Searching for up to 100 curated homologs for Ga0059261_3808 FitnessBrowser__Korea:Ga0059261_3808 (267 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O87725 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Acetoanaerobium sticklandii (see paper)
    32% identity, 88% coverage of query (109 bits)

proC / AAG27705.1 delta 1-pyrroline-5-carboxylate reductase from Bradyrhizobium japonicum (see paper)
    35% identity, 96% coverage of query (108 bits)

P5CR2_BACSU / P54552 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; PCA reductase 2; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
    32% identity, 98% coverage of query (107 bits)

PROC1 / F2E7Q2 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Hordeum vulgare subsp. vulgare (see paper)
    35% identity, 73% coverage of query (104 bits)

CCNA_00528 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Caulobacter crescentus NA1000
    37% identity, 96% coverage of query (103 bits)

3triA / Q83A21 Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
    33% identity, 96% coverage of query (102 bits)

2ag8A / Q9K1N1 NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
    33% identity, 96% coverage of query (101 bits)

Q97ZT3 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Saccharolobus solfataricus (see paper)
    33% identity, 75% coverage of query (97.4 bits)

P5CR_PSEAE / P22008 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    35% identity, 76% coverage of query (97.1 bits)

DVU2332 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Desulfovibrio vulgaris Hildenborough JW710
    31% identity, 97% coverage of query (96.7 bits)

Q4DH60 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Trypanosoma cruzi (see paper)
    30% identity, 84% coverage of query (94.0 bits)

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Build an alignment for Ga0059261_3808 and 11 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

P5CR1_BACSU / P0CI77 Pyrroline-5-carboxylate reductase 1; P5C reductase 1; P5CR 1; PCA reductase 1; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
    28% identity, 87% coverage of query (91.7 bits)

5uatC Structure of human pycr-1 complexed with NADPH
    31% identity, 94% coverage of query (91.7 bits)

5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid
    31% identity, 94% coverage of query (91.7 bits)

2izzA Crystal structure of human pyrroline-5-carboxylate reductase
    31% identity, 94% coverage of query (91.7 bits)

PYCR1 / P32322 pyrroline-5-carboxylate reductase 1 subunit (EC 1.5.1.2) from Homo sapiens (see 2 papers)
P5CR1_HUMAN / P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
P32322 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 7 papers)
    31% identity, 94% coverage of query (91.3 bits)

6xp1B / P32322 Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate (see paper)
    31% identity, 94% coverage of query (91.3 bits)

5uauA Structure of human pycr-1 complexed with proline
    31% identity, 94% coverage of query (91.3 bits)

6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid
    31% identity, 94% coverage of query (91.3 bits)

2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP
    31% identity, 94% coverage of query (91.3 bits)

2gr9A Crystal structure of p5cr complexed with nadh
    31% identity, 94% coverage of query (91.3 bits)

6xp2A Structure of human pycr1 complexed with l-thiazolidine-4-carboxylate
    34% identity, 73% coverage of query (89.7 bits)

P5CR1_MOUSE / Q922W5 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Mus musculus (Mouse) (see paper)
    30% identity, 94% coverage of query (89.4 bits)

6xp0A Structure of human pycr1 complexed with n-formyl l-proline
    34% identity, 73% coverage of query (89.4 bits)

P5CR_TREPA / P27771 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Treponema pallidum (strain Nichols) (see paper)
    33% identity, 86% coverage of query (89.0 bits)

CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Pedobacter sp. GW460-11-11-14-LB5
    28% identity, 88% coverage of query (89.0 bits)

P5CR2_HUMAN / Q96C36 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
Q96C36 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 2 papers)
    31% identity, 94% coverage of query (88.2 bits)

P5CR_KLULA / Q6CR99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    31% identity, 73% coverage of query (88.2 bits)

ProC / b0386 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
proC / P0A9L8 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli (strain K12) (see 8 papers)
P5CR_ECOLI / P0A9L8 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Escherichia coli (strain K12) (see 2 papers)
proC / MB|P0A9L8 pyrroline-5-carboxylate reductase from Escherichia coli K12 (see paper)
    29% identity, 95% coverage of query (85.9 bits)

DvMF_3161 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Desulfovibrio vulgaris Miyazaki F
    31% identity, 96% coverage of query (85.5 bits)

Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Shewanella loihica PV-4
    30% identity, 86% coverage of query (83.2 bits)

P5CR_METAC / Q9HH99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
    30% identity, 88% coverage of query (82.4 bits)

P5CR3_HUMAN / Q53H96 Pyrroline-5-carboxylate reductase 3; P5C reductase 3; P5CR 3; Pyrroline-5-carboxylate reductase-like protein; EC 1.5.1.2 from Homo sapiens (Human) (see paper)
    27% identity, 88% coverage of query (79.7 bits)

PRO3 / P32263 pyrroline-5-carboxylate reductase subunit (EC 1.5.1.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
P5CR_YEAST / P32263 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    28% identity, 87% coverage of query (79.3 bits)

2ahrE / Q9A1S9 Crystal structures of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
    28% identity, 96% coverage of query (79.0 bits)

2rcyA / Q8IDC6 Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
    26% identity, 75% coverage of query (78.6 bits)

2amfA Crystal structure of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes
    28% identity, 96% coverage of query (78.6 bits)

Q5NQR9 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Zymomonas mobilis subsp. mobilis (see paper)
    27% identity, 96% coverage of query (75.1 bits)

F4K884 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Arabidopsis thaliana (see paper)
    31% identity, 72% coverage of query (72.8 bits)

BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Bacteroides thetaiotaomicron VPI-5482
    23% identity, 87% coverage of query (62.8 bits)

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