Searching for up to 100 curated homologs for Ga0059261_3272 FitnessBrowser__Korea:Ga0059261_3272 (221 a.a.)
Found high-coverage hits (≥70%) to 57 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
aqpS / Q92R43 aquaglyceroporin from Rhizobium meliloti (strain 1021) (see 2 papers)
AQPS_RHIME / Q92R43 Aquaglyceroporin AqpS from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
TC 1.A.8.12.10 / Q92R43 Arsenite export pore, AqpS (see paper)
54% identity, 99% coverage of query (212 bits)
PIP28_ORYSJ / Q7Y1E6 Probable aquaporin PIP2-8; OsPIP2;8; Plasma membrane intrinsic protein 2-8 from Oryza sativa subsp. japonica (Rice) (see paper)
31% identity, 97% coverage of query (77.4 bits)
PIP28_ARATH / Q9ZVX8 Probable aquaporin PIP2-8; Plasma membrane intrinsic protein 2-8; AtPIP2;8; Plasma membrane intrinsic protein 3b; PIP3b from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 1.A.8.11.6 / Q9ZVX8 Aquaporin PIP2-8 (Plasma membrane intrinsic protein 2-8) (AtPIP2;8) (Plasma membrane intrinsic protein 3b) (PIP3b) from Arabidopsis thaliana (see 4 papers)
30% identity, 97% coverage of query (71.2 bits)
PIP27_ARATH / P93004 Aquaporin PIP2-7; Plasma membrane intrinsic protein 2-7; AtPIP2;7; Plasma membrane intrinsic protein 3; At-PIP3; Salt stress-induced major intrinsic protein from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
33% identity, 70% coverage of query (70.5 bits)
AQP1_HUMAN / P29972 Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule from Homo sapiens (Human) (see 5 papers)
TC 1.A.8.8.1 / P29972 Aquaporin 1 (CO2-, O2- and nitrous oxide-permeable and water-selective) (Zwiazek et al. 2017). Aquaporin-1 tunes pain perception by interacting with Na(v)1.8 Na+ channels in dorsal root ganglion neurons (Zhang and Verkman, 2010). It is upregulated in skeletal muscle in muscular dystrophy (Au et al. 2008). AQP1 has been reported to first insert as a four-helical intermediate, where helices 2 and 4 are not inserted into the membrane. In a second step this intermediate is folded into a six-helical topology. During this process, the orientation of the third helix is inverted, and it can shift out the membrane core from Homo sapiens (Human) (see 19 papers)
30% identity, 95% coverage of query (70.1 bits)
8ct2D / P29972 Local refinement of aqp1 tetramer (c1; refinement mask included d1 of protein 4.2 and ankyrin-1 ar1-5) in class 2 of erythrocyte ankyrin-1 complex (see paper)
30% identity, 95% coverage of query (69.7 bits)
PIP23_ARATH / P30302 Aquaporin PIP2-3; Plasma membrane intrinsic protein 2-3; AtPIP2;3; Plasma membrane intrinsic protein 2c; PIP2c; RD28-PIP; TMP2C; Water stress-induced tonoplast intrinsic protein; WSI-TIP from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
33% identity, 70% coverage of query (67.8 bits)
PIP22_ARATH / P43287 Aquaporin PIP2-2; Plasma membrane intrinsic protein 2-2; AtPIP2;2; Plasma membrane intrinsic protein 2b; PIP2b; TMP2b from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
33% identity, 70% coverage of query (66.6 bits)
PIP21_ARATH / P43286 Aquaporin PIP2-1; Plasma membrane intrinsic protein 2-1; AtPIP2;1; Plasma membrane intrinsic protein 2a; PIP2a from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.11.4 / P43286 Plasma membrane intrinsic protein 2a (forms active heterotetramers with PIP1;1 (TC# 1.A.8.11.3); down regulated under drought stress (Najafabadi et al., 2008). Transports H2O2 (Dynowski et al., 2008). The Mesembryanthemum crystallinum PIP2;1 orthologue is an aquaporin impermeable to urea and glycerol. It is positively regulated by PKA- and PKC- mediated phosphorylation (Amezcua-Romero et al., 2010). PIP1;1 and PIP2;2 (Q9ATM8) co-expression modulates the membrane water permeability in the halophyte Beta vulgaris storage root through a pH regulatory response, enhancing membrane versatility to adjust its water transfer capacity from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
33% identity, 70% coverage of query (65.1 bits)
Build an alignment for Ga0059261_3272 and 9 homologs with ≥ 30% identity
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PIP27_MUSAC / A0A6M3QG69 Aquaporin PIP2-7; PIP2-6-like protein PIP2-7; Plasma membrane intrinsic protein 2-7; MaPIP2-7; MaPIP2;7 from Musa acuminata (Banana) (Musa cavendishii) (see 2 papers)
27% identity, 97% coverage of query (62.8 bits)
PIP23_ORYSJ / Q7XUA6 Probable aquaporin PIP2-3; OsPIP2;3; Plasma membrane intrinsic protein 2-3 from Oryza sativa subsp. japonica (Rice) (see paper)
28% identity, 97% coverage of query (62.4 bits)
pip2.4 / CAH60723.1 putative plasma membrane intrinsic protein from Populus tremula x Populus tremuloides (see paper)
29% identity, 97% coverage of query (61.2 bits)
NIP2-1 / Q6Z2T3 aquaporin NIP2-1 from Oryza sativa subsp. japonica (see 7 papers)
NIP21_ORYSJ / Q6Z2T3 Aquaporin NIP2-1; Low silicon protein 1; NOD26-like intrinsic protein 2-1; OsNIP2;1; Silicon influx transporter LSI1 from Oryza sativa subsp. japonica (Rice) (see 6 papers)
TC 1.A.8.12.2 / Q6Z2T3 The silicon (silicic acid) (undissociated form) transporter, Lsi1 (Ma et al., 2007a, b; Mitani et al., 2008). The barley orthologue Lsi1 (also called NIP2-1) is also a silicon (silicic acid) uptake channel (Chiba et al., 2009). Rice Lsi1 also transports arsenite and pentavalent mono and dimethyl arsenite (Li et al., 2009). In addition to silicon (Si), selenite (Se) uptake is mediated by Lsi1, also called NIP2;1 from Oryza sativa (Rice) (see 6 papers)
NIP2-1 / GI|90855460 aquaporin NIP2-1 from Oryza sativa (japonica cultivar-group) (see paper)
30% identity, 99% coverage of query (61.2 bits)
PIP26_ORYSJ / Q7XLR1 Probable aquaporin PIP2-6; OsPIP2;6; Plasma membrane intrinsic protein 2-6 from Oryza sativa subsp. japonica (Rice) (see paper)
28% identity, 97% coverage of query (60.8 bits)
PregAQP1 / BAM26200.1 aquaporin from Phormia regina (see paper)
32% identity, 97% coverage of query (60.5 bits)
TC 1.A.8.8.16 / Q32ZE5 Aquaporin-1 or Aquaporin1, Aqp1, of 258 aas and 6 TMSs. Three Aqp1 isoforms are differentially from Sparus aurata
27% identity, 97% coverage of query (60.5 bits)
PIP24_MAIZE / Q9ATM6 Aquaporin PIP2-4; Plasma membrane intrinsic protein 2-4; ZmPIP2-4; ZmPIP2;4 from Zea mays (Maize) (see 2 papers)
32% identity, 70% coverage of query (60.5 bits)
TC 1.A.8.8.18 / B6ZHB9 Aqp-x2 water channel in the luminal epithelium of urinary bladder cells and lungs from Xenopus laevis
28% identity, 97% coverage of query (60.1 bits)
AQP2_RAT / P34080 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Rattus norvegicus (Rat) (see 3 papers)
30% identity, 97% coverage of query (59.7 bits)
pip2.5 / CAH60724.1 putative plasma membrane intrinsic protein from Populus tremula x Populus tremuloides (see paper)
31% identity, 70% coverage of query (59.3 bits)
PIP2-1 / AAV69744.1 aquaporin from Vitis vinifera (see paper)
30% identity, 70% coverage of query (58.5 bits)
AQP2_MOUSE / P56402 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Mus musculus (Mouse) (see 5 papers)
30% identity, 97% coverage of query (58.5 bits)
PIP27_ORYSJ / Q651D5 Probable aquaporin PIP2-7; OsPIP2;7; Plasma membrane intrinsic protein 2-7 from Oryza sativa subsp. japonica (Rice) (see paper)
30% identity, 98% coverage of query (58.5 bits)
PIP22_ORYSJ / Q6K215 Probable aquaporin PIP2-2; OsPIP2;2; Plasma membrane intrinsic protein 2-2 from Oryza sativa subsp. japonica (Rice) (see paper)
32% identity, 70% coverage of query (58.5 bits)
PIP25_MAIZE / Q9XF58 Aquaporin PIP2-5; Plasma membrane intrinsic protein 2-5; ZmPIP2-5; ZmPIP2;5; ZmPIP2a from Zea mays (Maize) (see 4 papers)
TC 1.A.8.11.7 / Q9XF58 Aquaporin PIP2;5 (PIP2-5) of 285 aas from Zea mays
31% identity, 70% coverage of query (58.2 bits)
PIP25_ORYSJ / Q8GRI8 Aquaporin PIP2-5; OsPIP2;5; Plasma membrane intrinsic protein 2-5 from Oryza sativa subsp. japonica (Rice) (see paper)
31% identity, 70% coverage of query (58.2 bits)
TC 1.A.8.8.15 / B5L019 Mercury-sensitive whitefly aquaporin-1 of the specialized filter chamber of the alimentary tract from Bemisia tabaci
25% identity, 99% coverage of query (57.8 bits)
AQP1_CANLF / Q9N2J4 Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule from Canis lupus familiaris (Dog) (Canis familiaris) (see paper)
27% identity, 95% coverage of query (57.4 bits)
NIP22_ORYSJ / Q67WJ8 Aquaporin NIP2-2; Low silicon protein 6; NOD26-like intrinsic protein 2-2; OsNIP2;2 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
TC 1.A.8.12.5 / Q67WJ8 The silicon (silicic acid) transporter, Nip2-2 (Nip2;2) (Mitani et al., 2008). Also transports arsenite from Oryza sativa subsp. japonica (Rice) (see 5 papers)
29% identity, 96% coverage of query (57.0 bits)
AQP1_MOUSE / Q02013 Aquaporin-1; AQP-1; Aquaporin-CHIP; Delayed early response protein 2; DER2; Water channel protein for red blood cells and kidney proximal tubule from Mus musculus (Mouse) (see 3 papers)
26% identity, 95% coverage of query (57.0 bits)
PIP21_MAIZE / Q84RL7 Aquaporin PIP2-1; Plasma membrane intrinsic protein 2-1; ZmPIP2-1; ZmPIP2;1 from Zea mays (Maize) (see 2 papers)
28% identity, 97% coverage of query (57.0 bits)
TC 1.A.8.13.1 / O28846 MIP family homologue from Archaeoglobus fulgidus (see paper)
33% identity, 98% coverage of query (57.0 bits)
NIP1 / CAD67694.1 Nod26-like protein from Cucurbita pepo (see paper)
26% identity, 99% coverage of query (56.6 bits)
PIP21_ORYSJ / Q8H5N9 Probable aquaporin PIP2-1; OsPIP2;1; Plasma membrane intrinsic protein 2-1; Plasma membrane intrinsic protein 2a; PIP2a from Oryza sativa subsp. japonica (Rice) (see 2 papers)
28% identity, 97% coverage of query (56.2 bits)
TIP22_ORYSJ / Q5Z6F0 Probable aquaporin TIP2-2; Tonoplast intrinsic protein 2-2; OsTIP2;2 from Oryza sativa subsp. japonica (Rice) (see paper)
32% identity, 71% coverage of query (56.2 bits)
TIP12_ARATH / Q41963 Aquaporin TIP1-2; Gamma-tonoplast intrinsic protein 2; Gamma-TIP2; Salt stress-induced tonoplast intrinsic protein; Tonoplast intrinsic protein 1-2; AtTIP1;2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 1.A.8.10.9 / Q41963 Aquaporin TIP1-2 (Gamma-tonoplast intrinsic protein 2) (Gamma-TIP2) (Salt stress-induced tonoplast intrinsic protein) (Tonoplast intrinsic protein 1-2) (AtTIP1;2) from Arabidopsis thaliana (see 8 papers)
29% identity, 98% coverage of query (54.3 bits)
AQP5_MOUSE / Q9WTY4 Aquaporin-5; AQP-5 from Mus musculus (Mouse) (see 7 papers)
30% identity, 97% coverage of query (54.3 bits)
AQP1_SHEEP / P56401 Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule from Ovis aries (Sheep) (see paper)
27% identity, 95% coverage of query (54.3 bits)
GLPF6_LACPL / F9UUD2 Glycerol uptake facilitator protein-like 6 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
29% identity, 83% coverage of query (54.3 bits)
PIP25_ARATH / Q9SV31 Probable aquaporin PIP2-5; Plasma membrane intrinsic protein 2-5; AtPIP2;5; Plasma membrane intrinsic protein 2d; PIP2d from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 97% coverage of query (54.3 bits)
pip2.3 / CAH60722.1 putative plasma membrane intrinsic protein from Populus tremula x Populus tremuloides (see paper)
30% identity, 70% coverage of query (53.5 bits)
AQP2_HUMAN / P41181 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Homo sapiens (Human) (see 23 papers)
TC 1.A.8.8.8 / P41181 Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct from Homo sapiens (Human) (see 22 papers)
28% identity, 97% coverage of query (53.1 bits)
BIB_DROME / P23645 Neurogenic protein big brain from Drosophila melanogaster (Fruit fly) (see 6 papers)
TC 1.A.8.8.3 / P23645 The BIB aquaporin of D. melanogaster (transports ions by a channel mechanism involving E71 in TMS1) (Yool, 2007) from Drosophila melanogaster (Fruit fly) (see 9 papers)
bib / RF|NP_476837.1 neurogenic protein big brain from Drosophila melanogaster (see paper)
30% identity, 80% coverage of query (52.8 bits)
4nefA / P41181 X-ray structure of human aquaporin 2 (see paper)
28% identity, 97% coverage of query (52.8 bits)
VIP1 / BAA12711.1 VM23 from Raphanus sativus (see paper)
30% identity, 98% coverage of query (51.6 bits)
PIP14_ARATH / Q39196 Probable aquaporin PIP1-4; Plasma membrane intrinsic protein 1-4; AtPIP1;4; Transmembrane protein C; TMP-C from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 97% coverage of query (51.6 bits)
AQP4_BOVIN / O77750 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Bos taurus (Bovine) (see paper)
29% identity, 78% coverage of query (51.2 bits)
PIP13_ARATH / Q08733 Aquaporin PIP1-3; AtPIP1;3; Plasma membrane intrinsic protein 1c; PIP1c; Transmembrane protein B; TMP-B from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
29% identity, 70% coverage of query (51.2 bits)
AQP4_MOUSE / P55088 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Mus musculus (Mouse) (see 11 papers)
29% identity, 77% coverage of query (51.2 bits)
AQP4_HUMAN / P55087 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Homo sapiens (Human) (see 5 papers)
TC 1.A.8.8.5 / P55087 Aquaporin-4 (AQP4) is the major water channel in the central nervous system and plays an important role in the brain's water balance, including edema formation and clearance. There are 6 splice variants; the shorter ones assemble into functional, tetrameric square arrays; the longer is palmitoylated on N-terminal cysteyl residues) (Suzuki et al., 2008). The longest, Aqp4e, has a novel N-terminal domain and forms a water channel in the plasma membrane although various shorter variants don't (Moe et al., 2008). AQP4, like AQP0 (1.A.8.8.2), forms water channels but also forms adhesive junctions (Engel et al., 2008) (causes cytotoxic brain swelling in mice (Yang et al., 2008)) Mice lacking Aqp4 have impaired olfactions (Lu et al., 2008). Aqp4 is down regulated in skeletal muscle in muscular dystrophy (Au et al. 2008). The crystal structure is known to 2.8 Å resolution (Tani et al., 2009). The structure reveals 8 water molecules in each of the four channels, supporting a hydrogen-bond isolation mechanism and explains its fast and selective water conduction and proton exclusion (Tani et al., 2009; Cui and Bastien, 2011). It is an important antigen in Neuromyelitis optica (NMO) patients from Homo sapiens (Human) (see 4 papers)
29% identity, 77% coverage of query (51.2 bits)
AQP4_DIPME / Q923J4 Aquaporin-4; AQP-4 from Dipodomys merriami (Merriam's kangaroo rat) (see paper)
29% identity, 77% coverage of query (51.2 bits)
AQP4_RAT / P47863 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Rattus norvegicus (Rat) (see 7 papers)
29% identity, 77% coverage of query (50.8 bits)
PIP26_ARATH / Q9ZV07 Probable aquaporin PIP2-6; Plasma membrane intrinsic protein 2-6; AtPIP2;6; Plasma membrane intrinsic protein 2e; PIP2e from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 1.A.8.11.5 / Q9ZV07 Probable aquaporin PIP2-6 (Plasma membrane intrinsic protein 2-6) (AtPIP2;6) (Plasma membrane intrinsic protein 2e) (PIP2e) from Arabidopsis thaliana (see 5 papers)
29% identity, 70% coverage of query (50.4 bits)
P09011 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Rattus norvegicus (Rat)
31% identity, 79% coverage of query (48.1 bits)
PIP11_ARATH / P61837 Aquaporin PIP1-1; AtPIP1;1; Plasma membrane aquaporin-1; Plasma membrane intrinsic protein 1a; PIP1a from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.11.3 / P61837 Plasma membrane aquaporin 1, PIP1, of 286 aas and 6 TMSs from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
PIP1-1 / RF|NP_191702.1 aquaporin PIP1-1 from Arabidopsis thaliana (see paper)
27% identity, 96% coverage of query (47.4 bits)
2evuA / Q9C4Z5 Crystal structure of aquaporin aqpm at 2.3a resolution (see paper)
31% identity, 97% coverage of query (46.2 bits)
TIP11_ARATH / P25818 Aquaporin TIP1-1; Aquaporin TIP; Gamma-tonoplast intrinsic protein; Gamma-TIP; Tonoplast intrinsic protein 1-1; AtTIP1;1; Tonoplast intrinsic protein, root-specific RB7 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.10.3 / P25818 Tonoplast intrinsic protein 1.1 (permeable to water and H2O2) from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
TIP1-1 / RF|NP_181221.1 aquaporin TIP1-1 from Arabidopsis thaliana
28% identity, 98% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory