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Searching for up to 100 curated homologs for Ga0059261_0531 FitnessBrowser__Korea:Ga0059261_0531 (389 a.a.)

Found high-coverage hits (≥70%) to 48 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pobA / AAA73519.1 4-hydroxybenzoate hydroxylase from Rhizobium leguminosarum (see paper)
    60% identity, 99% coverage of query (469 bits)

1pbcA Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate, 2,4-dihydroxybenzoate and 2-hydroxy- 4-aminobenzoate and of the try222ala mutant, complexed with 2- hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
    60% identity, 99% coverage of query (465 bits)

pobA / P00438 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas fluorescens (see 2 papers)
PHHY_PSEFL / P00438 p-hydroxybenzoate hydroxylase; PHBH; PHBHase; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas fluorescens (see 13 papers)
    60% identity, 99% coverage of query (464 bits)

2phhA The coenzyme analogue adenosine 5-diphosphoribose displaces fad in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation
    60% identity, 99% coverage of query (464 bits)

1pdhA Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified fad present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin
    60% identity, 99% coverage of query (464 bits)

1bf3A P-hydroxybenzoate hydroxylase (phbh) mutant with cys 116 replaced by ser (c116s) and arg 42 replaced by lys (r42k), in complex with fad and 4-hydroxybenzoic acid
    59% identity, 99% coverage of query (464 bits)

PHHY_PSEAE / P20586 p-hydroxybenzoate hydroxylase; PHBH; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 7 papers)
1d7lA / P20586 Structure-function correlations of the reaction of reduced nicotinamide analogs with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins (see paper)
    59% identity, 99% coverage of query (463 bits)

1iusA P-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate at ph 5.0
    59% identity, 99% coverage of query (463 bits)

1dodA The mobil flavin of 4-oh benzoate hydroxylase: motion of a prosthetic group regulates catalysis
    59% identity, 99% coverage of query (463 bits)

1k0lA Pseudomonas aeruginosa phbh r220q free of p-ohb
    59% identity, 99% coverage of query (461 bits)

1k0jA Pseudomonas aeruginosa phbh r220q in complex with NADPH and free of p- ohb
    59% identity, 99% coverage of query (461 bits)

6dllB / Q88H28 2.2 angstrom resolution crystal structure of p-hydroxybenzoate hydroxylase from pseudomonas putida in complex with fad. (see paper)
    58% identity, 99% coverage of query (457 bits)

1ykjB A45g p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound
    59% identity, 99% coverage of query (454 bits)

pobA / Q9R9T1 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas putida (see paper)
Q9R9T1 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas putida (see paper)
    57% identity, 99% coverage of query (451 bits)

Pf6N2E2_2914 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas fluorescens FW300-N2E2
    56% identity, 99% coverage of query (447 bits)

RR42_RS21940 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Cupriavidus basilensis FW507-4G11
    59% identity, 99% coverage of query (438 bits)

pobA / F2JUE7 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) (see paper)
    54% identity, 99% coverage of query (437 bits)

7on9A / C4TP09 Crystal structure of para-hydroxybenzoate-3-hydroxylase prai (see paper)
    49% identity, 100% coverage of query (375 bits)

PRAI_PAESP / C4TP09 4-hydroxybenzoate 3-monooxygenase (NAD(P)H); 4-hydroxybenzoate 3-hydroxylase; 4HB 3-hydroxylase; EC 1.14.13.33 from Paenibacillus sp. (see paper)
praI / BAH79107.1 4-hydroxybenzoate 3-hydroxylase from Paenibacillus sp. JJ-1b (see paper)
    49% identity, 100% coverage of query (375 bits)

8jqoA Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
    43% identity, 100% coverage of query (333 bits)

8jqoD Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
    42% identity, 76% coverage of query (234 bits)

Build an alignment

Build an alignment for Ga0059261_0531 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

pcpB / P42535 pentachlorophenol hydroxylase monomer (EC 1.14.13.50) from Sphingobium chlorophenolicum (see 8 papers)
PCPB_SPHCR / P42535 Pentachlorophenol 4-monooxygenase; Pentachlorophenol hydroxylase; EC 1.14.13.50 from Sphingobium chlorophenolicum (see 3 papers)
P42535 pentachlorophenol monooxygenase (EC 1.14.13.50) from Sphingobium chlorophenolicum (see 2 papers)
    24% identity, 81% coverage of query (74.7 bits)

stiL / CAD19095.1 cytochrome P450 dependent monooxygenase from Stigmatella aurantiaca (see paper)
    25% identity, 84% coverage of query (69.7 bits)

tsdB / Q0SFL5 resorcinol 4-hydroxylase (NADH) (EC 1.14.13.220) from Rhodococcus jostii (strain RHA1) (see 2 papers)
TSDB_RHOJR / Q0SFL5 Probable NADH-specific resorcinol 4-hydroxylase; EC 1.14.13.220 from Rhodococcus jostii (strain RHA1) (see paper)
    26% identity, 84% coverage of query (64.3 bits)

jadH / Q5U913 JadH monooxygenase/dehydratase from Streptomyces venezuelae (see 3 papers)
    26% identity, 82% coverage of query (62.8 bits)

