Searching for up to 100 curated homologs for GFF974 FitnessBrowser__Marino:GFF974 (552 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ILVX_MYCTU / O53554 Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O53554 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
53% identity, 93% coverage of query (492 bits)
Build an alignment for GFF974 and 1 homologs with ≥ 30% identity
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6a50A Structure of benzoylformate decarboxylases in complex with cofactor tpp
28% identity, 90% coverage of query (145 bits)
mdlC / P20906 MdlC (EC 4.1.1.7) from Pseudomonas putida (see 2 papers)
P20906 benzoylformate decarboxylase (EC 4.1.1.7) from Pseudomonas putida (see 16 papers)
28% identity, 90% coverage of query (141 bits)
3fznA Intermediate analogue in benzoylformate decarboxylase
28% identity, 90% coverage of query (141 bits)
1bfdA Benzoylformate decarboxylase from pseudomonas putida
28% identity, 90% coverage of query (141 bits)
3f6bX Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor paa
28% identity, 90% coverage of query (141 bits)
5deiA Benzoylformate decarboxylase from pseudomonas putida
28% identity, 90% coverage of query (141 bits)
3fsjX Crystal structure of benzoylformate decarboxylase in complex with the inhibitor mbp
28% identity, 90% coverage of query (141 bits)
1mczA Benzoylformate decarboxylase from pseudomonas putida complexed with an inhibitor, r-mandelate
28% identity, 90% coverage of query (141 bits)
1pi3A E28q mutant benzoylformate decarboxylase from pseudomonas putida
28% identity, 90% coverage of query (140 bits)
dpgB / A3RJV5 benzoylformate decarboxylase monomer (EC 4.1.1.7) from Stutzerimonas stutzeri (see paper)
29% identity, 90% coverage of query (138 bits)
6qsiA / Q4KB02 Pseudomonas fluorescens pf-5 thiamine diphosphate-dependent 4- hydroxybenzoylformate decarboxylase (see paper)
27% identity, 92% coverage of query (129 bits)
bfd / CAK95977.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
29% identity, 92% coverage of query (114 bits)
bfd / CAK95976.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
29% identity, 92% coverage of query (112 bits)
Q836A5 acetolactate synthase (EC 2.2.1.6) from Enterococcus faecalis (see 2 papers)
25% identity, 92% coverage of query (112 bits)
4q9dB / A0QSU7 X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from mycobacterium smegmatis (see paper)
25% identity, 90% coverage of query (110 bits)
Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus (see paper)
25% identity, 93% coverage of query (100 bits)
4k9qA / A4SXU0 The crystal structure of benzoylformate decarboxylase from polynucleobacter necessarius
25% identity, 91% coverage of query (99.4 bits)
ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
25% identity, 91% coverage of query (98.2 bits)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium
25% identity, 95% coverage of query (97.4 bits)
5k2oA / P17597 Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
25% identity, 95% coverage of query (97.1 bits)
ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana (see 8 papers)
25% identity, 95% coverage of query (97.1 bits)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium
25% identity, 95% coverage of query (97.1 bits)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron
25% identity, 95% coverage of query (96.7 bits)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
25% identity, 95% coverage of query (96.7 bits)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium
25% identity, 95% coverage of query (96.7 bits)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
25% identity, 95% coverage of query (96.7 bits)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin
25% identity, 95% coverage of query (96.7 bits)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
25% identity, 95% coverage of query (96.7 bits)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
25% identity, 95% coverage of query (96.7 bits)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
25% identity, 95% coverage of query (96.7 bits)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
25% identity, 95% coverage of query (96.7 bits)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl
25% identity, 95% coverage of query (96.7 bits)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
26% identity, 95% coverage of query (96.7 bits)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester
25% identity, 95% coverage of query (96.7 bits)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron
25% identity, 95% coverage of query (96.7 bits)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
25% identity, 95% coverage of query (95.1 bits)
ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
24% identity, 93% coverage of query (94.0 bits)
Q42768 acetolactate synthase (EC 2.2.1.6) from Gossypium hirsutum (see paper)
25% identity, 95% coverage of query (93.2 bits)
IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
24% identity, 93% coverage of query (90.9 bits)
1ovmA / P23234 Crystal structure of indolepyruvate decarboxylase from enterobacter cloacae (see paper)
27% identity, 93% coverage of query (89.7 bits)
Q5VB44 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
24% identity, 95% coverage of query (89.0 bits)
Q5VB49 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
24% identity, 95% coverage of query (88.6 bits)
ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
25% identity, 93% coverage of query (88.6 bits)
Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
24% identity, 94% coverage of query (87.8 bits)
6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
23% identity, 93% coverage of query (87.4 bits)
Q5VB42 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus (see paper)
23% identity, 95% coverage of query (87.0 bits)
ipdC / P23234 indole-3-pyruvate decarboxylase subunit (EC 4.1.1.74) from Enterobacter cloacae (see 2 papers)
DCIP_ENTCL / P23234 Indole-3-pyruvate decarboxylase; Indolepyruvate decarboxylase; EC 4.1.1.74 from Enterobacter cloacae (see paper)
P23234 indolepyruvate decarboxylase (EC 4.1.1.74) from Enterobacter cloacae (see paper)
27% identity, 93% coverage of query (87.0 bits)
SYNPCC7002_A2770 / B1XMM5 2-oxoglutarate decarboxylase monomer (EC 4.1.1.71) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see 2 papers)
B1XMM5 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Synechococcus sp. PCC 7002 (see paper)
24% identity, 94% coverage of query (86.7 bits)
6vz8D / P17597 Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
24% identity, 93% coverage of query (85.5 bits)
P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
24% identity, 94% coverage of query (83.6 bits)
KDC_MYCTU / P9WG37 Alpha-keto-acid decarboxylase; KDC; EC 4.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG37 branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Mycobacterium tuberculosis (see paper)
26% identity, 80% coverage of query (82.4 bits)
6wo1A / Q96VZ6 Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
23% identity, 91% coverage of query (81.6 bits)
1y9dD / P37063 Pyruvate oxidase variant v265a from lactobacillus plantarum (see paper)
24% identity, 92% coverage of query (79.3 bits)
P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
24% identity, 89% coverage of query (79.0 bits)
4feeA High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal b (see paper)
23% identity, 92% coverage of query (77.8 bits)
A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
23% identity, 93% coverage of query (77.4 bits)
P37063 pyruvate oxidase (EC 1.2.3.3) from Lactiplantibacillus plantarum (see 2 papers)
23% identity, 92% coverage of query (77.4 bits)
1powA The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from lactobacillus plantarum
23% identity, 92% coverage of query (77.4 bits)
2ezuA Pyruvate oxidase variant f479w in complex with reaction intermediate 2-acetyl-thiamin diphosphate
23% identity, 92% coverage of query (77.0 bits)
2ez9A Pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate
23% identity, 92% coverage of query (77.0 bits)
2ez8A Pyruvate oxidase variant f479w in complex with reaction intermediate 2-lactyl-thiamin diphosphate
23% identity, 92% coverage of query (77.0 bits)
2ez4B Pyruvate oxidase variant f479w
23% identity, 92% coverage of query (77.0 bits)
pdc / Q5NYJ8 phenylpyruvate decarboxylase (EC 4.1.1.43) from Aromatoleum aromaticum (strain EbN1) (see 2 papers)
26% identity, 95% coverage of query (76.6 bits)
Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
23% identity, 94% coverage of query (76.6 bits)
kivD / Q684J7 α-ketoisovalerate decarboxylase subunit (EC 4.1.1.72) from Lactococcus lactis subsp. lactis (see 2 papers)
Q684J7 pyruvate decarboxylase (EC 4.1.1.1); branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Lactococcus lactis subsp. lactis (see 6 papers)
23% identity, 91% coverage of query (75.1 bits)
Q5M4L0 acetolactate synthase (EC 2.2.1.6) from Streptococcus thermophilus (see paper)
23% identity, 93% coverage of query (74.7 bits)
ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
25% identity, 81% coverage of query (74.7 bits)
als / Q7DAV2 α-acetolactate synthase subunit (EC 2.2.1.6) from Lactococcus lactis subsp. lactis (strain IL1403) (see 2 papers)
Q7DAV2 acetolactate synthase (EC 2.2.1.6) from Lactococcus lactis (see paper)
22% identity, 92% coverage of query (74.7 bits)
Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
25% identity, 93% coverage of query (74.7 bits)
2vbfB / Q6QBS4 The holostructure of the branched-chain keto acid decarboxylase (kdca) from lactococcus lactis (see paper)
23% identity, 80% coverage of query (74.3 bits)
4qq8C / Q9F4L3 Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
24% identity, 91% coverage of query (74.3 bits)
2vbgA The complex structure of the branched-chain keto acid decarboxylase (kdca) from lactococcus lactis with 2r-1-hydroxyethyl-deazathdp
23% identity, 80% coverage of query (74.3 bits)
6vgsBBB / A0A0B8QZ66 6vgsBBB (see paper)
23% identity, 91% coverage of query (73.9 bits)
xsc / Q93PS3 sulfoacetaldehyde acetyltransferase subunit (EC 2.3.3.15) from Desulfonispora thiosulfatigenes (see 2 papers)
23% identity, 93% coverage of query (73.6 bits)
A5X300 acetolactate synthase (EC 2.2.1.6) from Oryza sativa Indica Group (see paper)
23% identity, 95% coverage of query (73.6 bits)
A0A0M3TGF7 acetolactate synthase (EC 2.2.1.6) from Poa annua (see paper)
24% identity, 95% coverage of query (72.4 bits)
V5Q0Z4 acetolactate synthase (EC 2.2.1.6) from Myosoton aquaticum (see paper)
23% identity, 95% coverage of query (72.0 bits)
3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp
24% identity, 91% coverage of query (71.6 bits)
Q92345 Probable pyruvate decarboxylase C1F8.07c; EC 4.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
23% identity, 93% coverage of query (68.2 bits)
5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
23% identity, 92% coverage of query (67.0 bits)
2vbiA / Q8L388 Holostructure of pyruvate decarboxylase from acetobacter pasteurianus
24% identity, 93% coverage of query (66.6 bits)
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
23% identity, 92% coverage of query (65.5 bits)
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
23% identity, 92% coverage of query (65.1 bits)
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
23% identity, 92% coverage of query (65.1 bits)
8i01A / P0AEP7 Crystal structure of escherichia coli glyoxylate carboligase
23% identity, 90% coverage of query (63.9 bits)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
23% identity, 90% coverage of query (63.2 bits)
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
23% identity, 90% coverage of query (63.2 bits)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
23% identity, 90% coverage of query (62.4 bits)
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
23% identity, 90% coverage of query (62.4 bits)
7pt1A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with substrate 2-hib-coa and inactive cofactor 3-deaza-thdp
25% identity, 84% coverage of query (62.4 bits)
7pt4B / P0DUV9 Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
25% identity, 84% coverage of query (62.0 bits)
7pt4A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone
25% identity, 84% coverage of query (62.0 bits)
HACL_ACTC0 / P0DUV9 2-hydroxyacyl-CoA lyase; AcHACL; HACL; 2-hydroxyisobutyryl-CoA lyase; EC 4.1.-.- from Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / CCTCC AA 205017 / NBRC 104400 / YIM 0006) (see 2 papers)
25% identity, 84% coverage of query (62.0 bits)
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
22% identity, 92% coverage of query (60.5 bits)
5npuA Inferred ancestral pyruvate decarboxylase (see paper)
23% identity, 92% coverage of query (58.5 bits)
2ihvA / Q9LCV9 Carboxyethylarginine synthase from streptomyces clavuligerus: 5- guanidinovaleric acid complex (see paper)
20% identity, 87% coverage of query (57.8 bits)
ceaS / Q9LCV9 N2-(carboxyethyl)arginine synthase subunit (EC 2.5.1.66) from Streptomyces clavuligerus (see paper)
CEAS_STRCL / Q9LCV9 N(2)-(2-carboxyethyl)arginine synthase; CEA synthetase; CEAS; EC 2.5.1.66 from Streptomyces clavuligerus (see 3 papers)
21% identity, 87% coverage of query (57.8 bits)
2ihuA Carboxyethylarginine synthase from streptomyces clavuligerus: putative reaction intermediate complex
20% identity, 87% coverage of query (57.8 bits)
2ihuC Carboxyethylarginine synthase from streptomyces clavuligerus: putative reaction intermediate complex
20% identity, 87% coverage of query (57.8 bits)
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