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Searching for up to 100 curated homologs for Ga0059261_3663 Ga0059261_3663 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (451 a.a.)

Found high-coverage hits (≥70%) to 60 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q2P7P9 UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Xanthomonas oryzae pv. oryzae (see paper)
    45% identity, 97% coverage of query (337 bits)

Q8Z9S7 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Yersinia pestis
    42% identity, 97% coverage of query (337 bits)

YieA / b3730 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase (EC 2.7.7.23; EC 2.3.1.157) from Escherichia coli K-12 substr. MG1655 (see 15 papers)
glmU / P0ACC7 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase (EC 2.7.7.23; EC 2.3.1.157) from Escherichia coli (strain K12) (see 13 papers)
GLMU_ECOLI / P0ACC7 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Escherichia coli (strain K12) (see 8 papers)
P0ACC7 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Escherichia coli (see 8 papers)
glmU / GB|AAC76753.1 bifunctional protein glmU; EC 2.3.1.157; EC 2.7.7.23 from Escherichia coli (see 10 papers)
    42% identity, 97% coverage of query (329 bits)

2oi6B / P0ACC7 E. Coli glmu- complex with udp-glcnac, coa and glcn-1-po4 (see paper)
    42% identity, 97% coverage of query (327 bits)

4fceA / Q8Z9S7 Crystal structure of yersinia pestis glmu in complex with alpha-d- glucosamine 1-phosphate (gp1)
    42% identity, 96% coverage of query (327 bits)

1hv9B Structure of e. Coli glmu: analysis of pyrophosphorylase and acetyltransferase active sites
    42% identity, 97% coverage of query (327 bits)

2oi7A E. Coli glmu- complex with udp-glcnac, desulpho-coa and glcnac-1-po4
    42% identity, 96% coverage of query (327 bits)

2oi5A E. Coli glmu- complex with udp-glcnac and acetyl-coa
    42% identity, 96% coverage of query (327 bits)

GLMU_HAEIN / P43889 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
P43889 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) from Haemophilus influenzae (see paper)
    40% identity, 98% coverage of query (325 bits)

4e1kA / P43889 Glmu in complex with a quinazoline compound (see paper)
    40% identity, 96% coverage of query (321 bits)

4kqlA Hin glmu bound to wg578
    40% identity, 96% coverage of query (321 bits)

4kpzA Hin glmu bound to a small molecule fragment
    40% identity, 96% coverage of query (321 bits)

4kpxA Hin glmu bound to wg766
    40% identity, 96% coverage of query (321 bits)

4knxA Hin glmu bound to wg176
    40% identity, 96% coverage of query (321 bits)

4knrA Hin glmu bound to wg188
    40% identity, 96% coverage of query (321 bits)

2w0wA Crystal structure of glmu from haemophilus influenzae in complex with quinazoline inhibitor 2
    40% identity, 96% coverage of query (321 bits)

2w0vA Crystal structure of glmu from haemophilus influenzae in complex with quinazoline inhibitor 1
    40% identity, 96% coverage of query (321 bits)

2vd4A Structure of small-molecule inhibitor of glmu from haemophilus influenzae reveals an allosteric binding site
    40% identity, 96% coverage of query (321 bits)

2v0lA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
    40% identity, 96% coverage of query (321 bits)

2v0kA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1- phosphate uridyltransferase (glmu)
    40% identity, 96% coverage of query (321 bits)

2v0iA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
    40% identity, 96% coverage of query (321 bits)

2v0jA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
    40% identity, 96% coverage of query (320 bits)

GLMU_STRPN / Q97R46 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see 2 papers)
    39% identity, 96% coverage of query (312 bits)

1hm8A / Q97R46 Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a (see paper)
    39% identity, 96% coverage of query (312 bits)

1hm9A Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a and udp-n- acetylglucosamine
    39% identity, 96% coverage of query (312 bits)

7kr9A Bifunctional enzyme glmu bound to zn(ii)
    39% identity, 96% coverage of query (310 bits)

1g97A S.Pneumoniae glmu complexed with udp-n-acetylglucosamine and mg2+
    39% identity, 94% coverage of query (308 bits)

4aawA S.Pneumoniae glmu in complex with an antibacterial inhibitor
    39% identity, 96% coverage of query (307 bits)

4ac3A S.Pneumoniae glmu in complex with an antibacterial inhibitor
    39% identity, 96% coverage of query (307 bits)

Q50986 UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Neisseria gonorrhoeae (see paper)
    41% identity, 97% coverage of query (306 bits)

GLMU_MYCTU / P9WMN3 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U161 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 2 papers)
P9WMN3 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 13 papers)
    38% identity, 99% coverage of query (274 bits)

3st8A Crystal structure of glmu from mycobacterium tuberculosis in complex with coenzyme a, glucosamine 1-phosphate and uridine-diphosphate-n- acetylglucosamine
    38% identity, 99% coverage of query (274 bits)

3sptA Crystal structure of glmu from mycobacterium tuberculosis in complex with acetyl coenzyme a and uridine-diphosphate-n-acetylglucosamine
    38% identity, 99% coverage of query (274 bits)

6ge9A Structure of mycobacterium tuberculosis glmu bound to glc-1p and ac- coa
    38% identity, 99% coverage of query (273 bits)

4k6rA Crystal structure of glmu in complex with atp
    38% identity, 98% coverage of query (272 bits)

3d8vA / P9WMN3 Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine (see paper)
    38% identity, 99% coverage of query (267 bits)

4g3pA Crystal structure of glmu from mycobacterium tuberculosis snapshot 3
    37% identity, 98% coverage of query (257 bits)

3dj4A Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine.
    37% identity, 98% coverage of query (257 bits)

glmU / Q9PPA2 GDP-glucosamine N-acetyltransferase from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    36% identity, 96% coverage of query (244 bits)

2qkxA N-acetyl glucosamine 1-phosphate uridyltransferase from mycobacterium tuberculosis complex with n-acetyl glucosamine 1-phosphate
    37% identity, 80% coverage of query (218 bits)

3foqA / P9WMN3 Crystal structure of n-acetylglucosamine-1-phosphate uridyltransferase (glmu) from mycobacterium tuberculosis in a cubic space group. (see paper)
    34% identity, 98% coverage of query (213 bits)

Build an alignment

Build an alignment for Ga0059261_3663 and 41 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

ST0452 / Q975F9 multifunctional glucose-1-phosphate thymidylyltransferase/hexosamine-1-phosphate N-acetyltransferase/UDP-N-acetylhexosamine diphosphorylase (EC 2.7.7.24; EC 2.7.7.23; EC 2.7.7.83; EC 2.3.1.157; EC 2.3.1.276) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see 2 papers)
S1PNA_SULTO / Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 5 papers)
Q975F9 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); galactosamine-1-phosphate N-acetyltransferase (EC 2.3.1.276); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23); glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24); aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37); UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83); UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) from Sulfurisphaera tokodaii (see 7 papers)
2ggqA / Q975F9 Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
    29% identity, 92% coverage of query (143 bits)

5z09A St0452(y97n)-utp binding form
    28% identity, 92% coverage of query (139 bits)

GLMU_METJA / Q58501 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
    25% identity, 94% coverage of query (119 bits)

GMPPB_PIG / P0C5I2 Mannose-1-phosphate guanyltransferase beta; GDP-mannose pyrophosphorylase 37-kDa subunit; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta; EC 2.7.7.13 from Sus scrofa (Pig) (see 2 papers)
    22% identity, 80% coverage of query (67.8 bits)

GMPPB_HUMAN / Q9Y5P6 Mannose-1-phosphate guanyltransferase beta; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta; EC 2.7.7.13 from Homo sapiens (Human) (see 4 papers)
Q9Y5P6 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Homo sapiens (see paper)
7d72K / Q9Y5P6 Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
    23% identity, 80% coverage of query (66.2 bits)

7d73E Cryo-em structure of gmppa/gmppb complex bound to gtp (state i)
    23% identity, 80% coverage of query (66.2 bits)

7d72E Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose
    23% identity, 80% coverage of query (66.2 bits)

GMPPB_DANRE / Q6DBU5 Mannose-1-phosphate guanyltransferase beta; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta; EC 2.7.7.13 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Q6DBU5 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Danio rerio (see paper)
    21% identity, 78% coverage of query (64.7 bits)

agl11 / D4GU70 glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL11_HALVD / D4GU70 Low-salt glycan biosynthesis nucleotidyltransferase Agl11; EC 2.7.7.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    24% identity, 87% coverage of query (62.8 bits)

Q6Z9A3 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Oryza sativa Japonica Group (see paper)
    22% identity, 75% coverage of query (55.5 bits)

Q941T9 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Oryza sativa Japonica Group (see paper)
    22% identity, 74% coverage of query (54.3 bits)

7x8kB / O22287 Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
    21% identity, 73% coverage of query (53.9 bits)

CYT1 / O22287 GDP-D-mannose pyrophosphorylase (EC 2.7.7.13) from Arabidopsis thaliana (see paper)
GMPP1_ARATH / O22287 Mannose-1-phosphate guanylyltransferase 1; GDP-mannose pyrophosphorylase 1; Protein CYTOKINESIS DEFECTIVE 1; Protein EMBRYO DEFECTIVE 101; Protein HYPERSENSITIVE TO AMMONIUM ION 1; Protein SENSITIVE TO OZONE 1; Protein VITAMIN C DEFECTIVE 1; EC 2.7.7.13 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
O22287 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Arabidopsis thaliana (see 2 papers)
    21% identity, 73% coverage of query (53.5 bits)

Q9M2S0 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Arabidopsis thaliana (see paper)
    21% identity, 73% coverage of query (53.1 bits)

GMPP_MYCTU / L7N6A5 Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; EC 2.7.7.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    25% identity, 75% coverage of query (52.0 bits)

7x8kA Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound)
    21% identity, 73% coverage of query (52.0 bits)

Q6J1L7 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13); mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) from Solanum lycopersicum (see paper)
    21% identity, 73% coverage of query (51.6 bits)

A0EJL9 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13); mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) from Malpighia glabra (see 2 papers)
    21% identity, 73% coverage of query (50.4 bits)

MPG11_CANGA / Q9Y725 Mannose-1-phosphate guanyltransferase 1; ATP-mannose-1-phosphate guanylyltransferase 1; GDP-mannose pyrophosphorylase 1; EC 2.7.7.13 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see paper)
Q9Y725 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from [Candida] glabrata (see paper)
    22% identity, 76% coverage of query (49.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory