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Searching for up to 100 curated homologs for Ga0059261_2711 FitnessBrowser__Korea:Ga0059261_2711 (430 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

Removed hits that are identical to the query, leaving 24

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
    44% identity, 97% coverage of query (315 bits)

DHOM_NEIG1 / Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
    46% identity, 89% coverage of query (305 bits)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
    40% identity, 100% coverage of query (273 bits)

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    37% identity, 96% coverage of query (270 bits)

DHOM_CORGL / P08499 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
P08499 homoserine dehydrogenase (EC 1.1.1.3) from Corynebacterium glutamicum (see 2 papers)
    42% identity, 95% coverage of query (268 bits)

6dzsA / K5BJC9 Mycobacterial homoserine dehydrogenase thra in complex with NADP
    43% identity, 95% coverage of query (266 bits)

DvMF_1412 homoserine dehydrogenase (EC 1.1.1.3) from Desulfovibrio vulgaris Miyazaki F
    39% identity, 99% coverage of query (257 bits)

DHOM_BACSU / P19582 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Bacillus subtilis (strain 168) (see paper)
P19582 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus subtilis (see paper)
    37% identity, 95% coverage of query (252 bits)

DHOM_LACLC / P52985 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (see paper)
    35% identity, 95% coverage of query (244 bits)

P46806 homoserine dehydrogenase (EC 1.1.1.3) from Mycobacterium leprae (see paper)
    42% identity, 94% coverage of query (243 bits)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus (see 2 papers)
    40% identity, 74% coverage of query (232 bits)

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    38% identity, 78% coverage of query (220 bits)

4pg7A / A0A0M3KKV6 Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
    39% identity, 74% coverage of query (213 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    37% identity, 74% coverage of query (191 bits)

Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus (see paper)
6a0tB / Q5SL04 Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
    38% identity, 77% coverage of query (138 bits)

6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH
    38% identity, 77% coverage of query (137 bits)

2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
    38% identity, 77% coverage of query (137 bits)

Build an alignment

Build an alignment for Ga0059261_2711 and 17 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii (see paper)
4xb1A / O58802 Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
    29% identity, 73% coverage of query (114 bits)

4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH
    29% identity, 73% coverage of query (114 bits)

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3) from Candida albicans (see 2 papers)
    26% identity, 75% coverage of query (95.5 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 73% coverage of query (77.0 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    24% identity, 73% coverage of query (74.7 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    24% identity, 75% coverage of query (70.1 bits)

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    25% identity, 73% coverage of query (57.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory