Searching for up to 100 curated homologs for GFF948 FitnessBrowser__Marino:GFF948 (240 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
44% identity, 95% coverage of query (179 bits)
LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
38% identity, 95% coverage of query (160 bits)
Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
38% identity, 100% coverage of query (155 bits)
HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
40% identity, 95% coverage of query (154 bits)
TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
35% identity, 95% coverage of query (154 bits)
Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
38% identity, 95% coverage of query (152 bits)
AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
38% identity, 95% coverage of query (152 bits)
TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
38% identity, 95% coverage of query (152 bits)
braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
39% identity, 95% coverage of query (152 bits)
TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
39% identity, 95% coverage of query (149 bits)
TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
40% identity, 95% coverage of query (149 bits)
TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
36% identity, 95% coverage of query (148 bits)
TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
36% identity, 95% coverage of query (142 bits)
TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
35% identity, 92% coverage of query (141 bits)
TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
39% identity, 92% coverage of query (132 bits)
TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
39% identity, 91% coverage of query (125 bits)
Build an alignment for GFF948 and 16 homologs with ≥ 30% identity
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E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
27% identity, 95% coverage of query (114 bits)
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
31% identity, 95% coverage of query (113 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
28% identity, 95% coverage of query (112 bits)
Pf6N2E2_5405 ABC transporter for D-Alanine, ATPase component from Pseudomonas fluorescens FW300-N2E2
31% identity, 90% coverage of query (109 bits)
lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
31% identity, 93% coverage of query (109 bits)
TC 3.A.1.3.7 / Q52666 BztD, component of Glutamate/glutamine/aspartate/asparagine porter from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
31% identity, 90% coverage of query (109 bits)
YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
32% identity, 91% coverage of query (109 bits)
A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
30% identity, 95% coverage of query (109 bits)
SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
30% identity, 90% coverage of query (107 bits)
GLUA_CORGL / P48243 Glutamate transport ATP-binding protein GluA; Glutamate uptake system protein GluA; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
32% identity, 95% coverage of query (105 bits)
LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
31% identity, 91% coverage of query (105 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
31% identity, 95% coverage of query (105 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
31% identity, 91% coverage of query (105 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
31% identity, 91% coverage of query (105 bits)
TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
30% identity, 91% coverage of query (104 bits)
PP_3597 L-lysine and D-lysine ABC transporter, ATPase component from Pseudomonas putida KT2440
31% identity, 88% coverage of query (104 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
31% identity, 91% coverage of query (103 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 89% coverage of query (103 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 91% coverage of query (102 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
30% identity, 95% coverage of query (102 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
30% identity, 95% coverage of query (102 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
30% identity, 93% coverage of query (101 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
28% identity, 91% coverage of query (89.0 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
28% identity, 91% coverage of query (88.6 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 88% coverage of query (84.7 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
29% identity, 88% coverage of query (84.7 bits)
2olkA Abc protein artp in complex with adp-beta-s
29% identity, 88% coverage of query (84.7 bits)
2oljA Abc protein artp in complex with adp/mg2+
29% identity, 88% coverage of query (84.7 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
28% identity, 88% coverage of query (83.2 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
29% identity, 85% coverage of query (83.2 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
25% identity, 96% coverage of query (81.6 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
27% identity, 93% coverage of query (81.3 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
28% identity, 84% coverage of query (80.1 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
28% identity, 88% coverage of query (79.3 bits)
7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
27% identity, 85% coverage of query (79.0 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
27% identity, 84% coverage of query (78.6 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
27% identity, 84% coverage of query (78.6 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
27% identity, 84% coverage of query (78.6 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
24% identity, 96% coverage of query (78.6 bits)
4s0fA Crystal structure of the peptidase-containing abc transporter pcat1 e648q mutant complexed with atpgs in an occluded conformation
26% identity, 85% coverage of query (77.4 bits)
5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
29% identity, 82% coverage of query (77.0 bits)
7roqA / O95477 Alternative structure of human abca1
28% identity, 80% coverage of query (77.0 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
31% identity, 83% coverage of query (76.6 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
27% identity, 80% coverage of query (76.3 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
25% identity, 95% coverage of query (75.9 bits)
7n59A / Q9LVM1 Structure of atatm3 in the inward-facing conformation with gssg bound (see paper)
28% identity, 93% coverage of query (75.9 bits)
AB25B_ARATH / Q9LVM1 ABC transporter B family member 25, mitochondrial; ABC transporter ABCB.25; AtABCB25; ABC transporter of the mitochondrion 3; AtATM3; Iron-sulfur clusters transporter ATM3; Protein STARIK 1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.210.8 / Q9LVM1 Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively from Arabidopsis thaliana (Mouse-ear cress) (see 11 papers)
GB|AAN13224.1 putative ABC transporter protein from Arabidopsis thaliana (see paper)
28% identity, 93% coverage of query (75.9 bits)
7n5aA Structure of atatm3 in the closed conformation
28% identity, 93% coverage of query (75.5 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
27% identity, 80% coverage of query (75.5 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
27% identity, 76% coverage of query (74.7 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
26% identity, 80% coverage of query (74.7 bits)
2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
30% identity, 88% coverage of query (74.7 bits)
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
30% identity, 88% coverage of query (74.7 bits)
pglK / Q0P9C4 ABC-type undecaprenyldiphosphate-linked heptasaccharide transporter monomer from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 2 papers)
PGLK_CAMJE / Q0P9C4 Protein glycosylation K; EC 7.5.2.5 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 3 papers)
TC 3.A.1.106.15 / Q0P9C4 Lipid flippase, PglK or WlaB, of 564 aas and 6 N-terminal TMSs with a C-terminal ATPase domain from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
25% identity, 88% coverage of query (74.3 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
28% identity, 89% coverage of query (73.6 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
28% identity, 89% coverage of query (73.6 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
25% identity, 83% coverage of query (73.2 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
28% identity, 89% coverage of query (73.2 bits)
6hrcB Outward-facing pglk with atpgammas bound
25% identity, 88% coverage of query (72.8 bits)
6hrcA / O86150 Outward-facing pglk with atpgammas bound (see paper)
25% identity, 88% coverage of query (72.8 bits)
5nbdA Pglk flippase in complex with inhibitory nanobody
25% identity, 88% coverage of query (72.8 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
28% identity, 89% coverage of query (72.8 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
27% identity, 89% coverage of query (72.8 bits)
Q00748 Multidrug resistance protein homolog 65; P-glycoprotein 65; EC 7.6.2.2 from Drosophila melanogaster (Fruit fly)
28% identity, 89% coverage of query (72.0 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
25% identity, 79% coverage of query (71.6 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
24% identity, 92% coverage of query (71.6 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
29% identity, 96% coverage of query (71.6 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
27% identity, 89% coverage of query (71.2 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
26% identity, 79% coverage of query (71.2 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
29% identity, 87% coverage of query (71.2 bits)
6s7pA Nucleotide bound abcb4
29% identity, 87% coverage of query (70.9 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
26% identity, 79% coverage of query (70.9 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
29% identity, 86% coverage of query (70.9 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
26% identity, 79% coverage of query (70.9 bits)
7lkpA Structure of atp-free human abca4
26% identity, 79% coverage of query (70.9 bits)
7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8)
29% identity, 85% coverage of query (69.7 bits)
7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4)
29% identity, 85% coverage of query (69.7 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
29% identity, 81% coverage of query (69.7 bits)
7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
29% identity, 85% coverage of query (69.7 bits)
8ipsA / P23886 Cryo-em structure of heme transporter cyddc from escherichia coli in the inward facing heme loading state (see paper)
29% identity, 85% coverage of query (69.7 bits)
7lkzA Structure of atp-bound human abca4
25% identity, 79% coverage of query (69.7 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
29% identity, 80% coverage of query (69.7 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
25% identity, 79% coverage of query (69.7 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
25% identity, 84% coverage of query (69.3 bits)
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Lawrence Berkeley National Laboratory