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Searching for up to 100 curated homologs for Ga0059261_1963 FitnessBrowser__Korea:Ga0059261_1963 (531 a.a.)

Found high-coverage hits (≥70%) to 47 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9I0K4 isocitrate lyase (EC 4.1.3.1) from Pseudomonas aeruginosa (see 2 papers)
    80% identity, 99% coverage of query (879 bits)

A8C781 isocitrate lyase (EC 4.1.3.1) from Azotobacter vinelandii (see paper)
    79% identity, 99% coverage of query (876 bits)

Psest_2014 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas stutzeri RCH2
    79% identity, 99% coverage of query (875 bits)

Q93R40 isocitrate lyase (EC 4.1.3.1) from Colwellia maris (see paper)
    73% identity, 100% coverage of query (801 bits)

6g1oA / Q9I0K4 Structure of pseudomonas aeruginosa isocitrate lyase, icl (see paper)
    79% identity, 91% coverage of query (797 bits)

A8C5K8 isocitrate lyase (EC 4.1.3.1) from Colwellia psychrerythraea (see paper)
    72% identity, 100% coverage of query (794 bits)

ACEA_HYPME / O50078 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Hyphomicrobium methylovorum (see paper)
    58% identity, 98% coverage of query (612 bits)

Build an alignment

Build an alignment for Ga0059261_1963 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
    28% identity, 94% coverage of query (137 bits)

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
    28% identity, 92% coverage of query (137 bits)

Icl / b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655 (see paper)
aceA / P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12) (see 25 papers)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12) (see 7 papers)
    28% identity, 92% coverage of query (135 bits)

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
    27% identity, 94% coverage of query (134 bits)

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
    29% identity, 76% coverage of query (133 bits)

1igwC / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    27% identity, 92% coverage of query (133 bits)

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
    27% identity, 91% coverage of query (132 bits)

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
    27% identity, 92% coverage of query (130 bits)

ACEA_KLULA / Q8NJ72 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    27% identity, 83% coverage of query (129 bits)

7cmyC / Q81GQ9 Isocitrate lyase from bacillus cereus atcc 14579 in complex with magnessium ion, glyoxylate, and succinate
    27% identity, 95% coverage of query (129 bits)

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus (see paper)
    27% identity, 92% coverage of query (129 bits)

5e9gD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    28% identity, 80% coverage of query (127 bits)

Ac3H11_2831 Isocitrate lyase (EC 4.1.3.1) from Acidovorax sp. GW101-3H11
    27% identity, 77% coverage of query (126 bits)

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus (see paper)
    28% identity, 77% coverage of query (126 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    26% identity, 81% coverage of query (125 bits)

icl / CAA82555.1 isocitrate lyase from Rhodococcus fascians (see paper)
    27% identity, 76% coverage of query (124 bits)

6lrtA / A9WDE7 Crystal structure of isocitrate lyase (caur_3889) from chloroflexus aurantiacus in complex with isocitrate and manganese ion
    27% identity, 84% coverage of query (122 bits)

ACEA_PYRO7 / P0CT06 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae) (see paper)
P0CT06 isocitrate lyase (EC 4.1.3.1) from Pyricularia oryzae (see paper)
ICL1 isocitrate lyase from Magnaporthe grisea 70-15 (see paper)
    27% identity, 83% coverage of query (122 bits)

A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii (see paper)
    25% identity, 91% coverage of query (121 bits)

5e9gB / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    27% identity, 80% coverage of query (120 bits)

5e9gC Structural insights of isocitrate lyases from magnaporthe oryzae
    28% identity, 78% coverage of query (120 bits)

7rbxC / Q2YQA0 Crystal structure of isocitrate lyase and phosphorylmutase:isocitrate lyase from brucella melitensis biovar abortus 2308 bound to itaconic acid (see paper)
    26% identity, 92% coverage of query (119 bits)

7ebeA / Q9P8Q7 Crystal structure of isocitrate lyase-1 from candida albicans (see paper)
    26% identity, 81% coverage of query (118 bits)

ICL1 Isocitrate lyase from Candida albicans (see 2 papers)
    26% identity, 81% coverage of query (118 bits)

Q9P8Q7 isocitrate lyase (EC 4.1.3.1) from Candida albicans (see 2 papers)
    26% identity, 81% coverage of query (118 bits)

ACEA_ORYSJ / Q6Z6M4 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
    26% identity, 92% coverage of query (117 bits)

6c4aA / P9WKK7 Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis with pyruvate (see paper)
    26% identity, 77% coverage of query (115 bits)

icl / P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see 3 papers)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis (see 4 papers)
    26% identity, 77% coverage of query (115 bits)

6xppA Crystal structure of itaconate modified mycobaterium tuberculosis isocitrate lyase
    26% identity, 77% coverage of query (115 bits)

7rb1A Isocitrate lyase-1 from mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-d-isocitric acid
    26% identity, 77% coverage of query (115 bits)

6wsiA Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium tuberculosis
    26% identity, 77% coverage of query (115 bits)

6vb9A Covalent adduct of cis-2,3-epoxysuccinic acid with isocitrate lyase-1 from mycobacterium tuberculosis
    26% identity, 77% coverage of query (115 bits)

5dqlA Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis
    26% identity, 77% coverage of query (115 bits)

ACEA_NEUCR / P28299 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 2 papers)
    26% identity, 83% coverage of query (112 bits)

1f8iA Crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
    26% identity, 77% coverage of query (112 bits)

5e9fD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    29% identity, 78% coverage of query (109 bits)

1igwA / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    26% identity, 92% coverage of query (102 bits)

5e9fB / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    26% identity, 78% coverage of query (102 bits)

5e9fA Structural insights of isocitrate lyases from magnaporthe oryzae
    26% identity, 78% coverage of query (99.8 bits)

ACEA_EMENI / P28298 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
acuD / PDB|1DQU_A isocitrate lyase; EC 4.1.3.1 from Emericella nidulans (see 4 papers)
    25% identity, 83% coverage of query (91.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory