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Searching for up to 100 curated homologs for GFF926 PGA1_c09420 pyruvate carboxylase Pyc (1188 a.a.)

Found high-coverage hits (≥70%) to 39 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q2K340 pyruvate carboxylase (EC 6.4.1.1) from Rhizobium etli (see 8 papers)
    65% identity, 96% coverage of query (1524 bits)

3tw6B / Q2K340 Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a (see paper)
    64% identity, 96% coverage of query (1483 bits)

3tw6C Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a
    64% identity, 89% coverage of query (1382 bits)

2qf7A / Q2K340 Crystal structure of a complete multifunctional pyruvate carboxylase from rhizobium etli (see paper)
    61% identity, 96% coverage of query (1375 bits)

2qf7B / Q2K340 Crystal structure of a complete multifunctional pyruvate carboxylase from rhizobium etli (see paper)
    63% identity, 89% coverage of query (1341 bits)

3tw6A Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a
    61% identity, 89% coverage of query (1309 bits)

PYC_BACSU / Q9KWU4 Pyruvate carboxylase; Pyruvic carboxylase; PYC; EC 6.4.1.1 from Bacillus subtilis (strain 168) (see 2 papers)
    53% identity, 96% coverage of query (1258 bits)

7zz3A Cryo-em structure of "bc react" conformation of lactococcus lactis pyruvate carboxylase with acetyl-coa
    53% identity, 96% coverage of query (1203 bits)

5vyzA Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
    53% identity, 96% coverage of query (1202 bits)

A1ANN6 biotin carboxylase (EC 6.3.4.14) from Pelobacter propionicus (see paper)
    53% identity, 96% coverage of query (1191 bits)

A5G5L1 biotin carboxylase (EC 6.3.4.14) from Geotalea uraniireducens (see paper)
    53% identity, 96% coverage of query (1184 bits)

PYC_STAAM / A0A0H3JRU9 Pyruvate carboxylase; EC 6.4.1.1 from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 3 papers)
A0A0H3JRU9 pyruvate carboxylase (EC 6.4.1.1) from Staphylococcus aureus (see 4 papers)
    51% identity, 96% coverage of query (1177 bits)

3bg5A / A0A0H3JRU9 Crystal structure of staphylococcus aureus pyruvate carboxylase (see paper)
    51% identity, 96% coverage of query (1154 bits)

3hb9A Crystal structure of s. Aureus pyruvate carboxylase a610t mutant
    50% identity, 96% coverage of query (1138 bits)

7zyyA Cryo-em structure of lactococcus lactis pyruvate carboxylase with acetyl-coa
    54% identity, 89% coverage of query (1134 bits)

PYC1_CAEEL / O17732 Pyruvate carboxylase 1; Pyruvic carboxylase 1; PCB 1; EC 6.4.1.1 from Caenorhabditis elegans (see paper)
O17732 pyruvate carboxylase (EC 6.4.1.1) from Caenorhabditis elegans (see paper)
    50% identity, 96% coverage of query (1113 bits)

5vyzC Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
    51% identity, 96% coverage of query (1109 bits)

7wtbB / P11498 Cryo-em structure of human pyruvate carboxylase with acetyl-coa (see paper)
    50% identity, 96% coverage of query (1094 bits)

7wtdC Cryo-em structure of human pyruvate carboxylase with acetyl-coa in the intermediate state 1
    50% identity, 96% coverage of query (1094 bits)

PC / P11498 pyruvate carboxylase, mitochondrial (EC 6.4.1.1) from Homo sapiens (see 5 papers)
PYC_HUMAN / P11498 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Homo sapiens (Human) (see 5 papers)
P11498 pyruvate carboxylase (EC 6.4.1.1) from Homo sapiens (see 5 papers)
    50% identity, 96% coverage of query (1093 bits)

Q29RK2 pyruvate carboxylase (EC 6.4.1.1) from Bos taurus (see paper)
    50% identity, 96% coverage of query (1089 bits)

PYC_MOUSE / Q05920 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Mus musculus (Mouse) (see paper)
    50% identity, 96% coverage of query (1081 bits)

PYC2_YEAST / P32327 Pyruvate carboxylase 2; Pyruvic carboxylase 2; PCB 2; EC 6.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32327 pyruvate carboxylase (EC 6.4.1.1) from Saccharomyces cerevisiae (see paper)
    47% identity, 97% coverage of query (1056 bits)

PYC1_YEAST / P11154 Pyruvate carboxylase 1; Pyruvic carboxylase 1; PCB 1; EC 6.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P11154 pyruvate carboxylase (EC 6.4.1.1) from Saccharomyces cerevisiae (see 2 papers)
    48% identity, 97% coverage of query (1051 bits)

8gk8A R21a staphylococcus aureus pyruvate carboxylase
    50% identity, 89% coverage of query (1038 bits)

pycA putative pyruvate carboxylase or glutathione synthase from Emericella nidulans (see paper)
    47% identity, 96% coverage of query (1027 bits)

pyr1 / RF|NP_595900.1 pyruvate carboxylase Pyr1; EC 6.4.1.1 from Schizosaccharomyces pombe (see paper)
    46% identity, 97% coverage of query (1010 bits)

PYC / O93918 pyruvate carboxylase monomer (EC 6.4.1.1) from Aspergillus terreus (see paper)
    46% identity, 96% coverage of query (1009 bits)

4qshC Crystal structure of l. Monocytogenes pyruvate carboxylase in complex with cyclic-di-amp (see paper)
    53% identity, 80% coverage of query (1004 bits)

B9X0T8 pyruvate carboxylase (EC 6.4.1.1) from Emiliania huxleyi (see paper)
    47% identity, 97% coverage of query (984 bits)

A0QV14 pyruvate carboxylase (EC 6.4.1.1) from Mycolicibacterium smegmatis (see paper)
    48% identity, 96% coverage of query (980 bits)

pycA / Q9F843 pyruvate carboxylase subunit (EC 6.4.1.1) from Mycolicibacterium smegmatis (see paper)
    48% identity, 96% coverage of query (976 bits)

3bg5B / A0A0H3JRU9 Crystal structure of staphylococcus aureus pyruvate carboxylase (see paper)
    51% identity, 79% coverage of query (958 bits)

5vywA Crystal structure of lactococcus lactis pyruvate carboxylase
    54% identity, 72% coverage of query (937 bits)

4hnvB / A0A0H3JRU9 Crystal structure of r54e mutant of s. Aureus pyruvate carboxylase (see paper)
    49% identity, 79% coverage of query (887 bits)

8gk8C R21a staphylococcus aureus pyruvate carboxylase
    51% identity, 72% coverage of query (884 bits)

3ho8A Crystal structure of s. Aureus pyruvate carboxylase in complex with coenzyme a
    51% identity, 72% coverage of query (884 bits)

3ho8D / A0A0H3JRU9 Crystal structure of s. Aureus pyruvate carboxylase in complex with coenzyme a (see paper)
    48% identity, 72% coverage of query (798 bits)

8gk8D R21a staphylococcus aureus pyruvate carboxylase
    48% identity, 72% coverage of query (783 bits)

Build an alignment

Build an alignment for GFF926 and 39 homologs with ≥ 30% identity

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory