Searching for up to 100 curated homologs for Ga0059261_3276 Ga0059261_3276 ABC-type multidrug transport system, ATPase and permease components (595 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
hcuC / BAC81752.1 hydrophobic compound transport factor from Pseudomonas aeruginosa (see paper)
48% identity, 97% coverage of query (484 bits)
MITOS_RAT / Q5RKI8 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Rattus norvegicus (Rat) (see paper)
37% identity, 100% coverage of query (375 bits)
MITOS_MOUSE / Q9CXJ4 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Mus musculus (Mouse) (see paper)
37% identity, 100% coverage of query (373 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
39% identity, 86% coverage of query (358 bits)
ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
39% identity, 86% coverage of query (357 bits)
4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
39% identity, 84% coverage of query (357 bits)
MITOS_HUMAN / Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 5 papers)
Q9NUT2 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
TC 3.A.1.201.22 / Q9NUT2 Mitochondrial ATP-binding cassette 1, ABCB8 from Homo sapiens
39% identity, 87% coverage of query (355 bits)
5ochE / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
39% identity, 87% coverage of query (354 bits)
ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
36% identity, 87% coverage of query (345 bits)
7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
38% identity, 84% coverage of query (345 bits)
7vfiA Cryo-em structure of the mouse tapl (9mer-peptide bound)
37% identity, 81% coverage of query (343 bits)
7v5cA / Q9JJ59 Cryo-em structure of the mouse abcb9 (adp.Bef3-bound) (see paper)
37% identity, 81% coverage of query (342 bits)
ABCB9_MOUSE / Q9JJ59 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; mABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Mus musculus (Mouse) (see paper)
37% identity, 81% coverage of query (341 bits)
ABCB9_RAT / Q9QYJ4 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; TAP-like protein; TAPL; EC 7.4.2.6 from Rattus norvegicus (Rat) (see 3 papers)
37% identity, 81% coverage of query (340 bits)
TC 3.A.1.201.12 / B2WTH9 California mussel ABCB/MDR multixenobiotic resistance efflux pump from Mytilus californianus (see paper)
38% identity, 82% coverage of query (338 bits)
4aywA Structure of the human mitochondrial abc transporter, abcb10 (plate form)
38% identity, 84% coverage of query (338 bits)
7ehlA Cryo-em structure of human abcb8 transporter in nucleotide binding state
38% identity, 85% coverage of query (337 bits)
TC 3.A.1.201.16 / I0DHH7 MDR efflux pump, ABCB4a from Strongylocentrotus purpuratus
37% identity, 83% coverage of query (333 bits)
AB25B_ORYSJ / Q9FNU2 ABC transporter B family member 25; ABC transporter ABCB.25; OsABCB25; Protein ALS1 homolog; Protein ALUMINUM SENSITIVE 1; OsALS1 from Oryza sativa subsp. japonica (Rice) (see paper)
35% identity, 94% coverage of query (332 bits)
MDL1_SCHPO / Q9Y7M7 ATP-dependent permease MDL1, mitochondrial; ABC transporter mdl1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
mdl1 mitochondrial peptide-transporting ATPase from Schizosaccharomyces pombe (see 2 papers)
35% identity, 92% coverage of query (332 bits)
5ochC / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
38% identity, 87% coverage of query (330 bits)
TC 3.A.1.117.1 / P97046 The multidrug exporter, LmrA from Lactococcus lactis (see 2 papers)
36% identity, 83% coverage of query (325 bits)
7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
35% identity, 93% coverage of query (322 bits)
6a6mA / M1VAN7 Crystal structure of an outward-open nucleotide-bound state of the eukaryotic abc multidrug transporter cmabcb1 (see paper)
38% identity, 82% coverage of query (320 bits)
3wmgA Crystal structure of an inward-facing eukaryotic abc multidrug transporter g277v/a278v/a279v mutant in complex with an cyclic peptide inhibitor, acap
38% identity, 82% coverage of query (319 bits)
Q9HUG8 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Pseudomonas aeruginosa (see paper)
35% identity, 99% coverage of query (318 bits)
7fc9A Crystal structure of cmabcb1 in lipidic mesophase revealed by lcp-sfx
39% identity, 82% coverage of query (318 bits)
TC 3.A.1.201.21 / M1VAN7 Half sized ABCB1 drug (verapamil; rhodamine 6G) exporter of specificity similar to that of P-glycoprotein (3.A.1.201.1) from Cyanidioschyzon merolae strain 10D
38% identity, 82% coverage of query (317 bits)
TC 3.A.1.201.23 / Q8T9W4 The cyclic AMP efflux pump of 1432 aas, ABCB3 from Dictyostelium discoideum
35% identity, 83% coverage of query (315 bits)
TC 3.A.1.201.15 / Q3T7C8 MDR efflux pump, ABCB1a from Strongylocentrotus purpuratus
38% identity, 87% coverage of query (314 bits)
MSBA_VIBCH / Q9KQW9 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; EC 7.5.2.6 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
Q9KQW9 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Vibrio cholerae (see paper)
35% identity, 97% coverage of query (311 bits)
ABCB1 / RF|NP_000918.2 multidrug resistance protein 1 from Homo sapiens
35% identity, 90% coverage of query (311 bits)
ABCB1 / P08183 ATP-dependent translocase ABCB1 (EC 7.6.2.2) from Homo sapiens (see 39 papers)
MDR1_HUMAN / P08183 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Homo sapiens (Human) (see 8 papers)
P08183 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 10 papers)
TC 3.A.1.201.1 / P08183 Broad specificity multidrug resistance (MDR1; MDR-1; Pgp; P-gp; ABCB1; P-glycoprotein) efflux pump. It exports organic cations and amphiphilic compounds of unrelated chemical structure from Homo sapiens (Human) (see 19 papers)
35% identity, 90% coverage of query (311 bits)
6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
35% identity, 90% coverage of query (310 bits)
AB4B_ARATH / O80725 ABC transporter B family member 4; ABC transporter ABCB.4; AtABCB4; Multidrug resistance protein 4; P-glycoprotein 4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.7 / O80725 Auxin efflux pump Pgp4; AbcB4; MDR4; PGP4 (Lefèvre and Boutry 2018) of 1286 aas and 12 TMSs in a MCMC domain arrangement from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
MDR4 / RF|NP_182223.1 multidrug resistance protein 4; EC 3.6.3.44 from Arabidopsis thaliana (see paper)
35% identity, 83% coverage of query (310 bits)
YWJA_BACSU / P45861 Uncharacterized ABC transporter ATP-binding protein YwjA from Bacillus subtilis (strain 168) (see 2 papers)
36% identity, 85% coverage of query (308 bits)
7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
35% identity, 88% coverage of query (308 bits)
7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
35% identity, 88% coverage of query (308 bits)
7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
35% identity, 88% coverage of query (308 bits)
7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
35% identity, 88% coverage of query (308 bits)
7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
35% identity, 88% coverage of query (308 bits)
6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
35% identity, 93% coverage of query (308 bits)
BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
34% identity, 94% coverage of query (307 bits)
ABCB5_MOUSE / B5X0E4 ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
37% identity, 82% coverage of query (306 bits)
AB27B_ARATH / Q0WML0 ABC transporter B family member 27; ABC transporter ABCB.27; AtABCB27; Aluminum tolerance-related ATP-binding cassette transporter; Antigen peptide transporter-like 2; Transporter associated with antigen processing-like protein 2; AtTAP2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.8 / Q0WML0 The aluminum chelate (aluminum sensitivity (ALS1)) protein; expressed in root vacuoles half-type ABC transporter from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
TAP2 / RF|NP_198720.2 antigen peptide transporter-like 2 from Arabidopsis thaliana (see paper)
36% identity, 85% coverage of query (306 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
35% identity, 90% coverage of query (305 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
35% identity, 90% coverage of query (305 bits)
7ow8A / O06967 Cryoem structure of the abc transporter bmra e504a mutant in complex with atp-mg (see paper)
33% identity, 97% coverage of query (304 bits)
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
33% identity, 94% coverage of query (304 bits)
TC 3.A.1.201.25 / A5X7X7 MDR transporter, Crmdr1 of 1266 aas and 12 TMSs from Catharanthus roseus
35% identity, 89% coverage of query (304 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
36% identity, 88% coverage of query (304 bits)
2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
33% identity, 94% coverage of query (304 bits)
P63359 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
33% identity, 94% coverage of query (303 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
35% identity, 87% coverage of query (301 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
33% identity, 94% coverage of query (301 bits)
6s7pA Nucleotide bound abcb4
35% identity, 90% coverage of query (301 bits)
7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
33% identity, 94% coverage of query (301 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
35% identity, 88% coverage of query (301 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
33% identity, 94% coverage of query (301 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
35% identity, 88% coverage of query (301 bits)
MDR1A_MOUSE / P21447 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 1A; Multidrug resistance protein 3; P-glycoprotein 3; Phospholipid transporter ABCB1; EC 7.6.2.2; EC 7.6.2.1 from Mus musculus (Mouse) (see paper)
P21447 ABC-type xenobiotic transporter (EC 7.6.2.2) from Mus musculus (see paper)
35% identity, 87% coverage of query (300 bits)
AAA66477.1 SMDR2 from Schistosoma mansoni (see paper)
33% identity, 89% coverage of query (300 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
35% identity, 88% coverage of query (300 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
35% identity, 88% coverage of query (300 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
35% identity, 87% coverage of query (300 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
35% identity, 87% coverage of query (300 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
35% identity, 87% coverage of query (300 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
35% identity, 87% coverage of query (300 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
35% identity, 88% coverage of query (300 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
35% identity, 87% coverage of query (300 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
35% identity, 88% coverage of query (300 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
35% identity, 88% coverage of query (298 bits)
7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
33% identity, 94% coverage of query (298 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
33% identity, 94% coverage of query (298 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
33% identity, 94% coverage of query (298 bits)
7bcwA Structure of msba in salipro with adp vanadate
33% identity, 94% coverage of query (298 bits)
7mewA E. Coli msba in complex with g247
33% identity, 94% coverage of query (298 bits)
7bg4A Multidrug resistance transporter bmra mutant e504a bound with atp, mg, and rhodamine 6g solved by cryo-em
33% identity, 97% coverage of query (298 bits)
MDR1_CRIGR / P21448 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
35% identity, 87% coverage of query (297 bits)
MDR3_MOUSE / P21440 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; Multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3; EC 7.6.2.1 from Mus musculus (Mouse) (see 14 papers)
35% identity, 88% coverage of query (296 bits)
MDR2_ASPFU / Q4WPP6 ABC multidrug transporter mdr2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 4 papers)
34% identity, 92% coverage of query (296 bits)
MDR1_CRYNH / J9VF33 ABC multidrug transporter MDR1 from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) (see 2 papers)
TC 3.A.1.201.11 / O43140 Mdr1 azole resistance efflux pump from Cryptococcus neoformans (see paper)
34% identity, 86% coverage of query (295 bits)
TC 3.A.1.135.7 / E2YHZ7 ABC transporter, ATP-binding protein, component of Multidrug exporter, EfrAB from Enterococcus faecalis DAPTO 512
33% identity, 87% coverage of query (295 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
36% identity, 87% coverage of query (294 bits)
7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
34% identity, 91% coverage of query (293 bits)
At3g28860 / AAN28720.2 MDR-like p-glycoprotein from Arabidopsis thaliana (see paper)
36% identity, 90% coverage of query (293 bits)
AB19B_ARATH / Q9LJX0 ABC transporter B family member 19; ABC transporter ABCB.19; AtABCB19; Multidrug resistance protein 11; P-glycoprotein 19 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 3.A.1.201.6 / Q9LJX0 Auxin efflux pump Pgp19 (MDR11; ABCB19; ABCB21) (regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase (TC# 8.A.11.1.1) from Arabidopsis thaliana (Mouse-ear cress) (see 9 papers)
MDR11 / RF|NP_189528.1 multidrug resistance protein 11 from Arabidopsis thaliana (see paper)
36% identity, 90% coverage of query (293 bits)
ABCBB_CANLF / B8K1W2 Bile salt export pump; EC 7.6.2.- from Canis lupus familiaris (Dog) (Canis familiaris) (see paper)
33% identity, 92% coverage of query (293 bits)
7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
33% identity, 94% coverage of query (292 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
34% identity, 87% coverage of query (288 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
36% identity, 83% coverage of query (284 bits)
4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
31% identity, 95% coverage of query (281 bits)
6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
31% identity, 95% coverage of query (281 bits)
6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
33% identity, 83% coverage of query (280 bits)
ABCBB_RAT / O70127 Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; EC 7.6.2.- from Rattus norvegicus (Rat) (see 12 papers)
34% identity, 91% coverage of query (278 bits)
TAP2_RAT / P36372 Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; EC 7.4.2.14 from Rattus norvegicus (Rat) (see paper)
P36372 ABC-type antigen peptide transporter (subunit 1/2) (EC 7.4.2.14) from Rattus norvegicus (see 6 papers)
32% identity, 98% coverage of query (278 bits)
MDL1_YEAST / P33310 ATP-dependent permease MDL1, mitochondrial; ABC transporter MDL1; Multidrug resistance-like protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 3.A.1.212.1 / P33310 The mitochondrial peptide exporter, Mdl1p (exports peptides of 6-21 amino acyl residues from the mitochondrial matrix as well as degradation products of misassembled respiratory chain complexes) (Janas et al., 2003; van der Does et al., 2006; Gompf et al., 2007). A leaderless Mdl1p targets to the ER membrane instead of to the mitochondria from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
MDL1 / RF|NP_013289.1 ATP-dependent permease MDL1, mitochondrial; EC 3.6.3.43 from Saccharomyces cerevisiae (see paper)
34% identity, 85% coverage of query (278 bits)
TAP2_HUMAN / Q03519 Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter PSF2; PSF-2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Really interesting new gene 11 protein; RING11; EC 7.4.2.14 from Homo sapiens (Human) (see 28 papers)
Q03519 ABC-type antigen peptide transporter (subunit 1/2) (EC 7.4.2.14); bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 19 papers)
TC 3.A.1.209.1 / Q03519 TAP2 aka ABCB3 aka PSF2 aka RING11 aka Y1, component of MHC heterodimeric peptide exporter (TAP) (from cytoplasm to the endoplasmic reticulum) (TAP1=ABCB2; TAP2=ABCB3) (defects in TAP1 or TAP2 cause immunodeficiency) (TAP1/TAP2 is stabilized by tapasin isoforms 1, 2 and 3) (Raghuraman et al., 2002). TAP1 has 10 TMSs, 4 unique N-terminal TMSs and 6 TMSs that form the translocation pore with N- and C-termini in the cytosol (Schrodt et al., 2006). The TAP2 nucleotide binding site appears to be the main catalytic active site driving transport suggesting asymmetry in the transporter (Perria et al., 2006). The TAP complex shows strict coupling between peptide binding and ATP hydrolysis, revealing no basal ATPase activity in the absence of peptides from Homo sapiens (Human) (see 21 papers)
TAP2 antigen peptide transporter 2 from Homo sapiens (see paper)
32% identity, 89% coverage of query (276 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
35% identity, 85% coverage of query (272 bits)
6qv0B Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
31% identity, 83% coverage of query (268 bits)
Build an alignment for Ga0059261_3276 and 100 homologs with ≥ 30% identity
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Lawrence Berkeley National Laboratory