 Serotonin (5-hydroxytryptamine; 5 HT):Na+:Cl- symporter, SERT-A from Homo sapiens (Human) (see 16 papers)
SLC6A4 / GB|AAW80933.1 sodium-dependent serotonin transporter from Homo sapiens
25% identity, 72% coverage of query (117 bits)
SC6A4_RAT / P31652 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Rattus norvegicus (Rat) (see 13 papers)
27% identity, 72% coverage of query (117 bits)
SC6A4_MACMU / Q9MYX0 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Macaca mulatta (Rhesus macaque) (see paper)
25% identity, 72% coverage of query (117 bits)
SC6A1_RAT / P23978 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Rattus norvegicus (Rat) (see 4 papers)
SC6A1_MOUSE / P31648 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus musculus (Mouse) (see 4 papers)
25% identity, 75% coverage of query (115 bits)
SC6A1_HUMAN / P30531 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Homo sapiens (Human) (see 2 papers)
TC 2.A.22.3.2 / P30531 γ-aminobutyric acid (GABA):Na+:Cl- symporter, GAT-1 (Stoichiometry, GABA:Na+ = 1:2 where both Na+ binding sites, Na1 and Na2, have been identified. Na2 but not Na1 can accommodate Li+ (Zhou et al., 2006)). Cai et al. 2005 have reported that N-glycosylation increases the stability, trafficking and GABA-uptake of GABA transporter 1. Glutamine 291 is essential for Cl- binding (Ben-Yona et al., 2011). Four human isoforms have been identified, GAT-1, GAT-2, GAT-3, and GAT-4, all about 70% identical to each other (Borden et al., 1992). GAT-2 transports γ-aminobutyric acid and β-alanine (Christiansen et al, 2007) It also concentratively takes up β-alanine and α-fluoro-β-alanine (Liu et al., 1999). GAT1 is capable of intracellular Na+-, Cl-- and GABA-induced outward currents (reverse GABA transport; GABA efflux) from Homo sapiens (Human) (see 3 papers)
25% identity, 75% coverage of query (115 bits)
7sk2A / P30531 Human wildtype gaba reuptake transporter 1 in complex with tiagabine, inward-open conformation (see paper)
25% identity, 74% coverage of query (114 bits)
TC 2.A.22.2.8 / Q6VS78 Cation-dependent nutrient amino acid transporter, AAT1 (L-phe > cys > his > ala > ser > met > ile > tyr > D-phe > thr > gly) from Aedes aegypti (Yellowfever mosquito)
26% identity, 72% coverage of query (114 bits)
SC6A4_CAVPO / O35899 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Cavia porcellus (Guinea pig) (see paper)
26% identity, 72% coverage of query (114 bits)
6awnA / P31645 X-ray structure of the s439t human serotonin transporter complexed with paroxetine at the central site (see paper)
25% identity, 72% coverage of query (114 bits)
5i74A X-ray structure of the ts3 human serotonin transporter complexed with br-citalopram at the central site
25% identity, 72% coverage of query (114 bits)
5i71A X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site
25% identity, 72% coverage of query (114 bits)
6awpA X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
25% identity, 72% coverage of query (114 bits)
6awoA X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
25% identity, 72% coverage of query (114 bits)
5i6xA X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site
25% identity, 72% coverage of query (114 bits)
7txtS Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and nacl
25% identity, 71% coverage of query (113 bits)
7lwdA Cryo-em structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15b8 fab
25% identity, 71% coverage of query (113 bits)
6vrlA Cryo-em structure of the wild-type human serotonin transporter complexed with i-paroxetine and 8b6 fab
25% identity, 71% coverage of query (113 bits)
6vrkA Cryo-em structure of the wild-type human serotonin transporter complexed with br-paroxetine and 8b6 fab
25% identity, 71% coverage of query (113 bits)
6dzvA Wild type human serotonin transporter in complex with 15b8 fab bound to ibogaine in occluded conformation
25% identity, 71% coverage of query (113 bits)
7li9A 5-ht bound serotonin transporter reconstituted in lipid nanodisc in kcl
25% identity, 71% coverage of query (113 bits)
TC 2.A.22.2.5 / O76188 Gut epithelium absorptive neutral amino acid, K+- and Na+-dependent transporter KAAT1 (electrogenic; Cl--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro from Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) (see paper)
25% identity, 73% coverage of query (112 bits)
8gnkA Cryoem structure of cytosol-facing, substrate-bound ratgat1
25% identity, 73% coverage of query (112 bits)
SC6A3_BOVIN / P27922 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Bos taurus (Bovine) (see paper)
26% identity, 75% coverage of query (111 bits)
8de4A Native serotonin transporter in complex with 15b8 fab in the presence of methamphetamine
25% identity, 71% coverage of query (111 bits)
8de3A Native serotonin transporter in complex with 15b8 fab antibody in the presence of cocaine
25% identity, 71% coverage of query (111 bits)
7y7wA Cryo-em structure of human gaba transporter gat1 bound with gaba in nacl solution in an inward-occluded state at 2.4 angstrom
25% identity, 73% coverage of query (111 bits)
SNF3_CAEEL / G5EBN9 Sodium- and chloride-dependent betaine transporter; Betaine transporter SNF-3; Na(+)/Cl(-) betaine/GABA transporter; Sodium:neurotransmitter symporter family protein 3 from Caenorhabditis elegans (see 2 papers)
22% identity, 80% coverage of query (110 bits)
SC6A4_DROME / P51905 Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Cocaine-sensitive serotonin transporter; dSERT1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
TC 2.A.22.1.9 / P51905 The sodium-dependent serotonin transporter of 622 aas and 12 TMSs, SERT or SerT from Drosophila melanogaster
26% identity, 73% coverage of query (110 bits)
SC6A4_BOVIN / Q9XT49 Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 from Bos taurus (Bovine) (see paper)
25% identity, 72% coverage of query (110 bits)
SC6A1_MUSCO / P48057 Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 from Mus cookii (Cook's mouse) (see paper)
24% identity, 75% coverage of query (109 bits)
S6A12_MOUSE / P31651 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 12 from Mus musculus (Mouse) (see paper)
24% identity, 74% coverage of query (108 bits)
SC6A3_RAT / P23977 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Rattus norvegicus (Rat) (see 6 papers)
25% identity, 76% coverage of query (108 bits)
TC 2.A.22.2.9 / B2ZXL8 The densovirus type-2 (BmDNV-2) receptor; putative amino acid transporter, the densonucleosis refractoriness, Nsd-2 protein, of 625 aas and 11-12 TMSs (Abe et al. 2000). Deletion of the nsd2 gene, encoding this transporter in the midgut membrane, causes resistance to this parvo-like virus as well as bidensovirus from Bombyx mori (see paper)
25% identity, 70% coverage of query (108 bits)
7y7yA Cryo-em structure of human gaba transporter gat1 bound with nipecotic acid in nacl solution in an inward-occluded state at 2.4 angstrom
25% identity, 73% coverage of query (108 bits)
TC 2.A.22.2.4 / Q9U5A9 Gut epithelium absorptive neutral amino acid Na+- or K+-dependent transporter, CAATCH1 (electrogenic; Cl--independent. Substrates: L-proline-preferring + Na+; L-threonine-preferring + K+; also transports L-methionine) (CAATCH1 can also function as an amino acid-gated cation [Na+ and K+] channel.) from Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) (see paper)
25% identity, 73% coverage of query (107 bits)
SC6A3_HUMAN / Q01959 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Homo sapiens (Human) (see 10 papers)
TC 2.A.22.1.3 / Q01959 Dopamine:Na+ symporter, DAT (also takes up amphetamines in symport with Na+ which promotes intracellular Na+-dependent dopamine efflux (Khoshbouei et al., 2003)). It is inhibited by cocaine, amphetamines, neurotoxins, antidepressants and ethanol (Chen et al., 2004)]. Zn2+ potentiates uncoupled Cl- conductance from Homo sapiens (Human) (see 16 papers)
SLC6A3 / GB|ABO77644.1 sodium-dependent dopamine transporter from Homo sapiens (see paper)
25% identity, 77% coverage of query (107 bits)
S6A11_RAT / P31647 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11 from Rattus norvegicus (Rat) (see 3 papers)
24% identity, 72% coverage of query (107 bits)
S6A11_MOUSE / P31650 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Sodium- and chloride-dependent GABA transporter 4; GAT-4; Solute carrier family 6 member 11 from Mus musculus (Mouse) (see 2 papers)
TC 2.A.22.3.7 / Q8BWA7 The GABA transporter, GAT4 (single mutations render this transporter C1- independent) from Mus musculus (see 2 papers)
24% identity, 72% coverage of query (107 bits)
S6A11_HUMAN / P48066 Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.9 / P48066 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11). Expression of GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, and a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people as well. Thus, impaired GABA clearance within the amygdala contributes to alcohol addiction from Homo sapiens (see 2 papers)
24% identity, 72% coverage of query (107 bits)
SC6A3_MOUSE / Q61327 Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3 from Mus musculus (Mouse) (see 6 papers)
24% identity, 77% coverage of query (107 bits)
S6A12_HUMAN / P48065 Sodium- and chloride-dependent betaine transporter; BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12 from Homo sapiens (Human) (see paper)
TC 2.A.22.3.1 / P48065 Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order) from Homo sapiens (Human) (see 5 papers)
24% identity, 74% coverage of query (105 bits)
6m38A X-ray structure of a drosophila dopamine transporter with subsiteb mutations (d121g/s426m) in s-duloxetine bound form
25% identity, 76% coverage of query (105 bits)
6m3zA X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in milnacipran bound form
25% identity, 76% coverage of query (105 bits)
6m0zA X-ray structure of drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in l-norepinephrine bound form
25% identity, 76% coverage of query (105 bits)
6m47A X-ray structure of a drosophila dopamine transporter with net-like mutations (d121g/s426m/f471l) in tramadol bound form
25% identity, 76% coverage of query (105 bits)
7wlwA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with skf89976a
25% identity, 76% coverage of query (105 bits)
7wgtA X-ray structure of thermostabilized drosophila dopamine transporter with gaba transporter1-like substitutions in the binding site, in complex with no711.
25% identity, 76% coverage of query (105 bits)
4xp9C / Q7K4Y6 X-ray structure of drosophila dopamine transporter bound to psychostimulant d-amphetamine (see paper)
25% identity, 76% coverage of query (104 bits)
SC6A2_BOVIN / P51143 Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 from Bos taurus (Bovine) (see paper)
23% identity, 77% coverage of query (104 bits)
4xnxA X-ray structure of drosophila dopamine transporter in complex with reboxetine
25% identity, 76% coverage of query (104 bits)
4xpfA X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to rti-55
25% identity, 76% coverage of query (104 bits)
4xpaA X-ray structure of drosophila dopamine transporter bound to 3, 4dichlorophenethylamine
25% identity, 76% coverage of query (104 bits)
4xp6A X-ray structure of drosophila dopamine transporter bound to psychostimulant methamphetamine
25% identity, 76% coverage of query (104 bits)
4xp5A X-ray structure of drosophila dopamine transporter bound to cocaine analogue-rti55
25% identity, 76% coverage of query (104 bits)
4xp4A X-ray structure of drosophila dopamine transporter in complex with cocaine
25% identity, 76% coverage of query (104 bits)
4xp1A X-ray structure of drosophila dopamine transporter bound to neurotransmitter dopamine
25% identity, 76% coverage of query (104 bits)
TC 2.A.22.1.6 / E9LD23 The dopamine/norepinephrine transporter (SmDAT) from Schistosoma mansoni
24% identity, 79% coverage of query (103 bits)
S6A12_CANLF / P27799 Sodium- and chloride-dependent betaine transporter; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12 from Canis lupus familiaris (Dog) (Canis familiaris) (see 3 papers)
24% identity, 74% coverage of query (103 bits)
SC6A5_MOUSE / Q761V0 Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5 from Mus musculus (Mouse) (see paper)
TC 2.A.22.2.6 / Q761V0 Glycine:Na+ transporter, GlyT2b (glycine/3Na+/1Cl- symporter, SLC6A5) (see paper)
26% identity, 74% coverage of query (102 bits)
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