DPASE_APISA / P9WEX4 FAD-dependent monooxygenase dpasE; Diterpenoid pyrone biosynthesis cluster protein E; EC 1.-.-.- from Apiospora sacchari (Arthrinium sacchari) (see paper)
    24% identity, 87% coverage of query (62.4 bits)

2qa2A / D0VWY3 Crystal structure of cabe, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 a resolution (see paper)
    26% identity, 80% coverage of query (61.2 bits)

rif19 / Q9AE02 rifamycin ring hydroxylase from Amycolatopsis mediterranei (see 4 papers)
    26% identity, 80% coverage of query (61.2 bits)

4k2xB / L8EUQ6 Oxys anhydrotetracycline hydroxylase from streptomyces rimosus (see paper)
    24% identity, 87% coverage of query (60.8 bits)

penE / A0A1B2CTA8 (2E)-4,8-dimethyl-4-hydroxynona-2,7-dienyl-quinolinone B epoxidase from Penicillium thymicola (see 2 papers)
PENE_PENTH / A0A1B2CTA8 FAD-dependent monooxygenase penE; Penigequinolones biosynthesis cluster protein E; EC 1.-.-.- from Penicillium thymicola (see 2 papers)
    25% identity, 87% coverage of query (60.1 bits)

oxyS / L8EUQ6 anhydrotetracycline monooxygenase monomer (EC 1.14.13.234; EC 1.14.13.38) from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see 6 papers)
OXYS_STRR1 / L8EUQ6 12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenase; EC 1.14.13.234; EC 1.14.13.38 from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see paper)
L8EUQ6 5a,11a-dehydrotetracycline 5-monooxygenase (EC 1.14.13.234) from Streptomyces rimosus subsp. rimosus (see paper)
    24% identity, 87% coverage of query (59.7 bits)

OTCC_STRRM / Q58PK7 Anhydrotetracycline monooxygenase; EC 1.14.13.38 from Streptomyces rimosus (see paper)
Q58PK7 anhydrotetracycline 6-monooxygenase (EC 1.14.13.38) from Streptomyces rimosus (see paper)
    24% identity, 87% coverage of query (58.5 bits)

6j0zC / Q6VMI4 Crystal structure of alpk (see paper)
    25% identity, 80% coverage of query (57.0 bits)

6brdA / F2R776 Crystal structure of rifampin monooxygenase from streptomyces venezuelae, complexed with rifampin and fad (see paper)
    27% identity, 80% coverage of query (56.6 bits)

ROX_STRVP / F2R776 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
    27% identity, 80% coverage of query (56.2 bits)

7vwpB / A0A136PK59 Structure of the flavin-dependent monooxygenase flso1 from the biosynthesis of fluostatinsin
    25% identity, 83% coverage of query (55.5 bits)

DPMPE_MACPH / K2QVI4 FAD-dependent monooxygenase dpmpE; Diterpenoid pyrone biosynthesis cluster protein E; EC 1.-.-.- from Macrophomina phaseolina (strain MS6) (Charcoal rot fungus) (see paper)
    25% identity, 91% coverage of query (55.5 bits)

6ui5A / Q1MX79 Tmn9 in complex with cofactor fad
    25% identity, 80% coverage of query (54.3 bits)

5kowA / Q5YTV5 Structure of rifampicin monooxygenase (see paper)
    26% identity, 80% coverage of query (53.5 bits)

6c7sA Structure of rifampicin monooxygenase with product bound
    26% identity, 80% coverage of query (53.5 bits)

5koxA Structure of rifampicin monooxygenase complexed with rifampicin
    26% identity, 80% coverage of query (53.5 bits)

ROX_NOCFA / Q5YTV5 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Nocardia farcinica (strain IFM 10152) (see 3 papers)
Q5YTV5 rifampicin monooxygenase (EC 1.14.13.211) from Nocardia farcinica (see paper)
    26% identity, 80% coverage of query (53.5 bits)

8fhjC Crystal structure of a fad monooxygenease from methylocystis sp. Strain sb2 (see paper)
    26% identity, 89% coverage of query (52.8 bits)

7oujAAA / Q8KY42 7oujAAA (see paper)
    24% identity, 83% coverage of query (52.4 bits)

nat2 / F8QPH2 ansamycin ring hydroxylase from Streptomyces sp. CS (see 5 papers)
    25% identity, 79% coverage of query (52.4 bits)

mtmOII / Q194R1 MtmOII from Streptomyces argillaceus (see 3 papers)
    21% identity, 82% coverage of query (50.8 bits)

7yj0D Structural basis of oxepinone formation by a flavin-monooxygenase vibo
    24% identity, 82% coverage of query (50.8 bits)

jadF / Q5U915 UWM6 dehydratase from Streptomyces venezuelae (see 4 papers)
    24% identity, 82% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory